NCT02669602

Brief Summary

Dynamic prospective cohort of Spanish university graduates. The main objective is to evaluate the associations between nutrition and lifestyle and chronic diseases.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
22,500

participants targeted

Target at P75+ for all trials

Timeline
603mo left

Started Dec 1999

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress35%
Dec 1999Dec 2075

Study Start

First participant enrolled

December 1, 1999

Completed
16.1 years until next milestone

First Submitted

Initial submission to the registry

January 11, 2016

Completed
21 days until next milestone

First Posted

Study publicly available on registry

February 1, 2016

Completed
34.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2050

Expected
25 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2075

Last Updated

May 31, 2022

Status Verified

May 1, 2022

Enrollment Period

51 years

First QC Date

January 11, 2016

Last Update Submit

May 25, 2022

Conditions

LifestyleChronic DiseaseDietary Habits

Keywords

Nutritional epidemiologyProspective

Outcome Measures

Primary Outcomes (1)

  • Mortality

    50 years

Secondary Outcomes (4)

  • Cardiovascular disease

    50 years

  • Obesity

    50 years

  • Depression

    50 years

  • Cognitive function

    50 years

Study Arms (1)

No intervention

No Intervention

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Spanish university graduates

You may qualify if:

  • Spanish university graduates

You may not qualify if:

  • not Spanish university graduates

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Navarra

Pamplona, Navarre, 31008, Spain

Location

Related Publications (17)

  • Carlos S, De La Fuente-Arrillaga C, Bes-Rastrollo M, Razquin C, Rico-Campa A, Martinez-Gonzalez MA, Ruiz-Canela M. Mediterranean Diet and Health Outcomes in the SUN Cohort. Nutrients. 2018 Mar 31;10(4):439. doi: 10.3390/nu10040439.

    PMID: 29614726BACKGROUND

  • Segui-Gomez M, de la Fuente C, Vazquez Z, de Irala J, Martinez-Gonzalez MA. Cohort profile: the 'Seguimiento Universidad de Navarra' (SUN) study. Int J Epidemiol. 2006 Dec;35(6):1417-22. doi: 10.1093/ije/dyl223. Epub 2006 Oct 22. No abstract available.

    PMID: 17060332RESULT

  • de la O V, Goni L, Zazpe I, Martinez-Gonzalez MA, Santiago S, Bes-Rastrollo M, Ruiz-Canela M. Long-term risk of overweight/obesity according to the protein quality index in a prospective middle-aged cohort. Clin Nutr. 2025 Sep;52:284-298. doi: 10.1016/j.clnu.2025.07.024. Epub 2025 Jul 30.

    PMID: 40816209DERIVED

  • Gribble AK, Hershey MS, Lopez-Gil JF, Lan FY, Kales SN, Martinez-Gonzalez MA, Bes-Rastrollo M, Fernandez-Montero A. Role of the Intensity of Habitual Physical Activity in the Maintenance of Normal Blood Pressure: Findings From the SUN Longitudinal Cohort Study. J Am Heart Assoc. 2025 Jun 17;14(12):e038664. doi: 10.1161/JAHA.124.038664. Epub 2025 Jun 5.

    PMID: 40470663DERIVED

  • Martinez-Gonzalez MA. Should we remove wine from the Mediterranean diet?: a narrative review. Am J Clin Nutr. 2024 Feb;119(2):262-270. doi: 10.1016/j.ajcnut.2023.12.020. Epub 2023 Dec 28.

    PMID: 38157987DERIVED

  • Talavera-Rodriguez I, Fernandez-Lazaro CI, Hernandez-Ruiz A, Hershey MS, Galarregui C, Sotos-Prieto M, de la Fuente-Arrillaga C, Martinez-Gonzalez MA, Ruiz-Canela M. Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort. Eur J Nutr. 2023 Jun;62(4):1667-1680. doi: 10.1007/s00394-023-03099-8. Epub 2023 Feb 12.

    PMID: 36781422DERIVED

  • Bazal P, Gea A, Navarro AM, Salas-Salvado J, Corella D, Alonso-Gomez A, Fito M, Munoz-Bravo C, Estruch R, Fiol M, Lapetra J, Serra-Majem L, Ros E, Rekondo J, Munoz MA, Basora J, Sorli JV, Toledo E, Martinez-Gonzalez MA, Ruiz-Canela M. Caffeinated coffee consumption and risk of atrial fibrillation in two Spanish cohorts. Eur J Prev Cardiol. 2021 May 22;28(6):648-657. doi: 10.1177/2047487320909065.

    PMID: 34021573DERIVED

  • Alonso-Pedrero L, Ojeda-Rodriguez A, Zalba G, Razquin C, Martinez-Gonzalez MA, Bes-Rastrollo M, Marti A. Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort. Rev Esp Cardiol (Engl Ed). 2022 Apr;75(4):308-315. doi: 10.1016/j.rec.2021.04.002. Epub 2021 May 14. English, Spanish.

    PMID: 33994338DERIVED

  • Martin-Calvo N, Santiago Neri S, Segura G, Fernandez-Lazaro CI, Barberia-Latasa M, Martinez-Gonzalez MA. Pregestational BMI and higher offspring's risk of overweight/obesity in smoker and non-smoker mothers. Public Health Nutr. 2021 Sep;24(13):4204-4211. doi: 10.1017/S1368980020005194. Epub 2020 Dec 18.

    PMID: 33336642DERIVED

  • Hershey MS, Fernandez-Montero A, Sotos-Prieto M, Kales S, Gea A, Ruiz-Estigarribia L, Sanchez-Villegas A, Diaz-Gutierrez J, Martinez-Gonzalez MA, Ruiz-Canela M. The Association Between the Mediterranean Lifestyle Index and All-Cause Mortality in the Seguimiento Universidad de Navarra Cohort. Am J Prev Med. 2020 Dec;59(6):e239-e248. doi: 10.1016/j.amepre.2020.06.014. Epub 2020 Nov 18.

    PMID: 33220762DERIVED

  • Alonso-Pedrero L, Ojeda-Rodriguez A, Martinez-Gonzalez MA, Zalba G, Bes-Rastrollo M, Marti A. Ultra-processed food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project. Am J Clin Nutr. 2020 Jun 1;111(6):1259-1266. doi: 10.1093/ajcn/nqaa075.

    PMID: 32330232DERIVED

  • Gardeazabal I, Romanos-Nanclares A, Martinez-Gonzalez MA, Castello A, Sanchez-Bayona R, Perez-Gomez B, Razquin C, Aramendia-Beitia JM, Pollan M, Toledo E. Mediterranean dietary pattern is associated with lower incidence of premenopausal breast cancer in the Seguimiento Universidad de Navarra (SUN) Project. Public Health Nutr. 2020 Dec;23(17):3148-3159. doi: 10.1017/S1368980019003835. Epub 2020 Feb 24.

    PMID: 32090723DERIVED

  • Rico-Campa A, Martinez-Gonzalez MA, Alvarez-Alvarez I, Mendonca RD, de la Fuente-Arrillaga C, Gomez-Donoso C, Bes-Rastrollo M. Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study. BMJ. 2019 May 29;365:l1949. doi: 10.1136/bmj.l1949.

    PMID: 31142450DERIVED

  • Fresan U, Martinez-Gonzalez MA, Sabate J, Bes-Rastrollo M. Global sustainability (health, environment and monetary costs) of three dietary patterns: results from a Spanish cohort (the SUN project). BMJ Open. 2019 Feb 21;9(2):e021541. doi: 10.1136/bmjopen-2018-021541.

    PMID: 30796113DERIVED

  • Garcia-Arellano A, Martinez-Gonzalez MA, Ramallal R, Salas-Salvado J, Hebert JR, Corella D, Shivappa N, Forga L, Schroder H, Munoz-Bravo C, Estruch R, Fiol M, Lapetra J, Serra-Majem L, Ros E, Rekondo J, Toledo E, Razquin C, Ruiz-Canela M; SUN and PREDIMED Study Investigators. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies. Clin Nutr. 2019 Jun;38(3):1221-1231. doi: 10.1016/j.clnu.2018.05.003. Epub 2018 May 24.

    PMID: 30651193DERIVED

  • Mendonca RD, Carvalho NC, Martin-Moreno JM, Pimenta AM, Lopes ACS, Gea A, Martinez-Gonzalez MA, Bes-Rastrollo M. Total polyphenol intake, polyphenol subtypes and incidence of cardiovascular disease: The SUN cohort study. Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):69-78. doi: 10.1016/j.numecd.2018.09.012. Epub 2018 Oct 4.

    PMID: 30459074DERIVED

  • Mendonca RD, Pimenta AM, Gea A, de la Fuente-Arrillaga C, Martinez-Gonzalez MA, Lopes AC, Bes-Rastrollo M. Ultraprocessed food consumption and risk of overweight and obesity: the University of Navarra Follow-Up (SUN) cohort study. Am J Clin Nutr. 2016 Nov;104(5):1433-1440. doi: 10.3945/ajcn.116.135004. Epub 2016 Oct 12.

    PMID: 27733404DERIVED

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

Saliva

MeSH Terms

Conditions

Chronic DiseaseFeeding Behavior

Condition Hierarchy (Ancestors)

Disease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsBehavior, AnimalBehavior

Study Officials

  • Miguel A Martinez-Gonzalez, PhD

    University of Navarra

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 11, 2016

First Posted

February 1, 2016

Study Start

December 1, 1999

Primary Completion (Estimated)

December 1, 2050

Study Completion (Estimated)

December 1, 2075

Last Updated

May 31, 2022

Record last verified: 2022-05

Data Sharing

IPD Sharing
Will share

Locations

ES(1)