Cognitive and Emotional Factors in Visual Exploration Among Patients With Schizophrenia

NCT02874482 | Completed

• 2 other identifiers: 2013_19.12013-A01497-38
• Study Type: observational
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Patients with schizophrenia are abnormally disturbed by information onsets, which may result in a disadvantage in filtering relevant information. It seems that they accord the same importance to all objects in a scene without taking into account the relevance of objects (cognitive salience) or their emotional charge (salience emotional). The paradigm of change blindness offers the interesting possibility of studying sensitivity to the sudden irruption of visual information with ecological stimuli in schizophrenia. An increased attentional capture by the irruption of visual information would suggest better performance in patients than in healthy controls. Moreover, patients are disturbed to processing of emotional information, in this way we would like to measure the impact of emotional salience on the visual exploration. Main aim: The main objective is to evaluate, if patients with schizophrenia quickly detect changes occurring on irrelevant objects in the understanding of the scene. Secondary objectives: To evaluate in patients with schizophrenia the impact of emotional salience using the same paradigm. To separate an explicit response (motors responses) with an implicit response (eye tracking measures). Methodology: 30 patients with schizophrenia and 30 healthy controls were asked to detect changes in 96 scenes with 0 or 1 change (neutral or emotional changes). We will measure the participants' speed and accuracy in explicitly reporting the changes via motor responses and their capacity to implicitly detect changes via eye movements.

Conditions

Schizophrenia

Keywords

Schizophrenia; Change blindness; Eye tracking; Implicit response

Outcome Measures

Primary Outcomes (1)

• response time

  The explicit response of the participants will be measure behaviourally by response time before the detection of neutral stimuli.

  42 months

Secondary Outcomes (3)

• sensitivity index

  42 months

• implicit response

  42 months

• emotional response

  42 months

Study Arms (2)

Patients with schizophrenia

30 patients with schizophrenia (diagnosis based on the standard DSM criteria)

Controls

30 healthy controls without any psychiatric or neurological diagnosis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

30 patients with schizophrenia and 30 healthy controls

You may qualify if:

• Normal or corrected vision
• Affiliate to a social security system
• For group of patients with schizophrenia : diagnosis of schizophrenia based on the standard DSM-IV criteria and patients will be clinically stable at the testing time

You may not qualify if:

• History of neurological illness
• Pregnant and nursing women
• Drugs use in the last 24 hours
• Acute ocular disorder
• Under tutorship, curatorship or deprived of liberty
• For controls group : be free DSM-IV axis-I diagnoses according the MINI test.

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

University Hospital, Lille

Lille, 59037, France

Location

MeSH Terms

Conditions

Schizophrenia

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Guillaume VAIVA

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 17, 2016
• First Posted: August 22, 2016
• Study Start: July 1, 2014
• Primary Completion: November 17, 2019
• Study Completion: November 17, 2019
• Last Updated: August 26, 2020

Record last verified: 2020-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)