NCT02702440|Unknown
Meta-analyses of Liquid Versus Solid Calories and Body Weight
Effect of Liquid Versus Solid Calories on Body Weight: a Systematic Review and Meta-analysis of Controlled Feeding Trials
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Effect of Liquid Versus Solid Calories on Body Weight: a Systematic Review and Meta-analysis of Controlled Feeding Trials
Sponsor study identifier
observational
1
1 country
1
Study Start
May 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Consumption of sugar-sweetened beverages (SSBs) has been linked to rising rates of overweight and obesity. The most prominent mechanism to explain the link between SSBs and obesity is that liquid calories are not perceived by the body; thereby, promoting less satiety, less energy compensation and more weight gain than does the same energy consumed in solid form. This view is supported by pooled analyses of acute preload trials that have primarily measured food intake as the outcome. Though failure of short-term compensation has been observed with liquid calories, results from these acute preload trials should not be extrapolated to infer that liquid energy sources lead to weight gain over the long-term. To date, it is unclear whether liquid calories have differential effects than solid calories on body weight gain over the longer term. To increase clarity in this issue, the investigators propose to conduct a systematic review and meta-analysis from long-term controlled feeding trials to distinguish the contribution of liquid calories from solid calories on body weight over the long-term. The findings generated by this analysis will improve the health of consumers through informing evidence-based guidelines and improving health outcomes by educating healthcare providers and patients, stimulating industry innovation, and guiding future research design.
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December 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 2015
Date type not reportedThis date has not been verified as actual or estimated.
March 2, 2016
Actual (reported)March 8, 2016
Actual (reported)September 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Body weight
Up to 20 years
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All individuals, both children and adults, regardless of health status.
The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital
Toronto, Ontario, M5C 2T2, Canada
Kaiser KA, Shikany JM, Keating KD, Allison DB. Will reducing sugar-sweetened beverage consumption reduce obesity? Evidence supporting conjecture is strong, but evidence when testing effect is weak. Obes Rev. 2013 Aug;14(8):620-33. doi: 10.1111/obr.12048. Epub 2013 Jun 7.
Almiron-Roig E, Palla L, Guest K, Ricchiuti C, Vint N, Jebb SA, Drewnowski A. Factors that determine energy compensation: a systematic review of preload studies. Nutr Rev. 2013 Jul;71(7):458-73. doi: 10.1111/nure.12048. Epub 2013 Jun 10.
John L Sievenpiper, MD, PhD, FRCPC
University of Toronto
First Submitted
March 2, 2016
First Posted
March 8, 2016
Study Start
May 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2016
Estimated (date passed)Meta-analyses of the Effect of Tree Nuts on Glycemic Control and Features of the Metabolic Syndrome
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Allison DB. Liquid calories, energy compensation and weight: what we know and what we still need to learn. Br J Nutr. 2014 Feb;111(3):384-6. doi: 10.1017/S0007114513003309. Epub 2013 Oct 29. No abstract available.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
May 17, 2016
Record last verified: 2016-05
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