Covert-saccades, Dynamic Visual Acuity and Quality of Life

NCT02753179 | Completed

• 1 other identifier: 69HCL15_0746
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with chronic bilateral vestibular hypofunction may suffer from a visual instability during head movement called oscillopsia. Visual consequence of vestibular deficit can lead to a severe impairment of their quality of life. However, correcting saccades during rapid head movement, called covert-saccades, have been more recently identified. These saccades, which occur during the head movement in patients with vestibular hypofunction, present a very short latency. They could compensate for the lack of vestibular-ocular reflex and greatly decrease oscillopsia and visual impairment. The objective of this study is to evaluate the potential functional benefice of these compensatory movements in a population of 20 patients with chronic bilateral areflexia, in a cross-sectional study.

Conditions

Vestibular Diseases

Keywords

Bilateral vestibular hypofunction; Video Head Impulse Test; Covert-saccades; Quality of life; Dynamic visual acuity

Outcome Measures

Primary Outcomes (1)

• Frequency of covert-saccades

  Frequency of covert saccades corresponds to the total amount of covert-saccades divided by the total amount of head impulse tests multiplied by 100.

  Day 0

Secondary Outcomes (4)

• Quality of life assessed with the Dizziness Handicap Inventory

  Day 0

• Dynamic visual acuity

  day 0

• Oscillopsia severity questionnaire score

  day 0

• Latency of covert-saccades

  Day 0

Study Arms (1)

Bilateral vestibular hypofunction

EXPERIMENTAL

Patients suffering from chronic bilateral vestibular hypofunction.

Other: Head Impulse Tests; Other: Dynamic visual acuity Test (DVAT); Other: VEMPs & VEMPo; Other: Dizziness Handicap Inventory; Other: Oscillopsia severity questionnaire

Interventions

Head Impulse Tests OTHER

Head Impulse Tests are performed by the clinician who holds the patient's head in his hands, while he is looking straight at an earth-fixed target; then by turning the patient's head abruptly and unpredictably to the left or right, up or down through a small angle (only 10-20 degrees - not a large angle). 20 impulses in each directions (6) will be performed.

Bilateral vestibular hypofunction

Dynamic visual acuity Test (DVAT) OTHER

Dynamic visual acuity Test (DVAT) assesses visual acuity during head movement relative to baseline static visual acuity. DVA will be assessed actively during self-generated rotations of the head in different directions.

Bilateral vestibular hypofunction

VEMPs & VEMPo OTHER

VEMPs \& VEMPo are sound evoked muscular contractions of the neck or eye. They are recorded using an evoked response computer, a sound generator, and surface electrodes to pick up neck or eye muscle activation.

Bilateral vestibular hypofunction

Dizziness Handicap Inventory OTHER

Dizziness Handicap Inventory is a questionnaire that identify difficulties that patient may be experiencing because of dizziness, yielding to a score ranging from 0 to 100

Bilateral vestibular hypofunction

Oscillopsia severity questionnaire OTHER

Oscillopsia severity questionnaire is a 9 items questionnaires that identify oscillopsia in different circumstances.

Bilateral vestibular hypofunction

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Bilateral Vestibular Hypofunction (BVH) with at least two of the tree following criteria
• Mean peak slow phase velocity of 5°/s or less in bilateral bithermal (30 and 44°C) caloric irrigations
• Pathologic Head-impulse test
• VOR gain of \<0.25 on rotatory chair tests
• Disorder present for over 6 month
• Comprehension of the experiments instructions
• Patient consent

You may not qualify if:

• Corrected Visual Acuity lower than 5/10
• Other conditions leading to oscillopsia or ataxia
• Oculomotor palsy, ocular instability in primary position
• Cervical rachis pathology with instability
• Cochlear Implants
• Non-stabilized medical disease
• Pregnant women
• Patients under tutelage

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Unité de Neuro-Ophtalmologie Hôpital Neurologique

Bron, 69500, France

Location

Related Publications (1)

• Hermann R, Pelisson D, Dumas O, Urquizar C, Truy E, Tilikete C. Are Covert Saccade Functionally Relevant in Vestibular Hypofunction? Cerebellum. 2018 Jun;17(3):300-307. doi: 10.1007/s12311-017-0907-0.

  PMID: 29248983 BACKGROUND

MeSH Terms

Conditions

Vestibular Diseases

Condition Hierarchy (Ancestors)

Labyrinth Diseases; Ear Diseases; Otorhinolaryngologic Diseases

Study Officials

• Caroline TILIKETE, MD

  Institut National de la Santé Et de la Recherche Médicale, France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 25, 2016
• First Posted: April 27, 2016
• Study Start: May 1, 2016
• Primary Completion: January 1, 2017
• Study Completion: January 1, 2017
• Last Updated: September 4, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)