IVF Outcome After Bariatric Surgery

NCT02884258 | Completed

• 1 other identifier: IVF after Bariatric surgery
• Study Type: observational
• Target: 249
• Locations: 1 country
• Sites: 1

Brief Summary

This case-control study compares IVF results and live birth rates in women undergoing IVF with a history of bariatric surgery as compared to 2 age-matched control groups composed of (A) non-operated women matched on cases' post-operative BMI (controls 1) and (B) non-operated severely obese women (controls 2).

Conditions

Infertility; Obesity

Keywords

Assisted Reproductive Technology; Obesity; Bariatric Surgery; Infertility; Fertility Preservation

Outcome Measures

Primary Outcomes (1)

• Live birth rates

  number of live births divided by the number of embryo transfers

  nine months after embryo transfer

Secondary Outcomes (1)

• average number of mature oocytes obtained

  The day of oocyte retrieval in the case of IVF with sperm injection (ICSI) just after decoronisation, or on day one after oocyte retrieval in classical IVF. Oocyte retrieval occurs 36 hours after hCG injection after an ovarian stimulation protocol.

Study Arms (2)

Bariatric surgery group

Women undergoing IVF (IVF or ICSI) with a history of bariatric surgery (surgery procedures include sleeve gastrectomies and by-passes). No intervention is involved.

Control Group

1\. Women undergoing IVF with no history of bariatric surgery and matched to bariatric surgery patients for weight, parity and age. 2. non-operated severely obese women

Eligibility Criteria

• Age: 18 Years - 43 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women underoing IVF and having undergone bariatric surgery

You may qualify if:

• Undergoing IVF and with a history of bariatric surgery

Sponsors & Collaborators

• Clinique Mathilde: lead

Study Sites (1)

Clinique Mathilde

Rouen, 76100, France

Location

Related Publications (1)

• Grzegorczyk-Martin V, Freour T, De Bantel Finet A, Bonnet E, Merzouk M, Roset J, Roger V, Cedrin-Durnerin I, Wainer R, Avril C, Landais P. IVF outcomes in patients with a history of bariatric surgery: a multicenter retrospective cohort study. Hum Reprod. 2020 Dec 1;35(12):2755-2762. doi: 10.1093/humrep/deaa208.

  PMID: 33083823 DERIVED

MeSH Terms

Conditions

Infertility; Obesity

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 26, 2016
• First Posted: August 30, 2016
• Study Start: January 1, 2012
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: November 18, 2019

Record last verified: 2019-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)