Comparing the Ketogenic Effect of Coconut Oil and Different MCTs
MCT-Coco
1 other identifier
interventional
10
1 country
1
Brief Summary
The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2015
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2015
CompletedFirst Submitted
Initial submission to the registry
February 1, 2016
CompletedFirst Posted
Study publicly available on registry
February 10, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2017
CompletedResults Posted
Study results publicly available
April 6, 2020
CompletedApril 6, 2020
March 1, 2020
1.5 years
February 1, 2016
February 11, 2019
March 23, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Plasma Ketone Concentrations
Total ketones = Plasma acetoacetate (µmol/L) + beta-hydroxybutyrate (µmol/L) measured over a 8 hour period (i.e. daily mean). Samples are taken every 30 minutes on a 8 hours period. The mean is reported here.
8 hours
Secondary Outcomes (1)
Plasma Acetoacetate/Beta-hydroxybutyrate Ratio
8 hours
Study Arms (1)
Supplementation
EXPERIMENTALProtocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT \[tricaprylin/tricaprin\]; coconut oil + MCT \[50:50\]; Coconut oil + tricaprylin \[50:50\]) taken twice, once at breakfast and once at mid-day.
Interventions
10 g of coconut oil + 10 g of MCT (60 of C8 + 40 of C10)
10 g coconut oil + 10 g tricaprylin
Eligibility Criteria
You may qualify if:
- Healthy adult over 18 y old.
You may not qualify if:
- Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics);
- Smoking
- Clinically-significant gastro-intestinal disease/conditions.
- Clinically-significant liver disease/dysfunction.
- Clinically-significant cardiac disease/conditions.
- Clinically-significant abnormal coagulation.
- Taking a medication that could affect lipid and glucose metabolism
- Hypertension
- Pregnancy or breastfeeding
- Exercising more than 3 times a week
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)
Sherbrooke, Quebec, J1H4C4, Canada
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Pr. Stephen Cunnane
- Organization
- Université de Sherbrooke
Study Officials
- PRINCIPAL INVESTIGATOR
Stephen Cunnane, PhD
CSSS-IUGS - CIUSSS de L'Estrie - CHUS - Université de Sherbrooke
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 1, 2016
First Posted
February 10, 2016
Study Start
June 1, 2015
Primary Completion
December 1, 2016
Study Completion
March 1, 2017
Last Updated
April 6, 2020
Results First Posted
April 6, 2020
Record last verified: 2020-03