Trials Sponsors Conditions Drugs Pricing

Conditions

Loss of Consciousness

Keywords

PropofolDexmedetomidineDoseBispectral index monitor

Outcome Measures

Primary Outcomes (1)

The propofol requirement for pretreatment of dexmedetomidine by micro-pump until loss of consciousness
To infuse dexmedetomidine and saline completely ten minutes after

Secondary Outcomes (1)

The bispectral index values when patients loss of consciousness
To infuse dexmedetomidine and saline completely ten minutes after

Study Arms (3)

Group control

PLACEBO COMPARATOR

24 eligible patients are received equal volumes of saline intravenously for 10 minutes

Other: normal saline

Group dexmedetomidine 0.5 µg/kg

ACTIVE COMPARATOR

24 eligible patients are received dexmedetomidine 0.5 µg/kg intravenously for 10 minutes

Drug: dexmedetomidine 0.5 µg/kg

Group dexmedetomidine 1.0 µg/kg

ACTIVE COMPARATOR

25 eligible patients are received dexmedetomidine 1.0 µg/kg intravenously for 10 minutes

Interventions

normal salineOther

receive equal volume of normal saline

Group control

dexmedetomidine 0.5 µg/kgDrug

receive dexmedetomidine 0.5 µg/kg

Group dexmedetomidine 0.5 µg/kg

Eligibility Criteria

Age18 Years - 65 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

ASA physical status I-II
Aged 18-65 years

Sponsors & Collaborators

General Hospital of Ningxia Medical University
Otherlead

Related Publications (1)

Gu Y, Yang F, Zhang Y, Zheng J, Wang J, Li B, Ma T, Cui X, Lu K, Ma H. The effects of different doses of dexmedetomidine on the requirements for propofol for loss of consciousness in patients monitored via the bispectral index: a double-blind, placebo-controlled trial. BMC Anesthesiol. 2020 Apr 25;20(1):96. doi: 10.1186/s12871-020-01013-x.
PMID: 32334510DERIVED

MeSH Terms

Conditions

Unconsciousness

Interventions

Saline SolutionDexmedetomidine

Condition Hierarchy (Ancestors)

Consciousness DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Crystalloid SolutionsIsotonic SolutionsSolutions

Enrollment

73 participants (actual enrollment reported by the registry).

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: TRIPLE
Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose: PREVENTION
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

May 16, 2016

First Posted

May 26, 2016

Study Start

June 2016

Date type not reported

This date has not been verified as actual or estimated.

The Effects of Different Doses of Dexmedetomidine on Propofol Requirement for Loss of Consciousness Undergoing Bispectral Index: a Double-blinded, Placebo-controlled Trial

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (3)

Group control

Group dexmedetomidine 0.5 µg/kg

Group dexmedetomidine 1.0 µg/kg

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Related Publications (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (3)

Group control

Group dexmedetomidine 0.5 µg/kg

Group dexmedetomidine 1.0 µg/kg

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Related Publications (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Intervention Hierarchy (Ancestors)

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record