NCT02125214|CompletedDMC
Alteration of Temporal Organization of EEG Microstate Sequences During Propofol-induced Loss of Consciousness
Fractal
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Fractal
Sponsor study identifier
interventional
20
1 country
1
Study Start
January 2014
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
April 2015
Actual (reported)Study Completion
April 2015
Actual (reported)Temporal dynamics of the EEG microstates show scale-free monofractal properties. This means that information is encoded in the same way at different scales. It may be postulated that these monofractal properties of the EEG microstate sequences constitute a necessary prerequisite of consciousness. We postulate that clinical variations of consciousness may also be linked to alterations of fractal properties of EEG microstates.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2015
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2014
Date type not reportedThis date has not been verified as actual or estimated.
April 24, 2014
Actual (reported)April 29, 2014
Actual (reported)April 2015
Actual (reported)April 2015
Actual (reported)EEG microstates
Assess the alteration of temporal organization of EEG microstate sequences during propofol-induced loss of consciousness.
45 minutes
ASA 1-2 patients 20-40 yr
Intravenous induction with propofol using the pharmacokinetic model by Schnider et al. The initial cerebral concentration will be 0.5 µg ml-1, which will be increased stepwise by 1.0 µg ml-1 until 2.5 µg ml-1, and then by 0.5 µg ml-1 until loss of consciousness
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University Hospitals of Geneva
Geneva, Canton of Geneva, 1206, Switzerland
Britz J, Van De Ville D, Michel CM. BOLD correlates of EEG topography reveal rapid resting-state network dynamics. Neuroimage. 2010 Oct 1;52(4):1162-70. doi: 10.1016/j.neuroimage.2010.02.052. Epub 2010 Feb 24.
Martin Tramer, MD, DPhil
University Hospitals of Geneva, Department of Anesthesiology
Julien Maillard, MD
University Hospitals of Geneva, Department of Anesthesiology
20 participants (actual enrollment reported by the registry).
First Submitted
April 24, 2014
First Posted
April 29, 2014
Study Start
January 2014
Date type not reportedThis date has not been verified as actual or estimated.
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Primary Completion
April 2015
Actual (reported)Study Completion
April 2015
Actual (reported)Last Updated
June 1, 2015
Record last verified: 2015-05
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