Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up

NCT02717559 | Completed

• 1 other identifier: 160049
• Study Type: observational
• Target: 225
• Locations: 0 countries
• Sites: N/A

Brief Summary

In this study the investigators will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.

Conditions

Musculoskeletal Diseases; Osteoarthritis; Arthritis; Joint Diseases; Rheumatic Diseases

Keywords

Anterior cruciate ligament / injuries; Anterior cruciate ligament / surgery; knee injuries / surgery; outcomes research; prospective studies; osteoarthritis

Outcome Measures

Primary Outcomes (2)

• Joint space width measured on weight-bearing radiographs

  10 years after ACL reconstruction surgery

• Pain subscale of the Knee Injury and Osteoarthritis Score (KOOS).

  10 years after ACL reconstruction surgery

Secondary Outcomes (1)

• Knee related quality of life subscale of the Knee Injury and Osteoarthritis Score (KOOS)

  10 years after ACL reconstruction surgery

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants enrolled in the Multicenter Orthopaedic Outcomes Network cohort by one of study site surgeons and meeting eligibility criteria

You may qualify if:

• Had primary unilateral ACL reconstruction performed by Dr. Kurt Spindler (Vanderbilt University), Dr. Christopher Kaeding (The Ohio State University), Dr. Rick Parker (Cleveland Clinic), Dr. Jack Andrish (Cleveland Clinic), Dr. Rick Wright (Washington University, St. Louis), or Dr. Matthew Matava (Washington University, St. Louis).
• Participated in the 2 yr onsite visit

You may not qualify if:

• Unable to be consented
• Unable to participate for health reasons
• History of intra-articular knee infection
• History of total knee arthroplasty on either knee

Sponsors & Collaborators

• Washington University School of Medicine: collaborator
• Vanderbilt University Medical Center: lead
• The Cleveland Clinic: collaborator
• Ohio State University: collaborator

Related Publications (1)

• MOON Group; Everhart JS, Jones MH, Yalcin S, Reinke EK, Huston LJ, Andrish JT, Cox CL, Flanigan DC, Kaeding CC, Magnussen RA, Obuchowski N, Parker RD, Pedroza AD, Sanders RA, Winalski CS, Spindler KP. The Clinical Radiographic Incidence of Posttraumatic Osteoarthritis 10 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON Nested Cohort. Am J Sports Med. 2021 Apr;49(5):1251-1261. doi: 10.1177/0363546521995182.

  PMID: 33793363 DERIVED

MeSH Terms

Conditions

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Anterior Cruciate Ligament Injuries; Knee Injuries

Condition Hierarchy (Ancestors)

Connective Tissue Diseases; Skin and Connective Tissue Diseases; Leg Injuries; Wounds and Injuries

Study Officials

• Kurt P Spindler, MD

  Vanderbilt University / The Cleveland Clinic Foundation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Adjoint Professor

Study Record Dates

• First Submitted: March 17, 2016
• First Posted: March 23, 2016
• Study Start: March 1, 2016
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: January 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share