Age Related Changes in Cardiac Physiology as a Predictor of Exercise Tolerance

NCT02779972 | Completed

• 1 other identifier: TASMC-16-UC-0090-16-TLV-CTIL
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Aging is associated with numerous changes and adaptations in the cardiovascular system. Vascular and ventricular wall thickness increase, whereas arterial compliance, endothelial function, and ventricular contractility decline. The decline in cardiac function with advancing age is typically seen in parallel to reduced physical activity, and it has been proposed that lifelong exercise training might attenuate the effects of aging on the heart. The cardiovascular system undergoes several age-related changes. For most healthy older individuals, the heart generally functions well under resting conditions. Structural and physiological changes tend to result in diminished exercise tolerance. However, increasingly it has been shown that even some of these changes are more a result of a sedentary lifestyle than an age-related phenomenon. Most elderly people tend to become less physically active. It is difficult to separate changes intrinsic to the aging process from those arising as a result of a sedentary lifestyle.

Conditions

Aging; Exercise Tolerance

Keywords

Cardiac Physiology; Physiology

Outcome Measures

Primary Outcomes (1)

• Cardiac output at maximal stress test

  mean cardiac output in liter per minute for each age group

  45 minutes

Study Arms (3)

60's decade

60's decade Echo stress test

Other: Echo stress test

70's decade

70's decade Echo stress test

Other: Echo stress test

80's decade

80's decade Echo stress test

Other: Echo stress test

Interventions

Echo stress test OTHER

Echo stress test

60's decade; 70's decade; 80's decade

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients above 65 with preserved systolic function and stress echo on a treadmill between 1 Jan 2012 until 31 Dec 2015 in our facility

You may qualify if:

• All patients above 65 with preserved systolic function and stress echo on a treadmill between 1 Jan 2012 until 31 Dec 2015 in the facility.

You may not qualify if:

• Missing complete information used for data collection.

Sponsors & Collaborators

• Tel-Aviv Sourasky Medical Center: lead

Study Sites (1)

The Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

Location

Study Officials

• Ehud Chorin, MD

  972-3-6947520

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director. Research & Development

Study Record Dates

• First Submitted: May 17, 2016
• First Posted: May 23, 2016
• Study Start: March 1, 2016
• Primary Completion: January 30, 2018
• Study Completion: February 4, 2018
• Last Updated: February 15, 2018

Record last verified: 2018-02

Data Sharing

• IPD Sharing: Will not share

Locations

IL (1)