Microcirculation and Inflammatory Markers in Patients With Resistant, Stages 1/2 Hypertension and Normal Blood Pressure

NCT02759276 | Completed

• 2 other identifiers: RiodeJaneiro_StateUniversityBIOVASC-UERJ
• Study Type: observational
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

Nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and inflammatory biomarkers have been used to study endothelial function in patients with resistant hypertension, stages 1 and 2 hypertension and normotensive. This was a cross-sectional study.

Conditions

High Blood Pressure

Keywords

Nailfold Videocapillaroscopy; Venous Occlusion Plethysmography; Endothelial Function; Microcirculation; Inflammatory Biomarkers

Outcome Measures

Primary Outcomes (1)

• Blood Pressure (mmHg)

  Hemodynamic Variable

  1 day

Secondary Outcomes (18)

• Functional Capillary Density (FCD, number capillaries/mm2 )

  1 day

• Afferent Capillary Diameter (micrometer)

  1 day

• Apical Capillary Diameter (micrometer)

  1 day

• Efferent Capillary Diameter (micrometer)

  1 day

• Red Blood Cell Velocity (mm/s)

  1 day

Study Arms (3)

Resistant Hypertension (RH)

uncontrolled hypertension, with values ≥140/90 mmHg, using three or more antihypertensive drugs of different classes, including a diuretic, or controlled hypertension with four or more drugs.

Stages 1 and 2 Hypertension (MMH)

According to the VI Brazilian Guidelines of hypertension, with blood pressure levels ranging from 140/90 mmHg to 179/109 mmHg, with up to two antihypertensive drugs of different classes and blood pressure levels controlled in the last two months.

Normotensive (CG)

Blood Pressure \<140/90 mmHg and without comorbidities.

Eligibility Criteria

• Age: 27 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

First Day: Full clinical examination was performed, including measurements of at-rest blood pressure, weight and height in order to calculate Body Mass Index (BMI), waist and hip measurements. Second Day: drawing blood for laboratory analyses, Nailfold Videocapillaroscopy and Venous Occlusion Plethysmography.

You may qualify if:

• Clinical diagnosis of controlled High Blood Pressure stages 1 and 2 (blood pressure levels from 140/90 mmHg to 179/109 mmHg) .
• Resistant Hypertension (uncontrolled hypertension, with values ≥140/90 mmHg, using three or more antihypertensive drugs of different classes, including a diuretic, or controlled hypertension with four or more drugs).
• Normal Blood Pressure.

You may not qualify if:

• Diabetes Mellitus, Types 1 or 2.
• Heart Failure.
• Myocardial infarction or stroke with less than three months of the event.
• Chronic kidney disease.
• Use of hormonal or non-hormonal anti-inflammatory drugs.
• Recent trauma (less than three months).
• Autoimmune diseases.
• Infectious processes in activity.
• Neoplasia.
• Aspirin use (anti-inflammatory dose).
• Obesity grade III (Body Mass Index\>40 kg/m2).

Sponsors & Collaborators

• Daniel Alexandre Bottino: lead
• Rio de Janeiro State University: collaborator

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: M.D., PhD

Study Record Dates

• First Submitted: April 20, 2016
• First Posted: May 3, 2016
• Study Start: May 1, 2015
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: May 3, 2016

Record last verified: 2016-04

Data Sharing

• IPD Sharing: Will not share