Neural Indices Associated With Relapse in Cannabis Dependence
Altered Neural Activation Patterns of Emotional Processing in Dependent Cannabis Users Associated With Relapse
1 other identifier
observational
75
1 country
1
Brief Summary
The aim of this fMRI study is to investigate neural indices of relapse in cannabis dependence. The development and maintenance of drug addictions have been associated with deficits in cognitive control, craving and impaired stress regulation. Therefore, neural markers of brain processes underlying the beforementioned components will be studied. Subsequent follow-up drug use interviews will reveal associations between relapse in cannabis dependence and alterations in brain networks of cognitive control, craving and stress.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Feb 2016
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2016
CompletedFirst Submitted
Initial submission to the registry
June 11, 2016
CompletedFirst Posted
Study publicly available on registry
June 15, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2019
CompletedOctober 29, 2018
October 1, 2018
3.1 years
June 11, 2016
October 26, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
fMRI neural activation patterns of emotional processing
Activation patterns associated with emotion processing, emotion regulation, craving and stress are determined in addicted cannabis users compared to non-using matched control subjects
one time point = fMRI assessment after minimum 24 hours of abstinence
Secondary Outcomes (1)
Timeline Followback Interviews
one time point = 12 months after fMRI data acquisition
Study Arms (2)
Cannabis Dependence
ages 18-40
Healthy control subjects
socio-demographically matched
Interventions
Eligibility Criteria
Cannabis dependent individuals
You may qualify if:
- Cannabis Dependence
- hours abstinence
You may not qualify if:
- other DSM-4 diagnosis
- neurological disorder
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Electronic Science and Technology of Chinalead
- German Research Foundationcollaborator
- University Hospital, Bonncollaborator
Study Sites (1)
University of Bonn
Bonn, North Rhine Westfalia, 53127, Germany
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Dr. rer. nat. Benjamin Becker
Study Record Dates
First Submitted
June 11, 2016
First Posted
June 15, 2016
Study Start
February 1, 2016
Primary Completion
March 1, 2019
Study Completion
March 1, 2019
Last Updated
October 29, 2018
Record last verified: 2018-10