NCT02702687

Brief Summary

This randomized controlled trial will include Latino and Black adolescents with asthma ages 10-17 years old and their caregivers. Participants will be recruited from clinics in the Bronx, New York. The primary aims are to examine the efficacy of peak expiratory flow (PEF) prediction with feedback versus control feedback on 1) under-perception of asthma symptoms 2) controller medication adherence and 3) asthma control and emergency health care use. These aims will be examined across a 1-year follow-up. An exploratory aim examines the hypothesized pathway that the PEF intervention reduces under-perception of symptoms, shifts illness representations toward the professional model and increases adolescents' and parents' asthma management self-efficacy, resulting in greater medication adherence and improved asthma control.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
363

participants targeted

Target at P75+ for not_applicable asthma

Timeline
Completed

Started May 2016

Longer than P75 for not_applicable asthma

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 25, 2016

Completed
13 days until next milestone

First Posted

Study publicly available on registry

March 9, 2016

Completed
2 months until next milestone

Study Start

First participant enrolled

May 1, 2016

Completed
6.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 28, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 28, 2022

Completed
Last Updated

February 6, 2023

Status Verified

February 1, 2023

Enrollment Period

6.2 years

First QC Date

February 25, 2016

Last Update Submit

February 3, 2023

Conditions

Keywords

AsthmaChildhood AsthmaBronchial DiseasesImmune System DiseasesLung DiseasesLung Diseases, ObstructiveRespiratory Tract DiseasesPeak Flow MeterSymptom PerceptionIllness Representation

Outcome Measures

Primary Outcomes (1)

  • Asthma Symptom Perception with Asthma Monitor (AM2) as percentage of guesses in the Under-Perception zone

    The percentage of times a child under-perceives the severity of asthma symptoms

    Change from Pre-intervention to 12-month-follow-up (15 months)

Secondary Outcomes (6)

  • Asthma Illness Representation Scale (AIRS)

    Change from Pre-intervention to 12-month-follow-up (15 months)

  • Asthma Management Self-Efficacy (ASE) scale: Parent and child versions

    Change from Pre-intervention to 12-month-follow-up (15 months)

  • Pediatric Asthma Quality of Life Questionnaire (PAQLQ)

    Change from Pre-intervention to 12-month-follow-up (15 months)

  • Medication Adherence - percentage of total doses taken per day/prescribed per day

    Change from Pre-intervention to 12-month-follow-up (15 months)

  • Health Care Use - Electronic Medical Record (EMR) review of asthma-related Emergency Department visits and hospitalizations

    Change from Pre-intervention to 12-month-follow-up (15 months)

  • +1 more secondary outcomes

Study Arms (2)

PEF Feedback

EXPERIMENTAL

This group will have 9 visits across 15 months.

Behavioral: PEF Feedback

Control Feedback

ACTIVE COMPARATOR

This group will have 9 visits across 15 months.

Behavioral: Control Feedback

Interventions

PEF FeedbackBEHAVIORAL

Intervention group will receive PEF feedback and verbal feedback sessions across 3 feedback visits and asthma education.

PEF Feedback

Control feedback group will receive feedback consisting of standardized messages and have 3 control feedback visits and asthma education.

Control Feedback

Eligibility Criteria

Age10 Years - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • years of age
  • Diagnosis of asthma (in medical record)
  • Report of breathing problems within the past 12 months
  • Prescribed a controller medication for asthma
  • At least one parent self-identifies as Latino or Black
  • The participating parent has primary or at least equal responsibility for the adolescent

You may not qualify if:

  • Cognitive learning disability (parent report)
  • No prescription for asthma controller medication
  • Inability to perform acceptable PEF blows
  • Race/ethnicity other than Latino or Black
  • Other significant pulmonary conditions (cystic fibrosis)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Jacobi Medical Center

The Bronx, New York, 10461, United States

Location

Montefiore Medical Center

The Bronx, New York, 10461, United States

Location

Related Publications (1)

  • Feldman JM, Rastogi D, Warman K, Serebrisky D, Arcoleo K. Peak Flow Feedback Intervention Improves Underperception of Airflow Limitation in Pediatric Asthma: A Randomized Clinical Trial. Ann Am Thorac Soc. 2025 Mar;22(3):403-415. doi: 10.1513/AnnalsATS.202406-637OC.

MeSH Terms

Conditions

AsthmaBronchial DiseasesImmune System DiseasesLung DiseasesLung Diseases, ObstructiveRespiratory Tract Diseases

Condition Hierarchy (Ancestors)

Respiratory HypersensitivityHypersensitivity, ImmediateHypersensitivity

Study Officials

  • Jonathan Feldman, PhD

    Albert Einstein College of Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 25, 2016

First Posted

March 9, 2016

Study Start

May 1, 2016

Primary Completion

July 28, 2022

Study Completion

July 28, 2022

Last Updated

February 6, 2023

Record last verified: 2023-02

Data Sharing

IPD Sharing
Will not share

Locations