Prospective Evaluation of a Surgical Solution for Breast Cancer-Associated Lymphedema

NCT02734979 | Completed Results DMC FDA Device

• 2 other identifiers: IRB-37161BRS0095
• Study Type: interventional
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate whether addition of the Biobridge scaffold to the standard surgery for vascularized lymph node transfer will improve the outcome of surgical treatment in lymphedema of the upper arm.

Conditions

Lymphedema; Edema

Keywords

lymphedema; edema

Outcome Measures

Primary Outcomes (1)

• Change in Limb Volume

  Lymphoscintigraphy, a measure of limb volume indicative of adequate limb drainage, was conducted on the arm receiving BioBridge implantation (affected arm) and the contralateral (unaffected) arm, before surgery (baseline) and 1 year following surgical implantation of the Biobridge device. The outcome is reported as the median difference in the pre-implantation baseline value and the value 1 year after surgery for each arm.

  1 year

Secondary Outcomes (5)

• Serial Lymphoscintigraphy (LSG)

  1 year

• Bioimpedance Spectroscopy

  1 year

• Caliper Skin-fold Thickness

  1 year

• Cutaneous Punch Biopsy of Skin

  1 year

• Quality of Life for Limb Lymphoedema (LYMQOL)

  1 year

Study Arms (1)

Biobridge and lymph node transfer

EXPERIMENTAL

The investigators will investigate whether addition of the Biobridge scaffold to the standard surgery for vascularized lymph node transfer will improve the outcome of surgical treatment in lymphedema of the upper arm. The investigators will perform lymph scans (lymphoscintigrams) before surgery and one year following surgery to determine the success of the surgery. In addition, the volume of the operated arm will be monitored by repeated measurement with a tape measure. The investigators will also track bioimpedance, a painless technique to detect fluid in the tissues. The investigators will obtain small skin biopsies and blood samples to detect the biological changes that may occur as a result of successful surgery.

Device: Biobridge and lymph node transfer

Interventions

Biobridge and lymph node transfer DEVICE

Biobridge is surgically implanted with conventional vascularized lymph node transfer surgery

Biobridge and lymph node transfer

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The subject must be a breast cancer survivor, at least three years beyond completion of cancer therapy, free of clinical disease, and eligible for surgical intervention.
• Ages 18 to 75 years (inclusive).
• Swelling of 1 limb that is not completely reversed by elevation or compression
• Stage II or greater lymphedema at screening, based on the International Society of Lymphology (ISL) staging system
• Completion of a full course of complete decongestive therapy (CDT), according to ISL guidelines at least 8 weeks prior to screening, including use of compression garments for at least 8 weeks without change in regimen
• Willingness to maintain a stable regimen of self-care, with consistent use of compression garments from screening through the entire study duration (through the safety follow-up visit). Self-bandaging, use of nighttime compression garments, and intermittent pneumatic compression devices are allowed, but the procedures and regimens must remain consistent from screening though the entire study duration.
• Two consecutive measurements of limb volume (LV) in the affected limb taken at least 1 day apart during the screening period must be within 10% of each other. A maximum of 3 measurements can be taken. Affected limb volume ratio \>20% (affected limb compared to unaffected limb); volume measurements will be performed and volume ratio will be calculated at S1 and S2 visit.
• Evidence of abnormal bioimpedance ratio, if feasible based upon unilateral disease: L-Dex \>10 units; bioimpedance performed at S1 and S1
• Willingness and ability to understand and the willingness to sign a written informed consent form document
• Willingness and ability to comply with all study procedures, including measurement of skin thickness using skin calipers.
• Participants must have NED, completed breast cancer therapy 3 years prior to enrollment.
• ECOG 0- 2

You may not qualify if:

• Edema arising from increased capillary filtration will be excluded.
• Inability to safely undergo general anesthesia and/or perioperative care related to vascularized lymph node transfer
• Concurrent participation in a clinical trial of any other investigational drug or therapy, regardless of indication, within 1 month before screening or 5 times the drug's half-life, whichever is longer
• Recent initiation of (≤8 weeks), or intention to initiate, CDPT or maintenance physiotherapy for lymphedema at any time during the duration of the study
• Other medical condition that could lead to acute limb edema, such as (but not limited to) acute venous thrombosis
• Other medical condition that could result in symptoms overlapping those of lymphedema in the affected limb (e.g., pain, swelling, decreased range of motion)
• History of clotting disorder (hypercoagulable state)
• Chronic (persistent) infection in the affected limb
• Any other infection (unrelated to lymphedema) within 1 month prior to screening
• Current evidence of malignancy or any high risk for breast cancer recurrence (Stage III or IV, ER/PR/HER-2 negative (triple negative) cancer , locally advanced disease, inflammatory breast cancer, \> 3 positive axillary lymph nodes, extracapsular nodal extension, invasive micropapillary breast carcinoma, or if performed, patients with a high risk of recurrence based on multi-gene signatures, e.g. BRCA1, BRCA 2, Oncotype DX (high risk recurrence score) or Mammaprint (poor risk signature)
• Currently receiving chemotherapy or radiation therapy
• Life expectancy \< 2 years for any reason
• Pregnancy or nursing
• Substance abuse (such as alcohol or drug abuse) within 6 months prior to screening
• Significant or chronic renal insufficiency (defined as serum creatinine \> 2.5 mg/dL or an estimated glomerular filtration rate \[eGFR\] \< 30 mL/min at screening) or requires dialytic support

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Stanford University

Stanford, California, 94305, United States

Location

MeSH Terms

Conditions

Lymphedema; Edema

Condition Hierarchy (Ancestors)

Lymphatic Diseases; Hemic and Lymphatic Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr. Stanley G Rockson, Allan and Tina Neill Professor of Lymphatic Research and Medicine
• Organization: Stanford University

rockson@stanford.edu

650-725-7571

Study Officials

• Stanley G Rockson, MD

  Stanford University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Allan and Tina Neill Professor of Lymphatic Research and Medicine

Study Record Dates

• First Submitted: April 5, 2016
• First Posted: April 12, 2016
• Study Start: July 20, 2016
• Primary Completion: July 7, 2018
• Study Completion: October 29, 2020
• Last Updated: October 27, 2022
• Results First Posted: July 15, 2021

Record last verified: 2022-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)