NCT02807662

Brief Summary

The objectives of this research study are to screen 750 pregnant women at risk of trauma-related stress symptoms, and adapt and test an evidence-based intervention for pregnant women with PTSD and sub-threshold PTSD symptoms served by two public payer community health centers.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
149

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Feb 2012

Longer than P75 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2012

Completed
3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2015

Completed
1 year until next milestone

First Submitted

Initial submission to the registry

June 14, 2016

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 21, 2016

Completed
Last Updated

June 21, 2016

Status Verified

June 1, 2016

Enrollment Period

3.3 years

First QC Date

June 14, 2016

Last Update Submit

June 16, 2016

Conditions

Keywords

posttraumatic stress disorderprenatal care

Outcome Measures

Primary Outcomes (3)

  • Change in posttraumatic stress disorder symptoms

    The primary endpoint is one month postpartum

  • Preterm labor

    the primary endpoint is one month postpartum

  • Birthweight

    the primary endpoint is one month postpartum

Secondary Outcomes (3)

  • Number of visits for prenatal care

    the primary end point is one month postpartum

  • Change in depression symptoms

    the primary endpoint is one month postpartum

  • change in coping strategies inventory

    the primary endpoint is one month postpartum

Study Arms (2)

Experimental

EXPERIMENTAL

Intervention mothers receive adapted Seeking Safety intervention delivered by prenatal care advocate over 8 sessions

Behavioral: Adapted Seeking Safety Intervention

No intervention

NO INTERVENTION

Treatment as usual mothers receive usual services of a prenatal care advocate

Interventions

Intervention participants received Seeking Safety psychosocial education Intervention adapted for prenatal care setting.

Experimental

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Mothers who are receiving prenatal care
  • years or older
  • In the first 20 weeks of pregnancy
  • Screen positive for posttraumatic stress disorder

You may not qualify if:

  • Not pregnant
  • Not currently psychotic
  • No current suicidal ideation
  • Language other than English, Spanish, Vietnamese, and Portuguese

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (2)

  • Jones KA, Freijah I, Brennan SE, McKenzie JE, Bright TM, Fiolet R, Kamitsis I, Reid C, Davis E, Andrews S, Muzik M, Segal L, Herrman H, Chamberlain C. Interventions from pregnancy to two years after birth for parents experiencing complex post-traumatic stress disorder and/or with childhood experience of maltreatment. Cochrane Database Syst Rev. 2023 May 4;5(5):CD014874. doi: 10.1002/14651858.CD014874.pub2.

  • Weinreb L, Wenz-Gross M, Upshur C. Postpartum outcomes of a pilot prenatal care-based psychosocial intervention for PTSD during pregnancy. Arch Womens Ment Health. 2018 Jun;21(3):299-312. doi: 10.1007/s00737-017-0794-x. Epub 2017 Nov 7.

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic

Condition Hierarchy (Ancestors)

Stress Disorders, TraumaticTrauma and Stressor Related DisordersMental Disorders

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 14, 2016

First Posted

June 21, 2016

Study Start

February 1, 2012

Primary Completion

June 1, 2015

Study Completion

June 1, 2015

Last Updated

June 21, 2016

Record last verified: 2016-06

Data Sharing

IPD Sharing
Will not share