Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease

NCT02752750 | Unknown

• 1 other identifier: QSM AD
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

In this explorative longitudinal study 50 patients with Alzheimer's disease (AD) and 50 age-matched control subjects will be recruited for their 2 years follow-ups and undergo extensive cognitive testing and quantitative 3 Tesla magnetic resonance imaging (MRI). Regional differences of susceptibility and R2\* relaxation rates in deep gray matter and the neocortex will be evaluated in AD patients and controls and related to the patients´ cognitive status at baseline.

Conditions

Alzheimer's Disease

Outcome Measures

Primary Outcomes (1)

• Quantitative magnetic susceptibility (QSM) in the human brain

  Reveal the dynamics of disease related brain iron deposition (by QSM in ppm) and its relation to disease progression and cognition.

  2 years

Study Arms (2)

AD_GROUP

Patients with Alzheimer's disease

Other: MRI

HC_GROUP

Healthy controls

Other: MRI

Interventions

MRI OTHER

MR imaging (MRI) at 3 Tesla

Also known as: Magnetic resonance imaging

AD_GROUP; HC_GROUP

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Alzheimer 's Disease

You may qualify if:

• diagnosis of dementia according to DSM-IV and NINCDS-ADRDA criteria
• the patient lives either with the family or has less than 40h/week of external care
• the patients is able to understand the role in this study and is willing to participate
• the physician in charge of this study confirms that the patients understands the study and its aims according to cognitive and clinical testing

You may not qualify if:

• are other disorders
• participation in a clinical drug trial (phase 1-3)

Sponsors & Collaborators

• Medical University of Graz: lead

MeSH Terms

Conditions

Alzheimer Disease

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Christian Langkammer, PhD

  Medical University of Graz

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 19, 2016
• First Posted: April 27, 2016
• Study Start: May 1, 2016
• Primary Completion: May 1, 2024
• Study Completion: May 1, 2025
• Last Updated: September 21, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share