Social and Emotional Brain Function in Cannabis Users

NCT02711371 | Completed

• 1 other identifier: ART_Can_01
• Study Type: observational
• Target: 43
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this functional magnetic resonance imaging (fMRI) study is to find out whether and how social and emotional brain function are altered in dependent cannabis users relative to healthy non-using control subjects after a 28 supervised abstinence period. Previous research in cannabis users has predominantly focused on cognitive functions. Moreover, studies have implicated that observed deficits in cannabis users may regenerate after a prolonged abstinence period. Findings might provide important information with respect to relapse vulnerability.

Conditions

Cannabis Dependence

Keywords

addiction; cannabis; fMRI

Outcome Measures

Primary Outcomes (1)

• fMRI neural activation patterns of social-emotional brain processes after 28 day abstinence

  Activity patterns in core regions of the emotion processing \& addiction-related brain networks (e.g. striatal regions, insular cortex, prefrontal cortex) will be assessed after 28-days of abstinence. Alterations will be determined by comparison with matched non-drug using controls

  one timepoint = fMRI assessment after 28 day abstinence period

Secondary Outcomes (2)

• Ratings of subjective experience (pleasantness, rewarding value) will be assessed after 28 days of abstinence

  one timepoint = during fMRI assessment after 28 day abstinence period

• Relapse interview assessed with Timeline-Followback Method

  one timepoint = 24 months post-fMRI-session

Study Arms (2)

Cannabis Dependence

Cannabis dependent individuals according to DSM 4 criteria, aged 18-40 years

Other: fMRI

Healthy

Healthy controls, socio-demographically matched

Other: fMRI

Interventions

fMRI OTHER

Cannabis Dependence; Healthy

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Cannabis dependent individuals

You may qualify if:

• Cannabis dependence according to DSM 4 criteria
• days of supervised abstinence

You may not qualify if:

• other DSM 4 diagnosis
• neurological disorders

Sponsors & Collaborators

• University of Electronic Science and Technology of China: lead
• German Research Foundation: collaborator
• University Hospital, Bonn: collaborator

Study Sites (1)

University of Bonn / Department of Psychiatry

Bonn, North Rhine-Westphalia, 53111, Germany

Location

Related Publications (1)

• Zimmermann K, Yao S, Heinz M, Zhou F, Dau W, Banger M, Weber B, Hurlemann R, Becker B. Altered orbitofrontal activity and dorsal striatal connectivity during emotion processing in dependent marijuana users after 28 days of abstinence. Psychopharmacology (Berl). 2018 Mar;235(3):849-859. doi: 10.1007/s00213-017-4803-6. Epub 2017 Dec 2.

  PMID: 29197984 DERIVED

MeSH Terms

Conditions

Marijuana Abuse; Behavior, Addictive

Condition Hierarchy (Ancestors)

Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders; Compulsive Behavior; Impulsive Behavior; Behavior

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr. rer. nat.

Study Record Dates

• First Submitted: March 4, 2016
• First Posted: March 17, 2016
• Study Start: July 1, 2015
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: February 2, 2017

Record last verified: 2017-02

Locations

DE (1)