NCT02843932

Brief Summary

The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder. The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin. Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
14

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started May 2015

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 12, 2015

Completed
1 day until next milestone

Study Start

First participant enrolled

May 13, 2015

Completed
1.2 years until next milestone

First Posted

Study publicly available on registry

July 26, 2016

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2019

Completed
Last Updated

November 18, 2020

Status Verified

November 1, 2020

Enrollment Period

4.1 years

First QC Date

May 12, 2015

Last Update Submit

November 16, 2020

Conditions

Somatoform Disorders

Keywords

SomatoformPsychogenic

Outcome Measures

Primary Outcomes (2)

  • Familiarization with the joystick.

    HHSC-JOY-I from Current Designs. They are asked to trace a straight line.

    30 minutes

  • Brain MRI

    One hour and a half

Study Arms (1)

Psychogenic disorders

EXPERIMENTAL

Psychogenic movement disorders and seizures

Other: functional brain MRI

Interventions

functional brain MRIOTHER

functional imagery during motor-perception tasks

Psychogenic disorders

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Signed informed consent
  • Medical exam médical done before study participation
  • Between 18 and 65 years
  • Right-handed persons
  • Conversion disorder based on DSM IV-R criterias
  • Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)

You may not qualify if:

  • Subjects included in a clinical and/or therapeutic exeprimentation in progress
  • People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia
  • Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale
  • History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.
  • Alcohol ingestion
  • Pregnant, parturient or breastfeeding women
  • All other categories of protected persons

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Chu Grenoble

Grenoble, 38043, France

Location

Related Publications (17)

  • Desmurget M, Grafton S. Forward modeling allows feedback control for fast reaching movements. Trends Cogn Sci. 2000 Nov 1;4(11):423-431. doi: 10.1016/s1364-6613(00)01537-0.

    PMID: 11058820BACKGROUND

  • Wolpert DM, Ghahramani Z, Jordan MI. An internal model for sensorimotor integration. Science. 1995 Sep 29;269(5232):1880-2. doi: 10.1126/science.7569931.

    PMID: 7569931BACKGROUND

  • Sabes PN. The planning and control of reaching movements. Curr Opin Neurobiol. 2000 Dec;10(6):740-6. doi: 10.1016/s0959-4388(00)00149-5.

    PMID: 11240283BACKGROUND

  • Rothwell JC, Traub MM, Day BL, Obeso JA, Thomas PK, Marsden CD. Manual motor performance in a deafferented man. Brain. 1982 Sep;105 (Pt 3):515-42. doi: 10.1093/brain/105.3.515.

    PMID: 6286035BACKGROUND

  • Ghez C, Hening W, Gordon J. Organization of voluntary movement. Curr Opin Neurobiol. 1991 Dec;1(4):664-71. doi: 10.1016/s0959-4388(05)80046-7.

    PMID: 1822314BACKGROUND

  • van Beers RJ, Baraduc P, Wolpert DM. Role of uncertainty in sensorimotor control. Philos Trans R Soc Lond B Biol Sci. 2002 Aug 29;357(1424):1137-45. doi: 10.1098/rstb.2002.1101.

    PMID: 12217180BACKGROUND

  • Fourneret P, Jeannerod M. Limited conscious monitoring of motor performance in normal subjects. Neuropsychologia. 1998 Nov;36(11):1133-40. doi: 10.1016/s0028-3932(98)00006-2.

    PMID: 9842759BACKGROUND

  • Carson AJ, Stone J, Warlow C, Sharpe M. Patients whom neurologists find difficult to help. J Neurol Neurosurg Psychiatry. 2004 Dec;75(12):1776-8. doi: 10.1136/jnnp.2003.032169.

    PMID: 15548505BACKGROUND

  • Vuilleumier P, Chicherio C, Assal F, Schwartz S, Slosman D, Landis T. Functional neuroanatomical correlates of hysterical sensorimotor loss. Brain. 2001 Jun;124(Pt 6):1077-90. doi: 10.1093/brain/124.6.1077.

    PMID: 11353724BACKGROUND

  • Cojan Y, Waber L, Carruzzo A, Vuilleumier P. Motor inhibition in hysterical conversion paralysis. Neuroimage. 2009 Sep;47(3):1026-37. doi: 10.1016/j.neuroimage.2009.05.023. Epub 2009 May 18.

    PMID: 19450695BACKGROUND

  • Cojan Y, Vuilleumier P. Functional brain imaging of psychogenic paralysis during conversion and hypnosis

    BACKGROUND

  • Hallet M, cloninger CR, Fahn S, Halligan P, Jankovic J, Lang AE, Voon V Psychogenic movement disorders and other conversion disorders. Cambridge University Press 2011

    BACKGROUND

  • de Lange FP, Roelofs K, Toni I. Motor imagery: a window into the mechanisms and alterations of the motor system. Cortex. 2008 May;44(5):494-506. doi: 10.1016/j.cortex.2007.09.002. Epub 2007 Dec 23.

    PMID: 18387583BACKGROUND

  • Blakemore SJ, Wolpert DM, Frith CD. Abnormalities in the awareness of action. Trends Cogn Sci. 2002 Jun 1;6(6):237-242. doi: 10.1016/s1364-6613(02)01907-1.

    PMID: 12039604BACKGROUND

  • de Lange FP, Roelofs K, Toni I. Increased self-monitoring during imagined movements in conversion paralysis. Neuropsychologia. 2007 May 15;45(9):2051-8. doi: 10.1016/j.neuropsychologia.2007.02.002. Epub 2007 Feb 11.

    PMID: 17367826BACKGROUND

  • Friston KJ, Holmes AP, Worsley KJ. How many subjects constitute a study? Neuroimage. 1999 Jul;10(1):1-5. doi: 10.1006/nimg.1999.0439.

    PMID: 10385576BACKGROUND

  • Stone J, Carson A, Sharpe M. Functional symptoms in neurology: management. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1(Suppl 1):i13-21. doi: 10.1136/jnnp.2004.061663. No abstract available.

    PMID: 15718216BACKGROUND

MeSH Terms

Conditions

Somatoform Disorders

Condition Hierarchy (Ancestors)

Mental Disorders

Study Officials

  • Tiphaine Montagnon

    DRCI, CHU GRENOBLE, FRANCE

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 12, 2015

First Posted

July 26, 2016

Study Start

May 13, 2015

Primary Completion

June 1, 2019

Study Completion

June 1, 2019

Last Updated

November 18, 2020

Record last verified: 2020-11

Locations

FR(1)