Anti-thymocyte Globulin-induced Immune Senescence

NCT02857907 | Completed

• 1 other identifier: API/2010/15
• Study Type: observational
• Target: 97
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the study is to investigate the impact of Anti-Thymocyte Globulin (ATG) on immune senescence. Markers of immune senescence expression is assessed in a prospective cohort of renal transplant recipients the day of transplantation and one year after renal transplantation.

Conditions

Disorder Related to Renal Transplantation

Keywords

Kidney transplantation; Immunosuppressive treatment

Outcome Measures

Primary Outcomes (1)

• Percentage of senescent lymphocytes

  Flow cytometry analysis (7 colors) of lymphocytes

  One year after kidney transplantation

Study Arms (2)

ATG group

Patients who received T cell depleting ATG therapy (blood sample one year after transplantation)

Other: Blood sample

anti-CD25 group

Patients who received nondepleting anti-CD25 (blood sample one year after transplantation)

Other: Blood sample

Interventions

Blood sample OTHER

A blood sample is performed one year after kidney transplantation.

ATG group; anti-CD25 group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients awaiting kidney transplantation, followed at Besançon University Hospital and who have given their consent for the conservation of cells for a study of the immune system in kidney transplant patients.

You may qualify if:

• Patient able to understand the reason of the study
• Signature of informed consent
• Patient who are waiting renal transplant

You may not qualify if:

• Inability to understand the reasons for the study; psychiatric disorders
• Any history in the last 2 years of immunosuppressive therapy (except steroids)
• History of cancer (except skin cancer) or treated hematological malignancy

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Besancon: lead

Study Sites (1)

University Hospital

Besançon, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Peripheral Blood Mononuclear Cells

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Jamal Bamoulid, Doctor

  CHU Besançon

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 3, 2016
• First Posted: August 5, 2016
• Study Start: April 1, 2010
• Primary Completion: January 1, 2013
• Study Completion: January 1, 2013
• Last Updated: August 5, 2016

Record last verified: 2016-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)