Effects of Caffeine and Coffee on Resting Metabolic Rate, Comparing Normal Weight Men to Obese Men

NCT02751840 | Completed Phase 3

• 1 other identifier: Tel Hai College RMR-011
• Study Type: interventional
• Target: 33
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background. The prevalence of obesity has increased in the last two decades. To maintain body weight energy expenditure (EE) should be equal to energy intake (EI). A low EE predisposes individuals to weight gain and to obesity that can also results from low resting metabolic rate (RMR). Caffeine (Caf) is an active food ingredient and is widely consumed globally, and has an important impact on energy balance. Caf reduces appetite (EI) and increases EE, thus, Caf has a potential role in body weight reduction. Caf causes higher total daily energy expenditure (TDEE) in normal weight (NW) people compared to obese (OW). Moreover Caf is linked to decreased fat oxidation in OW. There are differences between OW and NW in Caf pharmacokinetics, but no differences reported between NW and OW females in its effects on RMR. There is a gender difference in the influence of Caf on metabolism. The investigators are aware of no previous studies which compared the effect of Caf on the RMR of NW and OW men. Objectives. 1) To compare the effect of Caf and coffee on resting metabolic rate (RMR) values in healthy normal-weight (NW) men and overweight (OW) men. 2) To develop Caf intake frequency questionnaire (in Hebrew) Hypothesis. RMR values will be higher and respiratory exchange ratio (RER) values will be lower in NW compared to the values measured in OW men. Methods. 33 men (16 NW and 17 OW) were reported to the laboratory on 4 separate occasions (placebo, Caf tablets, coffee and decaffeinated coffee). During the lab sessions they were undergo complete anthropometric measurements and RMR measured (one of the study conditions) using indirect calorimetry. Additionally, respiratory exchange ratio (RER) which is calculated as the ratio between CO2 production (VCO2) and O2 consumption (VO2) (VCO2/VO2), blood pressure and heart rate (HR) response recorded. The importance of this study is that the results will contribute to the scientific basis of weight control and health interventions programs (diet and physical activity) in overweight men.

Conditions

Asymptomatic Conditions

Outcome Measures

Primary Outcomes (1)

• Measurement of resting metabolic expenditure using indirect calorimetry (open flow canopy system)

  Within two weeks (4 sessions, each 30 minutes)

Study Arms (4)

Caffeine

EXPERIMENTAL

Caffeine capsule (200 mg) is taken prior to RMR measurement

Dietary Supplement: Caffeine; Dietary Supplement: Placebo; Other: Coffee; Other: Decaffeinated

Placebo

PLACEBO COMPARATOR

Placebo (starch) capsule is taken prior to RMR measurement

Dietary Supplement: Caffeine; Dietary Supplement: Placebo; Other: Coffee; Other: Decaffeinated

Coffee

EXPERIMENTAL

Black coffee (9 grams) is consumed prior to RMR measurement

Dietary Supplement: Caffeine; Dietary Supplement: Placebo; Other: Coffee; Other: Decaffeinated

Decaffeinated

PLACEBO COMPARATOR

Decaffeinated Black coffee (9 grams) is consumed prior to RMR measurement

Dietary Supplement: Caffeine; Dietary Supplement: Placebo

Interventions

Caffeine DIETARY_SUPPLEMENT

200 mg of caffeine capsule before RMR measurement

Caffeine; Coffee; Decaffeinated; Placebo

Placebo DIETARY_SUPPLEMENT

Placebo capsule (starch) before RMR measurement

Caffeine; Coffee; Decaffeinated; Placebo

Coffee OTHER

9 grams of black coffee in boiling water consumed before RMR measurement

Caffeine; Coffee; Placebo

Decaffeinated OTHER

9 grams of decaffeinated black coffee in boiling water consumed before RMR measurement

Caffeine; Coffee; Placebo

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy men at the age between 20-50 years. 16 normal weight men and 17 obese men.

You may not qualify if:

• Hypertension (above 140/90 mmHg)
• Taking medications for hypertension
• Heart, liver or kidney problems, diabetes, respiratory problems, hypo/hyper thyroidism.
• Smoking
• Men who consume caffeine above 400 mg/day
• Taking medications or dietary supplements that can affect energy expenditure
• Elite athletes (competitive sport)
• Night Eating

Sponsors & Collaborators

• Tel Hai College: lead

Related Publications (6)

• Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K, Jequier E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am J Clin Nutr. 1980 May;33(5):989-97. doi: 10.1093/ajcn/33.5.989.

  PMID: 7369170 BACKGROUND

• Adan A, Prat G, Fabbri M, Sanchez-Turet M. Early effects of caffeinated and decaffeinated coffee on subjective state and gender differences. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Oct 1;32(7):1698-703. doi: 10.1016/j.pnpbp.2008.07.005. Epub 2008 Jul 15.

  PMID: 18675877 BACKGROUND

• Bracco D, Ferrarra JM, Arnaud MJ, Jequier E, Schutz Y. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am J Physiol. 1995 Oct;269(4 Pt 1):E671-8. doi: 10.1152/ajpendo.1995.269.4.E671.

  PMID: 7485480 BACKGROUND

• Jeukendrup AE, Randell R. Fat burners: nutrition supplements that increase fat metabolism. Obes Rev. 2011 Oct;12(10):841-51. doi: 10.1111/j.1467-789X.2011.00908.x.

  PMID: 21951331 BACKGROUND

• Temple JL, Ziegler AM. Gender Differences in Subjective and Physiological Responses to Caffeine and the Role of Steroid Hormones. J Caffeine Res. 2011 Mar;1(1):41-48. doi: 10.1089/jcr.2011.0005.

  PMID: 24761262 BACKGROUND

• Pohanka M. The perspective of caffeine and caffeine derived compounds in therapy. Bratisl Lek Listy. 2015;116(9):520-30. doi: 10.4149/bll_2015_106.

  PMID: 26435014 BACKGROUND

MeSH Terms

Conditions

Asymptomatic Diseases

Interventions

Caffeine; Coffee

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Xanthines; Alkaloids; Heterocyclic Compounds; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Plant Preparations; Biological Products; Complex Mixtures; Beverages; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 21, 2016
• First Posted: April 26, 2016
• Study Start: October 1, 2014
• Primary Completion: August 1, 2015
• Study Completion: April 1, 2016
• Last Updated: April 27, 2016

Record last verified: 2016-04

Data Sharing

• IPD Sharing: Will not share