Predictive Values of Serum Adiponectin Levels in Aneurysmal Subarachnoid Hemorrhage.
1 other identifier
observational
100
1 country
1
Brief Summary
The purpose of this study is to evaluate the predictive value of serum adiponectin levels in aneurysmal subarachnoid hemorrhage patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2016
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2016
CompletedFirst Submitted
Initial submission to the registry
May 2, 2016
CompletedFirst Posted
Study publicly available on registry
June 27, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2017
CompletedMarch 31, 2017
March 1, 2017
1.2 years
May 2, 2016
March 29, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Incidence of cerebral vasospasm and delayed cerebral ischemia
Proved by clinical and radiologic evidence
30 days post SAH
Secondary Outcomes (3)
Death
30 days post SAH
National institutes of health stroke scale (NIHSS) score
On discharge or 14 days (whichever occurs first) and 30 days post SAH
Modified Rankin scale (mRS)
30 days and 90days post SAH
Eligibility Criteria
Patients with aneurysmal subarachnoid hemorrhage who are hospitalized within 24 hours from onset.
You may qualify if:
- Age\>18yrs and age\<90yrs
- It shows subarachnoid hemorrhage (SAH) based on computed tomography (CT) scan on admission
- Aneurysmal subarachnoid hemorrhage confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA) or digital subtraction angiography (DSA)
- SAH grade is assessed by Hunt \& Hess classification
- Informed consented
You may not qualify if:
- Traumatic subarachnoid hemorrhage
- Patients with cerebral herniation or highly possible to occur within 2 days from SAH
- Length of hospital stay is expected to be less than 5 days
- Duration from onset to admission is more than 48 hours
- Disturbance of communication or poor compliance to blood collection, imaging examination and follow-up
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Tang-Du Hospitallead
Study Sites (1)
Tandu Hospital, Fourth Military Medical University
Xi'an, Shaanxi, 710038, China
Related Publications (7)
Thundyil J, Tang SC, Okun E, Shah K, Karamyan VT, Li YI, Woodruff TM, Taylor SM, Jo DG, Mattson MP, Arumugam TV. Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death. Exp Transl Stroke Med. 2010 Aug 11;2(1):15. doi: 10.1186/2040-7378-2-15.
PMID: 20701790BACKGROUNDOsuka K, Watanabe Y, Yasuda M, Takayasu M. Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage. Neurosci Lett. 2012 Apr 11;514(1):2-5. doi: 10.1016/j.neulet.2011.12.041. Epub 2012 Jan 3.
PMID: 22230897BACKGROUNDPsilopanagioti A, Papadaki H, Kranioti EF, Alexandrides TK, Varakis JN. Expression of adiponectin and adiponectin receptors in human pituitary gland and brain. Neuroendocrinology. 2009;89(1):38-47. doi: 10.1159/000151396. Epub 2008 Aug 13.
PMID: 18698133BACKGROUNDKos K, Harte AL, da Silva NF, Tonchev A, Chaldakov G, James S, Snead DR, Hoggart B, O'Hare JP, McTernan PG, Kumar S. Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus. J Clin Endocrinol Metab. 2007 Mar;92(3):1129-36. doi: 10.1210/jc.2006-1841. Epub 2007 Jan 9.
PMID: 17213280BACKGROUNDKusminski CM, McTernan PG, Schraw T, Kos K, O'Hare JP, Ahima R, Kumar S, Scherer PE. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia. 2007 Mar;50(3):634-42. doi: 10.1007/s00125-006-0577-9. Epub 2007 Jan 23.
PMID: 17242917BACKGROUNDEfstathiou SP, Tsioulos DI, Tsiakou AG, Gratsias YE, Pefanis AV, Mountokalakis TD. Plasma adiponectin levels and five-year survival after first-ever ischemic stroke. Stroke. 2005 Sep;36(9):1915-9. doi: 10.1161/01.STR.0000177874.29849.f0. Epub 2005 Aug 18.
PMID: 16109902BACKGROUNDTakeuchi S, Wada K, Otani N, Osada H, Nagatani K, Mori K. Temporal profile of plasma adiponectin level and delayed cerebral ischemia in patients with subarachnoid hemorrhage. J Clin Neurosci. 2014 Jun;21(6):1007-10. doi: 10.1016/j.jocn.2013.10.020. Epub 2013 Dec 22.
PMID: 24594449BACKGROUND
Biospecimen
blood
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 2, 2016
First Posted
June 27, 2016
Study Start
April 1, 2016
Primary Completion
June 1, 2017
Study Completion
August 1, 2017
Last Updated
March 31, 2017
Record last verified: 2017-03
Data Sharing
- IPD Sharing
- Will not share