Cerebral Substrates of Prospective Memory in Young and Its Disruption in Normal Aging and in Alzheimer's Disease: A Study in Anatomical MRI, Diffusion Tensor MRI and Functional MRI

NCT02522091 | Unknown

• 1 other identifier: 10-002
• Study Type: interventional
• Target: 178
• Locations: 1 country
• Sites: 1

Brief Summary

Investigators propose in this study to evaluate prospective memory (MP) in all its complexity as well as the processes, cognitive and brain, the underlying. Specifically, investigators propose to evaluate the evolution of the MP during normal aging and Alzheimer's disease (AD) to identify the cognitive and brain processes underlying this development. To do this, this study will have to include healthy subjects, 18 to 95 years, patients with Mild Cognitive Impairment (MCI) and patients with probable AD. All participants will undergo a series of examinations, both neuropsychological and brain imaging.

Conditions

Alzheimer's Disease

Outcome Measures

Primary Outcomes (1)

• measuring the amplitude of the BOLD signal (Blood Oxygen Level Dependent)

  baseline

Study Arms (5)

young healthy volunteers (18-44 years old)

OTHER

young healthy volunteers (18-44 years old)

Device: functional brain MRI; Other: Neuropsychology tests

healthy volunteers (45-69 years old)

OTHER

healthy volunteers (45-69 years old)

Device: functional brain MRI; Other: Neuropsychology tests

Mild Cognitive Impairment Patients

OTHER

Mild Cognitive Impairment Patients

Device: functional brain MRI; Other: Neuropsychology tests

Alzheimer's Disease patient

OTHER

Alzheimer's Disease patient

Device: functional brain MRI; Other: Neuropsychology tests

old healthy volunteers (70+ years old)

OTHER

old healthy volunteers (70+ years old)

Device: functional brain MRI; Other: Neuropsychology tests

Interventions

functional brain MRI DEVICE

Alzheimer's Disease patient; Mild Cognitive Impairment Patients; healthy volunteers (45-69 years old); old healthy volunteers (70+ years old); young healthy volunteers (18-44 years old)

Neuropsychology tests OTHER

Alzheimer's Disease patient; Mild Cognitive Impairment Patients; healthy volunteers (45-69 years old); old healthy volunteers (70+ years old); young healthy volunteers (18-44 years old)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All participants:
• Normal Education\> 7 years
• French mother tongue
• right-handed (Edinburgh Inventory)
• score on the scale of Beck \<7 (depression scale)
• signing the informed consent of the protocol in agreement with the Committee to Protect People

You may not qualify if:

• Young healthy subjects aged between 18 and 44 years
• Healthy subjects intermediate age: between 45 and 69 years
• score on the Mattis Dementia Scale higher than 137, in order to exclude any potential dementia
• Performance "normal" to test RI RL-16 (that is to say, not differing by more than 1.65 standard deviation from the norm for age and cultural level \[see normative values published Van der Linden et al., 2004\]), test conventionally used to assess the verbal episodic memory.
• Healthy elderly subjects aged 70 and over, living at home
• score on the Mattis Dementia Scale higher than 137, in order to exclude any potential dementia
• Performance "normal" to test RI RL-16 (that is to say, not differing by more than 1.65 standard deviation from the norm for age and cultural level \[see normative values published Van der Linden et al., 2004\]), test conventionally used to assess the verbal episodic memory.
• MCI patients: older than 50 years and recruited from memory clinics and meet the current criteria and recognized including amnestic MCI
• memory complaint
• targets deficits of episodic memory (lower performance of at least 1 standard deviation from the norm for age and cultural level to one or more (sub) episodic memory scores of diagnostic battery - cf. . Tables 1 and infra)
• performance in the standards for age and cultural level in all tests of diagnostic battery measuring other cognitive functions as memory, including the evaluation of overall cognitive ability tests.
• Alzheimer's patients: older than 50 years were recruited from the clinics and memory satisfying the standards NINCDS-ADRDA criteria for probable AD which include
• abnormal global cognitive functioning and deficits in two or more cognitive domains identified by the diagnostic battery
• mild to moderate AD (MMSE ≥ 18).
• Cognitive disorders of sudden onset (contrary to their slow and progressive onset in AD), which could reflect a stroke; a modified Hachinski ischemic score ≤ 2 (Loeb \& Gandolfo, 1983); history of head trauma with loss of consciousness for more than 1 hour, or encephalitis;

Sponsors & Collaborators

• University Hospital, Caen: lead

Study Sites (1)

Service de neurologie

Caen, CHU, 14000, France

RECRUITING

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 5, 2015
• First Posted: August 13, 2015
• Study Start: November 1, 2010
• Primary Completion: December 1, 2015
• Last Updated: August 13, 2015

Record last verified: 2015-08

Locations

FR (1)