The Effects of Acute vs. Chronic of Screen Illumination on: Sleep Efficacy and Architecture, Physiology, Emotion and Behavior: Possible Effect on Human Health

NCT02839395 | Completed

• 1 other identifier: 0005-16-ASMC
• Study Type: interventional
• Target: 19
• Locations: 0 countries
• Sites: N/A

Brief Summary

The human eye has a dual role, which is reflected by the various photo-receptors used for vision of images and colors ,Image forming photoreceptors (IFP) and for entrainment of our "Biological clock" located in the hypothalamus through the retinal ganglions known as non-image forming photoreceptors (NIFP). The recently discovered new photo-pigment melanopsin which is sensitive to short wavelength (SWL) illumination exists in the-NIFP. The axons of the NIFP form a special nerve known as the Retino-hypothalamic-tract (RHT) that transfers the SWL signal to the biological clock resulting in suppression of pineal melatonin (MLT) production. This is the basic mechanism by which environmental light/dark cycles entrain the biological clock and transfer the message to organs, tissues and cell. The American Medical Association (AMA) issued a resolution in 2012 stating that light at night constitutes environmental pollution because it violates the daily cycles, including the waking and sleeping cycles, and suppresses the secretion of melatonin from the pineal gland at night. Results of other studies have shown that exposure to artificial light at night (ALAN) and mainly those emerging from SWL sources suppresses MLT-produced in the pineal gland. Computers, tablets, TVs, and smart-phones screens emit SWL illumination, during the day and night hours, whether as active or passive users. The results of previous studies show that, exposure to SWL-ALAN illumination suppresses MLT-secretion and disrupts sleep patterns. In order to understand better the effect of SWL-exposure emerging from screens on human behavior and health, the investigators will study the effects of SWL-exposure on the structure and quality of sleep, cognitive functioning in Continous Performance Test (CPT III), emotional state, and physiological, variables (melatonin secretion levels and body temperature) that were not tested in previous studies.

Conditions

Sleep; Emotion

Keywords

screen illumination; melatonin; body temperature; cognitive functioning; light pollution

Outcome Measures

Primary Outcomes (15)

• body temperature

  body temperature in celsius degree.physiological marker

  12 hours

• Melatonin secretion

  Melatonin -Sulfate Urine ELISA 6-SMT ng/ml. physiological marker

  12 hours

• sleepiness

  ESS questionnaire score- number

  1 day

• BSI Questionnaire

  assess the subject's emotional state- number

  1 day

• Subjective sleepiness

  KSS questionnaire-number

  1 day

• attention

  a neuropsychological computerized attention and concentration test, designed to test attentional functions. number

  1 hour

• total Sleep time

  total sleep time in minutes. physiological marker

  1 night

• Sleep efficiency

  percentage of sleep efficiency- physiological marker

  1 night

• sleep latency to sleep stage1

  time in minute to sleep stage 1. physiological marker

  1 night

• sleep latency to sleep stage2

  time in minute to sleep stage 2. physiological marker

  1 night

• wake %TIB

  percentage of wake from Time in bed. physiological marker

  1 night

• REM %TIB

  percentage of REM from Time in bed. physiological marker

  1 night

• staege1%TIB

  percentage of sleep stage1 from Time in bed. physiological marker

  1 night

• stage2%TIB

  percentage of sleep stage2 from Time in bed.physiological marker

  1 night

• stage4%TIB

  percentage of sleep stage4 from Time in bed.physiological marker

  1 night

Study Arms (3)

base line

ACTIVE COMPARATOR

First night is the base line- no exposure to computer screen illumination.

Other: No intervention- base line

Acute

EXPERIMENTAL

Second night is the acute exposure to computer screen illumination.

Other: Acute

Chronic

EXPERIMENTAL

Chronic is the effect after five nights of exposure to computer screen light illumination.

Other: Chronic

Interventions

No intervention- base line OTHER

the subject will sited in a dim light room. No screen light illumination.

base line

Acute OTHER

The subject will be sited in front of computer screen light illumination for 2 hours.

Acute

Chronic OTHER

The subject will be sited in front of computer screen light illumination for 2 hours for 5 consecutive days.

Chronic

Eligibility Criteria

• Age: 20 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• age 20-45,
• healthy
• No history of visual disturbances
• No history of sleep disorders

You may not qualify if:

• score more then 5 in the Pittsburgh Questionnaire (PSQI).
• Subjects with a-typicality deviation in the HORNE - OSTBERG sleep-wakefulness cycle questionnaire.
• One of the Eye problems: field of vision, color blindness, or impaired functioning of the pupil in reaction to light.
• Subjects who did shiftwork three months before the experiment
• Subjects that taking sleeping medications in general and melatonin in particular

Sponsors & Collaborators

• Assuta Medical Center: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: July 7, 2016
• First Posted: July 21, 2016
• Study Start: August 1, 2016
• Primary Completion: October 1, 2016
• Study Completion: December 1, 2016
• Last Updated: January 9, 2018

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will not share