Herpes Zoster Prevalence in Frailty Consultations

NCT02832986 | Completed

• 1 other identifier: RC31-15-7581
• Study Type: observational
• Target: 1,245
• Locations: 1 country
• Sites: 1

Brief Summary

Herpes zoster and post herpetic pain are common causes of morbidity in the elderly. Herpes zoster is caused by reactivation of the virus varicella zoster of latent infection in sensory ganglia. The acute phase of herpes zoster usually occurs ≤ 30 days after rash onset. However, the most common complication of herpes zoster is the post herpetic pain, which is usually defined as a persistent chronic pain for ≥ 3 months after rash onset. The risk of herpes zoster in life is 25-30%, but this figure rises to 50% among those aged ≥ 85 years. Similarly, the risk of experiencing post herpetic pain increases with age. Despite treatment with antiviral drugs, post herpetic pain has been reported in 10-20% of all patients with herpes zoster, but its incidence increases significantly in elderly patients over 60 years. It can be particularly harmful when it occurs on a particular field, elderly multiple pathologies, fragile and with multiple treatment. In this context of decompensation "cascade" greatly exacerbate the impact of the initial local disease. Ophthalmologic involvement is rare but clinically worrisome and generates significant costs.

Conditions

Herpes Zoster

Keywords

Frailty consultation

Outcome Measures

Primary Outcomes (1)

• Frequence of zoster antecedent as assessed by percentage of subject with zoster antecedent

  During the frailty consultation

  Day 1

Secondary Outcomes (5)

• Frequence of ophthalmic zoster antecedent as assessed by percentage of subject with ophthalmic zoster antecedent

  Day 1

• Frequence of postherpetic pain antecedent as assessed by percentage of subject with postherpetic pain antecedent

  Day 1

• Risk factor associated with herpes zoster antecedent by usage of logistic regression model

  Through the completion of study (12 months)

• Risk factor associated with postherpetic pain by usage of logistic regression model

  Through the completion of study (12 months)

• Risk factor associated with ophthalmic zoster by usage of logistic regression model

  Through the completion of study (12 months)

Study Arms (1)

Patients in frailty consultation

Patients consulting in frailty consultation, at this occasion they will complete a medical questionary for the collection of study data

Other: Medical Questionary

Interventions

Medical Questionary OTHER

The medical questionary will contain : * Date of initial infection by Herpes zoster * Localisation * Severity * Presence of postherpetic pain * Postherpetic pain Intensity * Postherpetic pain duration * Antiviral treatment * History of chronic pathologies * Concomitant treatment

Patients in frailty consultation

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients consulting in frailty consultation

You may not qualify if:

• Patients not consulting daily hospital of fragility and dependence prevention
• Patients vaccinated against zoster

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

University Hospital of Toulouse - geriatric pole

Toulouse, 31059, France

Location

MeSH Terms

Conditions

Herpes Zoster

Condition Hierarchy (Ancestors)

Varicella Zoster Virus Infection; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections

Study Officials

• Bruno VELLAS, MD

  University Hospital of Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 1, 2016
• First Posted: July 14, 2016
• Study Start: January 1, 2015
• Primary Completion: December 1, 2015
• Study Completion: June 1, 2016
• Last Updated: July 14, 2016

Record last verified: 2016-07

Locations

FR (1)