Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients With Low Grade Gliomas

NCT02686229 | Recruiting DMC

• 1 other identifier: LoG-Glio
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The LoG-Glio-Registry is based on a network of german hospitals gathering radiological, clinical, epidemiological and molecular data on all patients diagnosed with a low grade glioma.

Conditions

Glioma

Keywords

Low grade glioma, registry, neurosurgery, brain tumor

Outcome Measures

Primary Outcomes (2)

• Progression-free survival (PFS)

  5yrs

• Overall survival (OS)

  15yrs

Secondary Outcomes (2)

• Extent of tumor resection

  3yrs

• Quality of life (QoL) assessed by the EORTC QLQ C-30/BN-20. (European Organisation for Research and Treatment of Cancer Quality of Life Questionaire C-30

  5yrs

Interventions

no interventions OTHER

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All adult patients with radiological suspected diagnosis of a low grade glioma

You may qualify if:

• Patients with radiological suspected diagnosis of a low grade glioma
• Age ≥ 18 years. There is no upper age limit.

You may not qualify if:

• Severe neurological or psychiatric disorder interfering with ability to give an informed consent
• No consent for registration, storage and processing of the individual disease characteristics and course as well as information of the family physician about study participation
• No consent for bio-banking of patient's biological specimens and performance of analyses on stored material.

Sponsors & Collaborators

• University of Ulm: lead
• Charite University, Berlin, Germany: collaborator

Study Sites (1)

University of Ulm

Ulm, Germany

RECRUITING

Related Publications (1)

• Pala A, Nadji-Ohl M, Faust K, Ruckriegel S, Roder C, von der Brelie C, Forster MT, Lobel F, Schommer S, Lohr M, Renovanz M, Grubel N, Rothenbacher D, Konig R, Engelke J, Schmitz B, Wirtz CR, Ringel F, Senft C, Rohde V, Tatagiba M, Ernestus RI, Vajkoczy P, Ganslandt O, Nagel G, Coburger J. Multicentric Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients with Low-Grade Gliomas: The LoG-Glio Project. J Neurol Surg A Cent Eur Neurosurg. 2020 Jan;81(1):48-57. doi: 10.1055/s-0039-1693650. Epub 2019 Sep 24.

  PMID: 31550737 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood and tumor samples

MeSH Terms

Conditions

Glioma; Brain Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Central Study Contacts

Jan Coburge, MD

CONTACT

082219628858; jan.coburger@uni-ulm.de

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Study Record Dates

• First Submitted: February 4, 2016
• First Posted: February 19, 2016
• Study Start: November 15, 2015
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 1, 2036
• Last Updated: May 11, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)