Cognitive Vulnerability Factors in Alcohol-dependence
CoVAD
Study of Mental Flexibility and Inhibition Processes as Cognitive Vulnerability Markers of Alcohol Dependence
1 other identifier
interventional
261
1 country
1
Brief Summary
The purpose of this study is to specify the cognitive and genetic pattern associated with alcohol dependence. Results will help identifying more precisely vulnerability factors associated with this disorder.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2007
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2009
CompletedFirst Submitted
Initial submission to the registry
June 27, 2016
CompletedFirst Posted
Study publicly available on registry
July 25, 2016
CompletedJuly 25, 2016
July 1, 2016
1.5 years
June 27, 2016
July 20, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
questionnaire
comparison of questionnaires score for the 3 groups
Day 0
Secondary Outcomes (1)
genetic polymorphism
Day 0
Study Arms (3)
Alcohol-dependent patients
EXPERIMENTALFirst-degree relatives of alcohol-dependent probands
ACTIVE COMPARATORHealthy Controls
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Alcohol-dependent patients :
- Males or females, aged 18-65 years, with a diagnosis of alcohol dependence, according to the DSM-IV criteria
- Patients withdrawn from alcohol at least 2 weeks
- Native French speaker, able to read French and complete study evaluations
- Caucasian
- Able to provide informed written and verbal consent
- First-degree relatives of alcohol-dependent probands :
- Males or females, aged 18-65 years
- Caucasian
- Native French speaker, able to read French and complete study evaluations
- Able to provide informed written and verbal consent
- Healthy Controls :
- Males or females, aged 18-65 years
- Caucasian
- Native French speaker, able to read French and complete study evaluations
- +1 more criteria
You may not qualify if:
- Alcohol-dependent patients
- DSM-IV substance use disorder other than alcohol
- Severe chronic psychiatric disorders including Bipolar disorder and schizophrenia
- Mood episode diagnostic according to the DSM-IV criteria in the last six months
- A significant general medical illness, including neurological disorders
- A sensorial impairment uncorrected (visual and/or hearing)
- Individuals who are not covered by national health insurance
- First-degree relatives of alcohol-dependent probands :
- Past or recent alcohol and/or drug abuse or dependence
- Severe chronic psychiatric disorders including Bipolar disorder and schizophrenia
- Mood episode diagnostic according to the DSM-IV criteria in the last six months
- A significant general medical illness, including neurological disorders
- Handling of psychotropics substances
- A sensorial impairment uncorrected (visual and/or hearing)
- Individuals who are not covered by national health insurance
- +10 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- CHU de Reimslead
Study Sites (1)
Chu de Reims
Reims, France, 51092, France
Related Publications (4)
Gierski F, Hubsch B, Stefaniak N, Benzerouk F, Cuervo-Lombard C, Bera-Potelle C, Cohen R, Kahn JP, Limosin F. Executive functions in adult offspring of alcohol-dependent probands: toward a cognitive endophenotype? Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E356-63. doi: 10.1111/j.1530-0277.2012.01903.x. Epub 2012 Dec 14.
PMID: 23240659BACKGROUNDBenzerouk F, Gierski F, Gorwood P, Ramoz N, Stefaniak N, Hubsch B, Kaladjian A, Limosin F. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and its implication in executive functions in adult offspring of alcohol-dependent probands. Alcohol. 2013 Jun;47(4):271-4. doi: 10.1016/j.alcohol.2013.03.001. Epub 2013 Apr 10.
PMID: 23582695BACKGROUNDRaucher-Chene D, Gierski F, Hubsch B, Cuervo-Lombard CV, Bera-Potelle C, Cohen R, Kahn JP, Kaladjian A, Limosin F. Depression, anxiety and personality dimensions in female first-degree relatives of alcohol-dependent probands. Arch Womens Ment Health. 2012 Jun;15(3):229-32. doi: 10.1007/s00737-012-0271-5. Epub 2012 Mar 13.
PMID: 22411191BACKGROUNDBenzerouk F, Gierski F, Raucher-Chene D, Ramoz N, Gorwood P, Kaladjian A, Limosin F. Association study between reward dependence and a functional BDNF polymorphism in adult women offspring of alcohol-dependent probands. Psychiatr Genet. 2015 Oct;25(5):208-11. doi: 10.1097/YPG.0000000000000099.
PMID: 26204172BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 27, 2016
First Posted
July 25, 2016
Study Start
September 1, 2007
Primary Completion
March 1, 2009
Study Completion
July 1, 2009
Last Updated
July 25, 2016
Record last verified: 2016-07