Pomegranate Improve Biological Recovery Kinetics in Elite Weightlifter

NCT02697903 | Completed DMC

• 1 other identifier: 16-2015
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

From the recent scientific literature in the field of biological response to physical exercise, a significant increase in muscle damage, soreness and inflammation were registered immediately and even 48 after resistance exercise. In the other hand, from the recent scientific literature in the field of nutrition it is well established that Pomegranate juice is a potent antioxidant that can help prevent or treat various disease risk factors. However, only few studies associated the effect of the pomegranate with the physical exercise. To the authors' knowledge, there are no studies investigated the acute and delayed effect of pomegranate supplementation in performance and muscle recovery after exercises involved muscle of whole body. Therefore, the aim of the present study was to investigate the effect of natural Pomegranate juice supplementation on the acute and delayed response of muscle soreness and biochemical parameters following weightlifting training session

Conditions

Healthy

Keywords

Creatine kinase supplementation; C-reactive protein; resistance training; Pomegranate supplementation; pomegranate juice; muscle damage response

Outcome Measures

Primary Outcomes (5)

• Change in physical performance from using Placebo to using Pomegranate juice

  The performance in each session was measured by the total volume lifted in the two Olympic movements (volume lifted (kg) in snatch added volume lifted (kg) in clean and Jerk: only the right lifts are taken into consideration) and by the maximal power lifted amounts in both Olympic movement (i.e., the maximal load lifted (kg) in the power snatch added to the maximal load lifted (kg) in the power clean and Jerk)

  3min after Placebo and Pomegranate training sessions

• Change in Acute Hematological responses from using Placebo to using Pomegranate juice

  Haematological parameters (i.e., white blood cells (WBC), neutrophils (NEU), red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT)and platelets (PLT) were generally performed within 3 h of blood sampling in a multichannel automated blood cell analyser Beckman Coulter Gen system-2 (Coulter T540)

  3min after Placebo and Pomegranate training sessions

• Change in Acute Biochemical responses from using Placebo to using Pomegranate juice

  Glycemia (GLY), Creatinine (CRE), muscle damage markers (Creatinine kinase (CK), Alkaline phosphate (PAL), Gammaglutamyl (GGT), Lactate dehydrogenase (LDH)) and c-reactive protein (CRP) were determined spectrophotometrically using Abott Architect Ci 4100

  3min after Placebo and Pomegranate training sessions

• Change in Delayed Hematological responses from using Placebo to using Pomegranate juice

  Haematological parameters (i.e., white blood cells (WBC), neutrophils (NEU), red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT)and platelets (PLT) were generally performed within 3 h of blood sampling in a multichannel automated blood cell analyser Beckman Coulter Gen system-2 (Coulter T540)

  48h after Placebo and Pomegranate training sessions

• Change in Delayed Biochemical responses from using Placebo to using Pomegranate juice

  Glycemia (GLY), Creatinine (CRE), muscle damage markers (Creatinine kinase (CK), Alkaline phosphate (PAL), Gammaglutamyl (GGT), Lactate dehydrogenase (LDH)) and c-reactive protein (CRP) were determined spectrophotometrically using Abott Architect Ci 4100

  48h after Placebo and Pomegranate training sessions

Secondary Outcomes (7)

• Change in the acute fatigue perception (RPE values) from Placebo to Pomegranate supplementation

  3min after Placebo and Pomegranate training sessions

• Change in the delayed muscle soreness (DOMS values) from Placebo to Pomegranate supplementation

  48 after Placebo and Pomegranate training sessions

• Change in the acute oral temperature response from Placebo to Pomegranate supplementation

  3min after Placebo and Pomegranate training sessions

• Change in the acute Heart rate ( HR) response from Placebo to Pomegranate supplementation

  3min after Placebo and Pomegranate training sessions

• Change in the acute systolic arterial pressure (SAP) response from Placebo to Pomegranate supplementation

  3min after Placebo and Pomegranate training sessions

Study Arms (2)

9 elite weightlifters

EXPERIMENTAL

age: 21 ± 0.5 years, body mass: 80 ± 20 kg, height 175 ± 8.1 cm (mean ± SD). They received "Natural Pomegranate Juice" supplementation during and 48h following the first weightlifting training session.

Dietary Supplement: Natural Pomegranate Juice

9elite weightlifters

PLACEBO COMPARATOR

age: 21 ± 0.5 years, body mass: 80 ± 20 kg, height 175 ± 8.1 cm (mean ± SD). They received "Placebo Juice" supplementation during and 48h following the second weightlifting training session.

Dietary Supplement: Placebo Juice

Interventions

Natural Pomegranate Juice DIETARY_SUPPLEMENT

Supplements (1500ml) of pomegrenate juice (POMj) were taken three times daily in the 48h which proceed the first tested training sessions (i.e. 250ml × 6 times with 8-h intervals between it). Moreover, during this tested sessions, subject consumed an additional 500ml of POMj. Arm-specific: Experimental: 9 elite weightlifter

9 elite weightlifters

Placebo Juice DIETARY_SUPPLEMENT

Supplements (1500ml) of Placebo juice (PLA) were taken three times daily in the 48h which proceed the second tested training sessions (i.e. 250ml × 6 times with 8-h intervals between it). Moreover, during this tested sessions, subject consumed an additional 500ml of POMj. Arm-specific: Placebo Comparator: 9 elite weightlifter

9elite weightlifters

Eligibility Criteria

• Age: 20 Years - 24 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• trained at least five sessions per week with 90 to 120 min per session
• had an experience of more than 3 years in Olympic weightlifting

You may not qualify if:

• use any antioxidant (e.g., vitamin E, A, C etc..) or anti-inflammatory during the experimentation period and one month before
• had injuries during the experimentation period and one month before

Sponsors & Collaborators

• The Higher Institute of Sport and Physical Education of Sfax: lead

Study Sites (1)

Achraf

Sfax, 3000, Tunisia

Location

Related Publications (3)

• Ammar A, Trabelsi K, Bailey SJ, Turki M, Bragazzi NL, Boukhris O, El Abed K, Bouaziz M, Ayadi F, Driss T, Souissi N, Chtourou H, Hokelmann A. Effects of natural polyphenol-rich pomegranate juice supplementation on plasma ion and lipid profiles following resistance exercise: a placebo-controlled trial. Nutr Metab (Lond). 2020 Apr 16;17:31. doi: 10.1186/s12986-020-00451-1. eCollection 2020.

  PMID: 32322289 DERIVED

• Ammar A, MounaTurki, Trabelsi K, Bragazzi NL, Boukhris O, Bouaziz M, Ayadi F, El Abed K, Driss T, Souissi N, Chtourou H, Bailey SJ, Hoekelmann A. Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: a double-blind, placebo-controlled trial. J Int Soc Sports Nutr. 2020 Mar 6;17(1):15. doi: 10.1186/s12970-020-00345-w.

  PMID: 32143716 DERIVED

• Ammar A, Turki M, Chtourou H, Hammouda O, Trabelsi K, Kallel C, Abdelkarim O, Hoekelmann A, Bouaziz M, Ayadi F, Driss T, Souissi N. Pomegranate Supplementation Accelerates Recovery of Muscle Damage and Soreness and Inflammatory Markers after a Weightlifting Training Session. PLoS One. 2016 Oct 20;11(10):e0160305. doi: 10.1371/journal.pone.0160305. eCollection 2016.

  PMID: 27764091 DERIVED

Study Officials

• Achraf Ammar, Dr

  Institute of sport and physical education of Sfax, Tunisia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: February 24, 2016
• First Posted: March 3, 2016
• Study Start: January 1, 2015
• Primary Completion: February 1, 2015
• Study Completion: February 1, 2015
• Last Updated: March 3, 2016

Record last verified: 2016-03

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)