NCT02738125

Brief Summary

This study assesses the long?term effectiveness of adalimumab in subjects starting a treatment for ulcerative colitis in real life conditions, namely to describe the time to loss of clinical benefit in a time to event approach.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
265

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2016

Longer than P75 for all trials

Geographic Reach
1 country

80 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 11, 2016

Completed
3 days until next milestone

First Posted

Study publicly available on registry

April 14, 2016

Completed
15 days until next milestone

Study Start

First participant enrolled

April 29, 2016

Completed
7.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 15, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2023

Completed
Last Updated

December 31, 2024

Status Verified

December 1, 2024

Enrollment Period

7.6 years

First QC Date

April 11, 2016

Last Update Submit

December 30, 2024

Conditions

Keywords

AdalimumabUlcerative ColitisSOTHISEffectiveness

Outcome Measures

Primary Outcomes (1)

  • Time to loss of clinical benefit

    Loss of clinical benefit will be defined as one of the following: loss of efficacy leading to adalimumab discontinuation or introduction/reinforcement of aminosalicylates, 6-mercaptopurine, or azathioprine, introduction or reinforcement of corticosteroids (any route), UC-related surgery, discontinuation of adalimumab due to adverse event, death.

    Up to Month 120

Secondary Outcomes (3)

  • Change from Baseline (Month 0) in Steroid-free remission

    From Month 0 to Month 120

  • Change from Baseline (Month 0) in Clinical Remission

    From Month 0 to Month 120

  • Change from Baseline (Month 0) in Clinical Response

    From Month 0 to Month 120

Study Arms (1)

Subjects starting/ receiving adalimumab

Subjects starting/ receiving Adalimumab for UC

Eligibility Criteria

Age18 Years - 99 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Subjects starting/ receiving Adalimumab for UC

You may qualify if:

  • Suffering from ulcerative colitis
  • Naïve from Adalimumab
  • Starting a treatment with adalimumab
  • Capable of and willing to grant authorization for use/disclosure of data collected
  • Able to read, understand, and complete patients questionnaires

You may not qualify if:

  • \- None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (80)

Chu de Nice-Hopital L'Archet Ii /Id# 151132

Nice, Alpes-Maritimes, 06200, France

Location

Chu de Nice-Hopital L'Archet Ii /Id# 151181

Nice, Alpes-Maritimes, 06200, France

Location

CHU Clermont-Ferrand /ID# 153527

Clermont, Auvergne-Rhône-Alpes, 63100, France

Location

HCL - Hôpital Lyon Sud /ID# 151146

Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France

Location

HCL - Hôpital Lyon Sud /ID# 151505

Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France

Location

HCL - Hôpital Lyon Sud /ID# 165859

Pierre-Bénite, Auvergne-Rhône-Alpes, 69495, France

Location

Hopital Saint Joseph /ID# 164405

Marseille, Bouches-du-Rhone, 13008, France

Location

APHM - Hopital Nord /ID# 152620

Marseille, Bouches-du-Rhone, 13015, France

Location

CHU NIMES - Hopital Caremeau /ID# 169178

Nîmes, Gard, 30029, France

Location

Cabinet Medical /ID# 155460

BAIE Mahault, Guadeloupe, 97122, France

Location

CHU Toulouse - Hopital Purpan /ID# 167179

Toulouse, Haute-Garonne, 31059, France

Location

CH Annecy Genevois Site Annecy /ID# 151131

Pringy, Haute-Savoie, 74374, France

Location

CHRU Lille - Hopital Claude Huriez /ID# 151514

Lille, Hauts-de-France, 59037, France

Location

CHRU Nancy - Hôpitaux de Brabois /ID# 151147

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54500, France

Location

CHU de SAINT ETIENNE - Hopital Nord /ID# 166807

Saint Priest EN Jarez, Pays de la Loire Region, 42270, France

Location

CH Henri Duffaut /ID# 151383

Avignon, Provence-Alpes-Côte d'Azur Region, 84902, France

Location

CH Henri Duffaut /ID# 151499

Avignon, Provence-Alpes-Côte d'Azur Region, 84902, France

Location

Centre Hospitalier de la Cote /ID# 163714

Bayonne, Pyrenees-Atlantiques, 64100, France

Location

Centre Hosp Intercommunal de Creteil /ID# 152361

Créteil, Val-de-Marne, 94000, France

Location

Centre Medical Alexandre Dumas /Id# 165857

Amiens, 80090, France

Location

Duplicate_Hopital Robert Ballanger /ID# 151382

Aulnay-sous-Bois, 93602, France

Location

Polyclinique du Tondu /ID# 161977

Bordeaux, 33082, France

Location

Centre Endo Nord Isere /ID# 151390

Bourgoin, 38300, France

Location

Geier, Cabinet Medical /ID# 149652

Brest, 29200, France

Location

Hopital de la Cavale Blanche /ID# 152618

Brest, 29200, France

Location

Hopital de la Cavale Blanche /ID# 153608

Brest, 29200, France

Location

Cabinet Medical /ID# 151391

Caen, 14050, France

Location

CHRU Tours - Hopital Trousseau /ID# 163503

Chambray-lès-Tours, 37170, France

Location

Pole Sante Leonard de Vinci /ID# 151384

Chambray-lès-Tours, 37175, France

Location

Ch Chauny /Id# 151149

Chauny, 02303, France

Location

CH du Haut Anjou /ID# 151151

Château-Gontier, 53204, France

Location

Hopital Louis Mourier,Colombes /ID# 152650

Colombe, 92701, France

Location

GHPSO CH Creil /ID# 151117

Creil, 60109, France

Location

Cabinet Medical /ID# 150978

Douarnenez, 29100, France

Location

Cabinet Medical /ID# 150845

Erstein, 67150, France

Location

Centre Gastro Loire /ID# 151387

Gien, 45500, France

Location

Clinique du Palais /ID# 151175

Grasse, 06130, France

Location

CH La Rochelle - Hopital Saint Louis /ID# 151182

La Rochelle, 17019, France

Location

CHU Grenoble - Hopital Michallon /ID# 151508

La Tronche, 38700, France

Location

Duplicate_HOPITAL DUPUYTREN /ID# 157889

Limoges, 87042, France

Location

CH Des Deux Vallees Longumeau /ID# 150977

Longjumeau, 91161, France

Location

HCL - Hopital Edouard Herriot /ID# 151513

Lyon, 69003, France

Location

Centre des consultations spécialisées de la sauvegarde /ID# 151515

Lyon, 69338, France

Location

Centre Medical Les Sources /ID# 151174

Montigny-lès-Cormeilles, 95370, France

Location

AP-HP - Hopital Saint-Louis /ID# 151509

Paris, 75010, France

Location

Hopital Paris Saint-Joseph /ID# 153526

Paris, 75014, France

Location

AP-HP - Hopital Bichat - Claude-Bernard /ID# 151176

Paris, 75018, France

Location

Cabinet Medical /ID# 151118

Paris, 75020, France

Location

Cabinet Medical /ID# 152362

Paris, 75020, France

Location

Duplicate_CHU LYON SUD /ID# 153801

Pierre-Bénite, 69495, France

Location

Cabinet Medical /ID# 151092

Plérin, 22198, France

Location

Cabinet Medical /ID# 151093

Plérin, 22198, France

Location

Cabinet Medical /ID# 151094

Plérin, 22198, France

Location

Cabinet Medical /ID# 151148

Poissy, 78300, France

Location

Cabinet Medical /ID# 151555

Prades-le-Lez, 34730, France

Location

CHRU Pontchaillou /ID# 166806

Rennes, 35033, France

Location

CHU La Réunion - site St Denis - Félix-Guyon /ID# 151556

Saint-Denis, 97405, France

Location

Centre de Consultations /ID# 151128

Saint-Nazaire, 44606, France

Location

Centre de Consultations /ID# 151164

Saint-Nazaire, 44606, France

Location

Centre de Consultations /ID# 155458

Saint-Nazaire, 44606, France

Location

Cabinet Medical /ID# 151559

Saint-Quentin, 02100, France

Location

CHU d'Amiens /ID# 152651

Salouël, 80480, France

Location

Cabinet Medical /ID# 151558

Saverne, 67700, France

Location

Cabinet Medical /ID# 151162

Strasbourg, 67000, France

Location

Centre Medical du Clos de Pacy /ID# 151129

Sucy-en-Brie, 94370, France

Location

Maison de Santé Protestante Bordeaux Bagatelle /ID# 151497

Talence, 33401, France

Location

Cabinet Medical, Dr. Constant, /ID# 151119

Toulon, 83000, France

Location

Clinique Pasteur /ID# 151088

Toulouse, 31076, France

Location

Clinique Pasteur /ID# 155792

Toulouse, 31076, France

Location

Clinique Ambroise Pare /ID# 161978

Toulouse, 31100, France

Location

Cabinet Medical /ID# 170136

Toulouse, 31300, France

Location

Cabinet Medical /ID# 152841

Toulouse, 31400, France

Location

CHU Toulouse - Hopital Rangueil /ID# 157890

Toulouse, 31400, France

Location

Duplicate_Hopital Trousseau /ID# 150168

Tours, 37044, France

Location

Cabinet Medical /ID# 151557

Troyes, 10000, France

Location

GH Mutualiste Les Portes Du Sud /ID# 152374

Vénissieux, 69200, France

Location

GH Mutualiste Les Portes Du Sud /ID# 159231

Vénissieux, 69200, France

Location

Centre Hépato-Biliaire - Hopital Paul-Brousse /ID# 151152

Villejuif, 94800, France

Location

Cabinet Medical /ID# 152617

Voiron, 38500, France

Location

Hopital Beaujon /ID# 151498

Clichy, Île-de-France Region, 92110, France

Location

Related Links

MeSH Terms

Conditions

Colitis, Ulcerative

Condition Hierarchy (Ancestors)

ColitisGastroenteritisGastrointestinal DiseasesDigestive System DiseasesInflammatory Bowel DiseasesColonic DiseasesIntestinal Diseases

Study Officials

  • ABBVIE INC.

    AbbVie

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 11, 2016

First Posted

April 14, 2016

Study Start

April 29, 2016

Primary Completion

December 15, 2023

Study Completion

December 15, 2023

Last Updated

December 31, 2024

Record last verified: 2024-12

Locations