NCT02849652

Brief Summary

Despite an overall reduction in US smoking rates from \>50% in the 1960s to about 20% by 2000, the rate of smoking among persons with a serious mental illness (SMI) remains 2-3 times greater than in the general population. Further, even the recent small decline in smoking rates that has been reported in the general population in the past decade has not occurred among smokers with an SMI. In fact, 44% of all the cigarettes consumed in the US are by individuals with a psychiatric disorder and the primary cause of death among Americans with an SMI is a tobacco-related disease. This cluster randomized trial will be conducted in 14 Philadelphia community mental health clinics (CMHCs). Clinics will be randomized to either Addressing Tobacco Through Organizational Change model (ATTOC) or Usual Care (UC) treatment groups. The investigators hypothesize that 1) at the end of the intervention and at a 3-month follow-up, rates of adherence to guidelines for treating TUD will be greater among clinic personnel that receive the ATTOC intervention vs. clinic personnel in usual care; 2) at the end of the intervention and at a 3-month follow-up, rates of client smoking cessation will be significantly greater in clinics that receive the ATTOC intervention than among clients treated with usual care; and 3) using non-inferiority testing, at the end of the intervention and at a 3-month follow-up, there will be no significant degradation in mental health functioning or QOL among clients who receive care at clinics that received the ATTOC intervention than among clients treated with usual care.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
832

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jul 2016

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2016

Completed
13 days until next milestone

First Submitted

Initial submission to the registry

July 14, 2016

Completed
15 days until next milestone

First Posted

Study publicly available on registry

July 29, 2016

Completed
6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2022

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2022

Completed
3 months until next milestone

Results Posted

Study results publicly available

February 21, 2023

Completed
Last Updated

February 21, 2023

Status Verified

February 1, 2023

Enrollment Period

6.1 years

First QC Date

July 14, 2016

Results QC Date

December 13, 2022

Last Update Submit

February 16, 2023

Conditions

Keywords

Smoking cessationNicotine dependenceOrganizational changeMental Healthcare

Outcome Measures

Primary Outcomes (2)

  • Client Reported Tobacco Medications

    Client-reported use of tobacco treatment for nicotine dependence measured via self-report

    Week 36 & Week 52

  • Rate of Medication to Treat Nicotine Dependence - EHR

    Frequency of provision of medications for nicotine dependence measured via electronic health record (EHR) data for clients.

    Week 36 & Week 52

Secondary Outcomes (4)

  • Smoking Cessation Rate

    Week 36 & Week 52

  • Mental Health Functioning

    Week 36 & Week 52

  • Short-Form Health Survey Emotional

    Week 36 & Week 52

  • Short-Form Health Survey Physical

    Week 36 and Week 52

Other Outcomes (5)

  • S-KAP: Staff-Reported Tobacco Treatment Treatment

    Week 36 and Week 52

  • S-KAP: Staff-Reported Barriers to Treat Tobacco

    Week 36 and Week 52

  • S-KAS: Client Reported Tobacco Treatment Treatment From Staff

    Week 36 and Week 52

  • +2 more other outcomes

Study Arms (2)

ATTOC

EXPERIMENTAL

Addressing Tobacco Through Organizational Change is a multi-phase organizational intervention to promote the treatment of tobacco dependence

Behavioral: ATTOC Intervention

Usual Care

OTHER

Usual Care is the typical guideline based smoking cessation intervention

Behavioral: UC Intervention

Interventions

ATTOC is implemented in a systematic 3-phase process with 10 steps to guide sites through cultural change and implementation of evidence-based practice.

ATTOC
UC InterventionBEHAVIORAL

Sites randomized to UC will not receive an organizational intervention to address TUD treatment. To ensure standardization across UC sites, study personnel will provide a 1-day training seminar that will include written materials describing recommended treatments for TUD to UC personnel consistent with established treatment guidelines.

Usual Care

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Must be a client at a participating community mental health clinic
  • Must be 18 years of age or older
  • Must report daily average smoking of 5 cigarettes/day for the past 6 months
  • Must have a documented Diagnostic and Statistical Manual Axis I or II disorder
  • Must demonstrate the ability to communicate in English and provide written informed consent

You may not qualify if:

  • Must be 18 years of age or older
  • Must perform clinical care or supervisory duties
  • Must demonstrate the ability to communicate in English and provide written informed consent
  • no clinical responsibilities

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

MeSH Terms

Conditions

Tobacco Use DisorderSmoking Cessation

Condition Hierarchy (Ancestors)

Substance-Related DisordersChemically-Induced DisordersMental DisordersHealth BehaviorBehavior

Results Point of Contact

Title
Dr. Robert Schnoll
Organization
University of Pennsylvania

Study Officials

  • Robert Schnoll, PhD

    University of Pennsylvania

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 14, 2016

First Posted

July 29, 2016

Study Start

July 1, 2016

Primary Completion

August 1, 2022

Study Completion

December 1, 2022

Last Updated

February 21, 2023

Results First Posted

February 21, 2023

Record last verified: 2023-02

Data Sharing

IPD Sharing
Will share

Once the final analyses are conducted to address the specific aims of this project, study data will be made available to other qualified researchers. The investigators plan to create a mechanism to allow such researchers to apply for access to these data.

Shared Documents
STUDY PROTOCOL, ICF
Time Frame
Final analyses will be conducted after all participant activities have been completed, approximately 9/2021. Once the final analyses are conducted to address the specific aims of this project, study data will be made available.
Access Criteria
Study data will be made available to other qualified researchers. The investigators plan to create a mechanism to allow such researchers to apply for access to these data.

Locations