Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
1 other identifier
observational
103
1 country
5
Brief Summary
Asynchrony during mechanical ventilation has been poorly described in patients suffering from acute respiratory distress syndrome. The purpose of this study is to describe the frequency of asynchronies (ineffective efforts and double triggering) in these group and evaluate potential risk factors and prognosis implications.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2016
Typical duration for all trials
5 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 19, 2016
CompletedFirst Posted
Study publicly available on registry
April 8, 2016
CompletedStudy Start
First participant enrolled
May 25, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 22, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2019
CompletedJanuary 6, 2020
January 1, 2020
2.5 years
March 19, 2016
January 2, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Asynchrony rate
Asynchronies per minutes of mechanical ventilation
30 minutes
Secondary Outcomes (3)
Length of mechanical ventilation
From the date of intubation to the date of complete weaning from mechanical ventilation or death which ever comes first, up to 90 days
ICU mortality
From the date of admission to the date of discharge from the ICU, up to 90 days
Hospital mortality
From the date of admission to the date of discharge from the ICU, up to 90 days
Eligibility Criteria
Patients with diagnosis of acute respiratory distress syndrome and mechanical ventilation for less than 72 hours
You may qualify if:
- Acute Respiratory Distress Syndrome according to Berlin definition
You may not qualify if:
- Known severe neuromuscular disease
- Continuous neuromuscular blocking agents infusion
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (5)
Complejo Medico Churruca Visca
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina
Sanatorio Anchorena
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina
Sanatorio La Trinidad Mitre
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina
CEMIC (Centro de Educación Médica e Investigaciones Clínicas)
CABA, 1431, Argentina
Related Publications (1)
Rodriguez PO, Tiribelli N, Fredes S, Gogniat E, Plotnikow G, Fernandez Ceballos I, Pratto R, Raimondi A, Guaymas M, Ilutovich S, San Roman E, Madorno M, Maskin P, Brochard L, Setten M; Grupo Argentino de Estudio de Asincronias en la Ventilacion Mecanica Study Group. Prevalence of Reverse Triggering in Early ARDS: Results From a Multicenter Observational Study. Chest. 2021 Jan;159(1):186-195. doi: 10.1016/j.chest.2020.08.018. Epub 2020 Aug 14.
PMID: 32805238DERIVED
Biospecimen
plasma
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Pablo O Rodriguez, MD
Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assosiated Professor
Study Record Dates
First Submitted
March 19, 2016
First Posted
April 8, 2016
Study Start
May 25, 2016
Primary Completion
November 22, 2018
Study Completion
February 1, 2019
Last Updated
January 6, 2020
Record last verified: 2020-01
Data Sharing
- IPD Sharing
- Will not share