NCT02887053

Brief Summary

The purpose of this study is to optimize clinical MR protocols and to validate MR acquisition parameters.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,807

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Nov 2008

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2008

Completed
7.7 years until next milestone

First Submitted

Initial submission to the registry

July 15, 2016

Completed
2 months until next milestone

First Posted

Study publicly available on registry

September 1, 2016

Completed
5.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 26, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 26, 2022

Completed
Last Updated

March 5, 2026

Status Verified

March 1, 2026

Enrollment Period

13.6 years

First QC Date

July 15, 2016

Last Update Submit

March 4, 2026

Conditions

Healthy Subjects

Keywords

MRIHealthy subjects

Outcome Measures

Primary Outcomes (1)

  • Image quality based on standard imaging quality criteria

    Image quality criteria will be : * Signal to Noise Ratio and Contrast to Noise Ratio measured in arbitrary units. * absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale

    6 months after the last inclusion

Secondary Outcomes (7)

  • T1/T2 Quantitative sub studies

    6 months after the last inclusion

  • Brain Functional MRI sub studies

    6 months after the last inclusion

  • Cardiac function MRI sub studies: volume

    6 months after the last inclusion

  • Cardiac mass MRI sub studies: mass

    6 months after the last inclusion

  • Cardiac function MRI sub studies: ejection fraction

    6 months after the last inclusion

  • +2 more secondary outcomes

Study Arms (1)

All subjects

EXPERIMENTAL

All subjects will have an MRI examination

Device: MRI

Interventions

MRIDEVICE
All subjects

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • to be over 18 year-old,
  • to be able to give an informed consent,
  • to present no contraindication to MR examination,
  • to be enrolled in a social security plan.

You may not qualify if:

  • subject refusal,
  • subject under a measure of legal protection,
  • any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHRU de Nancy

Nancy, 5400, France

Location

Related Publications (27)

  • Isaieva K, Meullenet C, Vuissoz PA, Fauvel M, Nohava L, Laistler E, Zeroual MA, Henrot P, Felblinger J, Odille F. Feasibility of online non-rigid motion correction for high-resolution supine breast MRI. Magn Reson Med. 2023 Nov;90(5):2130-2143. doi: 10.1002/mrm.29768. Epub 2023 Jun 28.

    PMID: 37379467RESULT

  • Meullenet C, Isaieva K, Odille F, Dessale C, Felblinger J, Henrot P. Evaluation of Image Quality of Motion-Corrected Supine Breast MRI. Curr Probl Diagn Radiol. 2023 Nov-Dec;52(6):493-500. doi: 10.1067/j.cpradiol.2023.05.013. Epub 2023 May 11.

    PMID: 37258350RESULT

  • Isaieva K, Leclere J, Felblinger J, Gillet R, Dubernard X, Vuissoz PA. Methodology for quantitative evaluation of mandibular condyles motion symmetricity from real-time MRI in the axial plane. Magn Reson Imaging. 2023 Oct;102:115-125. doi: 10.1016/j.mri.2023.05.006. Epub 2023 May 13.

    PMID: 37187265RESULT

  • Douros IK, Xie Y, Dourou C, Isaieva K, Vuissoz PA, Felblinger J, Laprie Y. 3D Dynamic Spatiotemporal Atlas of the Vocal Tract during Consonant-Vowel Production from 2D Real Time MRI. J Imaging. 2022 Aug 25;8(9):227. doi: 10.3390/jimaging8090227.

    PMID: 36135393RESULT

  • Isaieva K, Fauvel M, Weber N, Vuissoz PA, Felblinger J, Oster J, Odille F. A hardware and software system for MRI applications requiring external device data. Magn Reson Med. 2022 Sep;88(3):1406-1418. doi: 10.1002/mrm.29280. Epub 2022 May 4.

    PMID: 35506503RESULT

  • Draveny R, Ambarki K, Han F, Hilbert T, Laurent V, Morel O, Bertholdt C, Beaumont M. Comparison of T2 Quantification Strategies in the Abdominal-Pelvic Region for Clinical Use. Invest Radiol. 2022 Jun 1;57(6):412-421. doi: 10.1097/RLI.0000000000000852. Epub 2022 Jan 10.

    PMID: 34999669RESULT

  • Le Bars AL, Moulin K, Ennis DB, Felblinger J, Chen B, Odille F. In Vivo Super-Resolution Cardiac Diffusion Tensor MRI: A Feasibility Study. Diagnostics (Basel). 2022 Mar 31;12(4):877. doi: 10.3390/diagnostics12040877.

    PMID: 35453925RESULT

  • Isaieva K, Laprie Y, Leclere J, Douros IK, Felblinger J, Vuissoz PA. Multimodal dataset of real-time 2D and static 3D MRI of healthy French speakers. Sci Data. 2021 Oct 1;8(1):258. doi: 10.1038/s41597-021-01041-3.

    PMID: 34599194RESULT

  • Soullie P, Missoffe A, Ambarki K, Felblinger J, Odille F. MR electrical properties imaging using a generalized image-based method. Magn Reson Med. 2021 Feb;85(2):762-776. doi: 10.1002/mrm.28458. Epub 2020 Aug 11.

    PMID: 32783236RESULT

  • Isaieva K, Laprie Y, Odille F, Douros IK, Felblinger J, Vuissoz PA. Measurement of Tongue Tip Velocity from Real-Time MRI and Phase-Contrast Cine-MRI in Consonant Production. J Imaging. 2020 May 13;6(5):31. doi: 10.3390/jimaging6050031.

    PMID: 34460733RESULT

  • Dos Reis JE, Odille F, Petitmangin G, Guillou A, Vuissoz PA, Felblinger J, Oster J. Broadband electrocardiogram acquisition for improved suppression of MRI gradient artifacts. Physiol Meas. 2020 May 7;41(4):045004. doi: 10.1088/1361-6579/ab7b8e.

    PMID: 32120353RESULT

  • Dos Reis JE, Soullie P, Oster J, Palmero Soler E, Petitmangin G, Felblinger J, Odille F. Reconstruction of the 12-lead ECG using a novel MR-compatible ECG sensor network. Magn Reson Med. 2019 Nov;82(5):1929-1945. doi: 10.1002/mrm.27854. Epub 2019 Jun 14.

    PMID: 31199011RESULT

  • Delbany M, Bustin A, Poujol J, Thomassin-Naggara I, Felblinger J, Vuissoz PA, Odille F. One-millimeter isotropic breast diffusion-weighted imaging: Evaluation of a superresolution strategy in terms of signal-to-noise ratio, sharpness and apparent diffusion coefficient. Magn Reson Med. 2019 Apr;81(4):2588-2599. doi: 10.1002/mrm.27591. Epub 2018 Dec 10.

    PMID: 30536764RESULT

  • Bustin A, Voilliot D, Menini A, Felblinger J, de Chillou C, Burschka D, Bonnemains L, Odille F. Isotropic Reconstruction of MR Images Using 3D Patch-Based Self-Similarity Learning. IEEE Trans Med Imaging. 2018 Aug;37(8):1932-1942. doi: 10.1109/TMI.2018.2807451. Epub 2018 Feb 19.

    PMID: 29994581RESULT

  • Dupont AC, Poussel M, Hossu G, Marie PY, Chenuel B, Felblinger J, Mandry D. Aortic compliance variation in long male distance triathletes: A new insight into the athlete's artery? J Sci Med Sport. 2017 Jun;20(6):539-542. doi: 10.1016/j.jsams.2016.10.009. Epub 2016 Oct 29.

    PMID: 27838232RESULT

  • Fayad H, Odille F, Schmidt H, Wurslin C, Kustner T, Feblinger J, Visvikis D. The use of a generalized reconstruction by inversion of coupled systems (GRICS) approach for generic respiratory motion correction in PET/MR imaging. Phys Med Biol. 2015 Mar 21;60(6):2529-46. doi: 10.1088/0031-9155/60/6/2529. Epub 2015 Mar 6.

    PMID: 25746098RESULT

  • Menini A, Slavin GS, Stainsby JA, Ferry P, Felblinger J, Odille F. Motion correction of multi-contrast images applied to T(1)and T(2)quantification in cardiac MRI. MAGMA. 2015 Feb;28(1):1-12. doi: 10.1007/s10334-014-0440-9.

    PMID: 24659257RESULT

  • Meyer C, Bonnemains L, Marcon F, Marie PY, Felblinger J, Vuissoz PA. Longitudinal myocardial peak velocities using high temporal resolution phase-contrast and simple averaging are comparable to tissue Doppler echocardiography. MAGMA. 2014 Jun;27(3):211-8. doi: 10.1007/s10334-013-0405-4. Epub 2013 Sep 8.

    PMID: 24013857RESULT

  • de Roquefeuil M, Vuissoz PA, Escanye JM, Felblinger J. Effect of physiological heart rate variability on quantitative T2 measurement with ECG-gated Fast Spin Echo (FSE) sequence and its retrospective correction. Magn Reson Imaging. 2013 Nov;31(9):1559-66. doi: 10.1016/j.mri.2013.06.006. Epub 2013 Aug 15.

    PMID: 23954080RESULT

  • Clique H, Cheng HL, Marie PY, Felblinger J, Beaumont M. 3D myocardial T1 mapping at 3T using variable flip angle method: pilot study. Magn Reson Med. 2014 Feb;71(2):823-9. doi: 10.1002/mrm.24688.

    PMID: 23440632RESULT

  • Menini A, Vuissoz PA, Felblinger J, Odille F. Joint reconstruction of image and motion in MRI: implicit regularization using an adaptive 3D mesh. Med Image Comput Comput Assist Interv. 2012;15(Pt 1):264-71. doi: 10.1007/978-3-642-33415-3_33.

    PMID: 23285560RESULT

  • Vuissoz PA, Odille F, Fernandez B, Lohezic M, Benhadid A, Mandry D, Felblinger J. Free-breathing imaging of the heart using 2D cine-GRICS (generalized reconstruction by inversion of coupled systems) with assessment of ventricular volumes and function. J Magn Reson Imaging. 2012 Feb;35(2):340-51. doi: 10.1002/jmri.22818. Epub 2011 Oct 11.

    PMID: 21990103RESULT

  • Labrousse M, Hossu G, Calmon G, Chays A, Felblinger J, Braun M. In vivo characterization of the vestibulo-cochlear nerve motion by MRI. Neuroimage. 2012 Jan 16;59(2):943-9. doi: 10.1016/j.neuroimage.2011.08.058. Epub 2011 Sep 5.

    PMID: 21924360RESULT

  • Fernandez B, Oster J, Lohezic M, Mandry D, Pietquin O, Vuissoz PA, Felblinger J. Adaptive black blood fast spin echo for end-systolic rest cardiac imaging. Magn Reson Med. 2010 Dec;64(6):1760-71. doi: 10.1002/mrm.22566. Epub 2010 Jul 30.

    PMID: 20677228RESULT

  • Cindea N, Odille F, Bosser G, Felblinger J, Vuissoz PA. Reconstruction from free-breathing cardiac MRI data using reproducing kernel Hilbert spaces. Magn Reson Med. 2010 Jan;63(1):59-67. doi: 10.1002/mrm.22170.

    PMID: 20027598RESULT

  • Hossu G, Fantin L, Charroud C, Felblinger J, Jacquot M, Ceyte H. Neural mechanisms of odour imagery induced by non-figurative visual cues. Neuropsychologia. 2024 Apr 15;196:108836. doi: 10.1016/j.neuropsychologia.2024.108836. Epub 2024 Feb 17.

    PMID: 38373518RESULT

  • Leclere J, Isaieva K, Drouot G, Gillet R, Felblinger J, Vuissoz PA, Dubernard X. Quantifying symmetry in mandibular condyle motion: a real-time MRI approach. J Oral Facial Pain Headache. 2025 Dec;39(4):227-234. doi: 10.22514/jofph.2025.079. Epub 2025 Dec 12.

    PMID: 41436119DERIVED

Study Officials

  • Valérie Laurent, MD,PhD

    CHRU de Nancy

    PRINCIPAL INVESTIGATOR

  • Jacques Felblinger, MD,PhD

    CHRU de Nancy

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

July 15, 2016

First Posted

September 1, 2016

Study Start

November 1, 2008

Primary Completion

May 26, 2022

Study Completion

May 26, 2022

Last Updated

March 5, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations

FR(1)