Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

NCT02741622 | Completed

• 1 other identifier: 2015/2230
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression. The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Conditions

Depressive Disorder; Depressive Disorder, Major

Keywords

Exercise therapy

Outcome Measures

Primary Outcomes (1)

• Change in serum brain derived neurotropic factor (BDNF)

  To measure serum BDNF levels, blood samples will be taken before and after each workout session.

  15 minutes before exercise to 5> minutes after exercise.

Secondary Outcomes (5)

• Change in affective symptoms

  15 minutes before exercise to 15> minutes after exercise.

• Change in state of anxiety.

  15 minutes before exercise and 15> minutes after exercise.

• Change in subjective exercise experience

  15 minutes before exercise to 15> minutes after exercise.

• Maximal oxygen uptake

  Baseline

• Maximal Heart rate

  Baseline

Study Arms (1)

Exercise

EXPERIMENTAL

Acute High aerobic intensity training (HIT) and long slow distance training (LSD)

Behavioral: High aerobic intensity training (HIT); Behavioral: Long slow distance training (LSD)

Interventions

High aerobic intensity training (HIT) BEHAVIORAL

One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)

Exercise

Long slow distance training (LSD) BEHAVIORAL

One training session, long slow distance training (LSD) at 70 % of the HRmax

Exercise

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Moderate or severe depression (ICD10: F32-F33)

You may not qualify if:

• Bipolar disorder.

Sponsors & Collaborators

• St. Olavs Hospital: lead
• Norwegian University of Science and Technology: collaborator

Study Sites (1)

St.Olavs university Hospital, Departement of Østmarka

Trondheim, Norway

Location

MeSH Terms

Conditions

Depressive Disorder; Depressive Disorder, Major

Condition Hierarchy (Ancestors)

Mood Disorders; Mental Disorders

Study Officials

• Pål Sandvik, MD

  St.Olavs University Hospital, Østmarka

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 15, 2016
• First Posted: April 18, 2016
• Study Start: March 1, 2016
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: December 4, 2018

Record last verified: 2018-12

Locations

NO (1)