The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults

NCT02825823 | Completed

• 1 other identifier: H1601260
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone salt, is proposed to have ergogenic potential for high-intensity exercise performance but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone salts can alter fuel use during exercise and improve exercise performance.

Conditions

Exercise; Ketones; Dietary Supplements

Outcome Measures

Primary Outcomes (1)

• Respiratory Exchange Ratio (RER) during cycling exercise

  The RER during 18 minutes of steady-state exercise

  0-18 minutes

Secondary Outcomes (1)

• 10 km Cycling Time Trial Performance

  Following 18 minutes of steady-state exercise

Study Arms (2)

Ketone Salts

EXPERIMENTAL

Acute dose of beta-hydroxybutyrate potassium/sodium salt (0.2g beta-hydroxybutyrate/kg, 0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)

Dietary Supplement: Ketone Salt

Placebo

PLACEBO COMPARATOR

Acute dose of taste-matched placebo (0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)

Dietary Supplement: Placebo

Interventions

Ketone Salt DIETARY_SUPPLEMENT

Ketone Salts

Placebo DIETARY_SUPPLEMENT

Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Males aged 18-40
• Ability to understand and communicate in English to answer questionnaires and interact with the research assistant
• Physically active (defined by engaging in moderate-to-vigorous exercise at least 3 times per week, determined via validated questionnaire)

You may not qualify if:

• Diagnosed with diabetes or any other medical conditions that could affect metabolism.
• Diagnosed with heart disease or taking anti-hypertensive medications.
• Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)
• Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet
• Current consumption of ketone supplements
• Any other contraindication to vigorous exercise (identified via physical activity readiness questionnaire \[PAR-Q\])

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

University of British Columbia, Okanagan.

Kelowna, British Columbia, V1V 1V7, Canada

Location

MeSH Terms

Conditions

Motor Activity; Ketosis

Condition Hierarchy (Ancestors)

Behavior; Acidosis; Acid-Base Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 4, 2016
• First Posted: July 7, 2016
• Study Start: July 1, 2016
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: October 13, 2017

Record last verified: 2017-10

Locations

CA (1)