Quantitative Myocardial Perfusion Reserve by Cardiovascular Magnetic Resonance
1 other identifier
observational
66
1 country
1
Brief Summary
The purpose of this study is to validate a full-automated post-processing software for quantitative perfusion of the myocardium with magnetic resonance imaging.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Mar 2016
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2016
CompletedFirst Submitted
Initial submission to the registry
March 16, 2016
CompletedFirst Posted
Study publicly available on registry
March 30, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2023
CompletedJune 8, 2022
June 1, 2022
2 years
March 16, 2016
June 7, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Accuracy of global myocardial first pass perfusion in mL/min/g measured in automatic post-processed color maps compared with myocardial blood volume measured in the coronary sinus (mL/min) divided by the total left ventricle mass (g)
Through study completion, an average of 9 months
Study Arms (1)
Healthy volunteers
Healthy subjects with normal 12-lead electrocardiogram at rest.
Interventions
Eligibility Criteria
Prospectively enroll 80 adult healthy volunteers (40 females and 40 males).
You may qualify if:
- healthy individuals with normal 12-lead electrocardiogram at rest.
You may not qualify if:
- systolic blood pressure below 90 mmHg;
- bradycardia (\< 45 heart beats/minute);
- intake of caffeine or caffeine-containing drink/medicine 24 hours prior to the examination;
- impaired renal function assessed by venous blood sample.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Molecular Medicine and Surgery, Karolinska Institutet
Stockholm, 171 76, Sweden
Related Publications (1)
Nickander J, Themudo R, Thalen S, Sigfridsson A, Xue H, Kellman P, Ugander M. The relative contributions of myocardial perfusion, blood volume and extracellular volume to native T1 and native T2 at rest and during adenosine stress in normal physiology. J Cardiovasc Magn Reson. 2019 Nov 25;21(1):73. doi: 10.1186/s12968-019-0585-9.
PMID: 31767018DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Martin Ugander, MD, PhD
Department of Molecular Medicine and Surgery, Karolinska Institutet
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, PhD
Study Record Dates
First Submitted
March 16, 2016
First Posted
March 30, 2016
Study Start
March 1, 2016
Primary Completion
March 1, 2018
Study Completion
December 1, 2023
Last Updated
June 8, 2022
Record last verified: 2022-06
Data Sharing
- IPD Sharing
- Will not share