NCT02506283

Brief Summary

This study investigates the effects of cooling on the recovery and performance characteristic in young healthy subjects. The study is divided in two projects: Project A: investigates the effects of 20 min. post-exercise cooling on vertical jump performance and delayed onset muscle soreness and rated perceived exertion. Project B: investigates the effects of 20 min. pre-exercise cooling on maximal voluntary contraction of the right M. quadriceps femoris and delayed onset muscle soreness and rated perceived exertion.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
22

participants targeted

Target at P25-P50 for not_applicable healthy

Timeline
Completed

Started May 2015

Longer than P75 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2015

Completed
26 days until next milestone

First Submitted

Initial submission to the registry

May 27, 2015

Completed
2 months until next milestone

First Posted

Study publicly available on registry

July 23, 2015

Completed
3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2018

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2019

Completed
6.5 years until next milestone

Results Posted

Study results publicly available

October 20, 2025

Completed
Last Updated

October 20, 2025

Status Verified

September 1, 2025

Enrollment Period

3.5 years

First QC Date

May 27, 2015

Results QC Date

September 30, 2025

Last Update Submit

September 30, 2025

Conditions

Keywords

cryotherapyrecoveryathletic performancemaximum voluntary contractionrated perceived exertiondelayed onset muscle sorenessjump performance

Outcome Measures

Primary Outcomes (4)

  • Delayed-onset Muscle Soreness (DOMS)

    The subjective recovery characteristics "Delayed-onset muscle soreness (DOMS)" was rated on a 0-10 cm visual analog scale. DOMS was assessed in a squat position (90° knee angle, with brief holding of maximum 3 seconds) ranging from zero (no soreness) to ten (severe soreness). Higher values mean mean more DOMS and therefore less recovery.

    72 hours

  • Ratings of Perceived Exertion (RPE)

    The subjective recovery characteristics " Ratings of perceived exertion (RPE)" was rated on a 6-20 Borg scale (from 6 = "no exertion at all" to 20 = "Maximal exertion") in a standing position. The higher value means more exertion and therefore less recovery.

    72 hours

  • Vertical Jump Performance (VJP)

    Vertical jump performance (VJP) was assessed performing three maximal counter mouvemet jumps (CMJs) with a 30-second pause between the three jumps on the Just Jump system (Probotics Inc, Huntsville, AL, USA). The highest jump was recorded.

    72 hours

  • Peak Power Output (PPO)

    Peak power output (PPO) was assessed performing three maximal counter movement jumps (CMJs) on the Just Jump system (Probotics Inc, Huntsville, AL, USA) with a 30-second pause between the three jumps. PPO (presented in watts) was calculated.

    72 hours

Study Arms (2)

cooling intervention

EXPERIMENTAL

subjects in this study receive a single pre-exercise (3x MVC) or post-exercise intervention (3x 30 counter movement jumps), consisting of an external cooling application (Zamar Therapy CT clinic) applied to both thighs. Both interventions have a duration of 20 minutes and a temperature of 8°C

Device: Zamar Therapy CT clinic

thermoneutral intervention

SHAM COMPARATOR

subjects in the control group receive a single pre-exercise (3x MVC) or post-exercise (3x 30 counter movement jumps) sham intervention, consisting of a 20 minute external thermoneutral application (Zamar Therapy CT clinic) applied to both thighs. Both sham interventions have a duration of 20 minutes and a temperature of 32°C.

Device: Zamar Therapy CT clinic

Interventions

Zamar Therapy is a certified medical product (directive 93/42/EEC and ISO 134 85:2012) (www.zamarmedical.com)

cooling interventionthermoneutral intervention

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • only healthy young subjects 18-30 years
  • no musculoskeletal surgery in trunk and lower extremities
  • injury history in trunk and lower extremity for more than one year
  • subjects taking anticonceptive medication are allowed to participate

You may not qualify if:

  • actual injuries or injuries for less than one year in trunk and /or lower extremities
  • injury history in trunk and lower extremity for more than one year with complaints
  • anxiety of cooling
  • subjects on medication
  • pace maker
  • cardiovascular disease
  • pregnancy
  • skeletal problems
  • appendectomy for less than two years
  • Morbus Raynaud syndrome

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Applied Sciences and Arts of Southern Switzerland SUPSI

Landquart, Kanton Graubünden, 7302, Switzerland

Location

Related Publications (8)

  • Bleakley C, McDonough S, Gardner E, Baxter GD, Hopkins JT, Davison GW. Cold-water immersion (cryotherapy) for preventing and treating muscle soreness after exercise. Cochrane Database Syst Rev. 2012 Feb 15;2012(2):CD008262. doi: 10.1002/14651858.CD008262.pub2.

    PMID: 22336838BACKGROUND
  • Ross ML, Garvican LA, Jeacocke NA, Laursen PB, Abbiss CR, Martin DT, Burke LM. Novel precooling strategy enhances time trial cycling in the heat. Med Sci Sports Exerc. 2011 Jan;43(1):123-33. doi: 10.1249/MSS.0b013e3181e93210.

    PMID: 20508537BACKGROUND
  • Ascensao A, Leite M, Rebelo AN, Magalhaes S, Magalhaes J. Effects of cold water immersion on the recovery of physical performance and muscle damage following a one-off soccer match. J Sports Sci. 2011 Feb;29(3):217-25. doi: 10.1080/02640414.2010.526132.

  • Banfi G, Lombardi G, Colombini A, Melegati G. Whole-body cryotherapy in athletes. Sports Med. 2010 Jun 1;40(6):509-17. doi: 10.2165/11531940-000000000-00000.

  • Barnett A. Using recovery modalities between training sessions in elite athletes: does it help? Sports Med. 2006;36(9):781-96. doi: 10.2165/00007256-200636090-00005.

  • Pointon M, Duffield R, Cannon J, Marino FE. Cold application for neuromuscular recovery following intense lower-body exercise. Eur J Appl Physiol. 2011 Dec;111(12):2977-86. doi: 10.1007/s00421-011-1924-1. Epub 2011 Mar 29.

  • Wegmann M, Faude O, Poppendieck W, Hecksteden A, Frohlich M, Meyer T. Pre-cooling and sports performance: a meta-analytical review. Sports Med. 2012 Jul 1;42(7):545-64. doi: 10.2165/11630550-000000000-00000.

  • White GE, Wells GD. Cold-water immersion and other forms of cryotherapy: physiological changes potentially affecting recovery from high-intensity exercise. Extrem Physiol Med. 2013 Sep 1;2(1):26. doi: 10.1186/2046-7648-2-26.

Related Links

Results Point of Contact

Title
Dr. Erich Hohenauer
Organization
University of Applied Sciences and Arts of Southern Switzerland (SUPSI)

Study Officials

  • Ron Clijsen, PhD

    University of Applied Sciences and Arts of Southern Switzerland SUPSI

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 27, 2015

First Posted

July 23, 2015

Study Start

May 1, 2015

Primary Completion

November 1, 2018

Study Completion

May 1, 2019

Last Updated

October 20, 2025

Results First Posted

October 20, 2025

Record last verified: 2025-09

Locations