Effects of Laugh Therapy Associated to Cardiopulmonary Rehab

NCT02824120 | Unknown

• 1 other identifier: 13-0124
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

Laugh is more than visual and vocal behave, is always followed by a series of physiological changes, including contractions of musculoskeletal system, increase of cardiac frequency by catecholamine release and hyperventilation that promoves the increase of maximum breathing and oxygen saturation. Laugh therapy may be an alternative therapy, simple, and improve the quality of life of individuals can influence physiological and biochemical parameters of the human body.

Conditions

Ischemic Heart Disease

Keywords

ischemic heart disease; laugh therapy

Outcome Measures

Primary Outcomes (1)

• Cardiopulmonary exercise test

  The maximum functional capacity is measured by a maximal cardiopulmonary exercise test with expired gas analysis,in the treadmill Inbramed® KT 10200 (Porto Alegre, Brazil).

  48 months

Secondary Outcomes (1)

• Quality of life Questionnaire

  48 months

Study Arms (2)

Comedy

EXPERIMENTAL

patients in this group will watch a comedy film that will not exceed 30 minutes

Other: Comedy

Documentary

EXPERIMENTAL

patients in this group will watch a documentary film that will not exceed 30 minutes.

Other: Documentary

Interventions

Comedy OTHER

patients will watch comedy film

Comedy

Documentary OTHER

patients will watch a documentary film

Documentary

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ischemic heart disease diagnosis established by cardiac catheterization, with 50% lesion in at least one epicardial vessel (if the patient has had an acute coronary syndrome or have been revascularized, the event time is expected to exceed 6 months).
• Both sexes
• With availability to come to HCPA twice a week
• In conditions of entering into a cardiac rehabilitation program with exercise.

You may not qualify if:

• Involvement in another clinical trial.
• Presence of autoimmune disease
• Use of oral anticoagulant
• Valvulopathy with mechanical or biological cardiac prosthesis
• Presence pacemaker or implantable cardioverter
• Left bundle branch block in 12-lead ECG
• severe lung disease
• Major Depression or Bipolar Disorder
• Chronic Atrial Fibrillation
• Left ventricular dysfunction (ejection fraction \<45%)
• Active infection or cancer (other than basal cell carcinoma)
• Chronic Renal Failure
• Illiteracy
• Inability to understand the consent form

Sponsors & Collaborators

• Hospital de Clinicas de Porto Alegre: lead

Study Sites (1)

Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

RECRUITING

Related Publications (22)

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  PMID: 16442885 BACKGROUND

• Briffa TG, Eckermann SD, Griffiths AD, Harris PJ, Heath MR, Freedman SB, Donaldson LT, Briffa NK, Keech AC. Cost-effectiveness of rehabilitation after an acute coronary event: a randomised controlled trial. Med J Aust. 2005 Nov 7;183(9):450-5. doi: 10.5694/j.1326-5377.2005.tb07121.x.

  PMID: 16274344 BACKGROUND

• Yeh GY, Wood MJ, Lorell BH, Stevenson LW, Eisenberg DM, Wayne PM, Goldberger AL, Davis RB, Phillips RS. Effects of tai chi mind-body movement therapy on functional status and exercise capacity in patients with chronic heart failure: a randomized controlled trial. Am J Med. 2004 Oct 15;117(8):541-8. doi: 10.1016/j.amjmed.2004.04.016.

  PMID: 15465501 BACKGROUND

• O'Connor GT, Buring JE, Yusuf S, Goldhaber SZ, Olmstead EM, Paffenbarger RS Jr, Hennekens CH. An overview of randomized trials of rehabilitation with exercise after myocardial infarction. Circulation. 1989 Aug;80(2):234-44. doi: 10.1161/01.cir.80.2.234.

  PMID: 2665973 BACKGROUND

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  PMID: 14652490 BACKGROUND

• Martin RA. Humor, laughter, and physical health: methodological issues and research findings. Psychol Bull. 2001 Jul;127(4):504-19. doi: 10.1037/0033-2909.127.4.504.

  PMID: 11439709 BACKGROUND

• Piegas LS, Avezum A, Pereira JC, Neto JM, Hoepfner C, Farran JA, Ramos RF, Timerman A, Esteves JP; AFIRMAR Study Investigators. Risk factors for myocardial infarction in Brazil. Am Heart J. 2003 Aug;146(2):331-8. doi: 10.1016/S0002-8703(03)00181-9.

  PMID: 12891204 BACKGROUND

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  PMID: 26375058 BACKGROUND

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  PMID: 17443363 BACKGROUND

• Clark A, Seidler A, Miller M. Inverse association between sense of humor and coronary heart disease. Int J Cardiol. 2001 Aug;80(1):87-8. doi: 10.1016/s0167-5273(01)00470-3.

  PMID: 11575268 BACKGROUND

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  PMID: 1545471 BACKGROUND

• Lebowitz KR, Suh S, Diaz PT, Emery CF. Effects of humor and laughter on psychological functioning, quality of life, health status, and pulmonary functioning among patients with chronic obstructive pulmonary disease: a preliminary investigation. Heart Lung. 2011 Jul-Aug;40(4):310-9. doi: 10.1016/j.hrtlng.2010.07.010.

  PMID: 21724041 BACKGROUND

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  PMID: 18488442 BACKGROUND

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  PMID: 19826144 BACKGROUND

• Vlachopoulos C, Xaplanteris P, Alexopoulos N, Aznaouridis K, Vasiliadou C, Baou K, Stefanadi E, Stefanadis C. Divergent effects of laughter and mental stress on arterial stiffness and central hemodynamics. Psychosom Med. 2009 May;71(4):446-53. doi: 10.1097/PSY.0b013e318198dcd4. Epub 2009 Feb 27.

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• Sugawara J, Tarumi T, Tanaka H. Effect of mirthful laughter on vascular function. Am J Cardiol. 2010 Sep 15;106(6):856-9. doi: 10.1016/j.amjcard.2010.05.011.

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• Hayashi K, Hayashi T, Iwanaga S, Kawai K, Ishii H, Shoji S, Murakami K. Laughter lowered the increase in postprandial blood glucose. Diabetes Care. 2003 May;26(5):1651-2. doi: 10.2337/diacare.26.5.1651. No abstract available.

  PMID: 12716853 BACKGROUND

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• Berk LS. Studying the biology of hope: An interview with Lee S. Berk, DrPH, MPH. Interview by Sheldon Lewis. Adv Mind Body Med. 2007 Summer;22(2):28-31.

  PMID: 20664125 BACKGROUND

• Sakuragi S, Sugiyama Y, Takeuchi K. Effects of laughing and weeping on mood and heart rate variability. J Physiol Anthropol Appl Human Sci. 2002 May;21(3):159-65. doi: 10.2114/jpa.21.159.

  PMID: 12148458 BACKGROUND

MeSH Terms

Conditions

Myocardial Ischemia

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Officials

• Ricardo Stein, PhD

  Hospital de Clínicas de Porto Alegre

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rosane M. Nery, PhD

CONTACT

0555133597634; rosane.nery@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 22, 2016
• First Posted: July 6, 2016
• Study Start: June 1, 2013
• Primary Completion: March 1, 2019
• Study Completion: March 1, 2019
• Last Updated: August 21, 2018

Record last verified: 2018-07

Locations

BR (1)