Osteochondritis Dissecans of Knee Prospective Cohort
ROCK Comprehensive Prospective Cohort for Osteochondritis Dissecans of the Knee
1 other identifier
observational
3,000
1 country
1
Brief Summary
The Cohort is a multi-site prospective data collection study that will enroll any patient with diagnosis of knee OCD (confirmed by a standard of care x-ray or MRI). Patients will be followed for up to the next 50 years of their lives to study courses of care, disease progression, treatment/surgical options/results, and specific sports-related outcomes in athletic patients. Subjects will complete quality of life surveys as part of the Cohort. Course of care will not be affected.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2014
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2014
CompletedFirst Submitted
Initial submission to the registry
May 10, 2016
CompletedFirst Posted
Study publicly available on registry
May 13, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2064
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2064
April 3, 2025
March 1, 2025
50 years
May 10, 2016
March 28, 2025
Conditions
Outcome Measures
Primary Outcomes (2)
IKDC questionnaire
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
baseline up to 50 years
PEDI-IKDC questionnaire
The primary outcome endpoint for this study is the patient's score on the IKDC Subjective questionnaire, or PEDI-IKDC Subjective questionnaire for patients under 18 years of age.
baseline up to 50 years
Secondary Outcomes (4)
KOOS Knee score
baseline up to 50 years
Marx Activity Score questionnaire
baseline up to 50 years
Pedi-FABS Score
baseline up to 50 years
Radiographic Healing
baseline up to 50 years
Study Arms (1)
Patients with OCD
Patients with diagnosis of OCD as confirmed by x-ray or MRI. Surveys collected from patients at 2 years, 5 years, 10 years, and 25 years.
Interventions
Other: observational only- no intervention
Eligibility Criteria
Patients of all ages with osteochondritis dissecans (OCD) or focal articular cartilage defects confirmed via MRI or x-ray.
You may qualify if:
- Diagnosis of osteochondritis dissecans or focal articular cartilage defects as confirmed by x-ray or MRI
You may not qualify if:
- Non-confirmed diagnosis (i.e. patient does not yet have imaging confirmation)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Pennsylvanialead
- Altona Children's Hospitalcollaborator
- Boston Children's Hospitalcollaborator
- Children's Hospital Medical Center, Cincinnaticollaborator
- Children's Health Andrews Institute for Orthopaedics & Sports Medicinecollaborator
- Children's Healthcare of Atlantacollaborator
- Children's Hospital Coloradocollaborator
- Children's Hospital of Philadelphiacollaborator
- Children's Hospital and Health System Foundation, Wisconsincollaborator
- Children's Mercy Hospital Kansas Citycollaborator
- Connecticut Children's Medical Centercollaborator
- Hospital for Special Surgery, New Yorkcollaborator
- Kaiser Permanentecollaborator
- Mayo Cliniccollaborator
- National University Hospital, Singaporecollaborator
- Rady Children's Hospital, San Diegocollaborator
- Stanford Universitycollaborator
- Tennessee Orthopedic Alliancecollaborator
- Texas Scottish Rite Hospital for Childrencollaborator
- The Rocky Mountain Hospital for Childrencollaborator
- The Hospital for Sick Childrencollaborator
- Göteborg Universitycollaborator
- University of Minnesota/TRIA Orthopaedic Centercollaborator
- Washington University School of Medicinecollaborator
Study Sites (1)
University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
James L Carey, MD
University of Pennsylvania
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 10, 2016
First Posted
May 13, 2016
Study Start
May 1, 2014
Primary Completion (Estimated)
May 1, 2064
Study Completion (Estimated)
December 1, 2064
Last Updated
April 3, 2025
Record last verified: 2025-03