ABCFish2
Protists and Nematodes Fish Parasites: From Their Circulation in Ecosystems to Their Impact on Human Health - Role of Anisakidae and/or Fish Flesh Antigens in Fish Allergies.
Sponsor study identifier
Secondary identifiers
OTHER · ID RCB number, ANSM
observational
105
1 country
1
Study Start
February 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
January 2017
Actual (reported)Study Completion
January 2017
Actual (reported)Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic diseases agents, and have a high impact on human health. Infestation results from the ingestion of living larvae from contaminated fishes. It can be asymptomatic or symptomatic, resulting in acute gastric, acute intestinal or chronic forms. Allergic manifestations are frequently encountered in gastric forms, but allergic symptoms can also occur in isolation, after ingestion of Anisakidae antigens contained in raw or cooked fish, and may masquerade as fish allergy. In this study, we aim to characterize the relationship between Anisakidae and/or fish sensitization and the presence of allergic manifestations in patients recruited in the general population and presenting fish allergy resulting from ingestion, cutaneous or respiratory contact. We will also determine the respective role of Anisakidae or fish sensitization in patients with fish allergy. Then, we will determine the prevalence of previous Anisakidae infections among these patients and a matched control population. We will also compare the performances of serological tests (ImmunoCAP, immunoelectrophoresis and Western Blot) for the diagnosis of Anisakidae allergy or infection. Lastly, we will explore the relationship between domestic exposure to Anisakidae or fish antigens and the occurrence of associated pathologies (Anisakidae or fish allergy/sensitization; Anisakidae infection).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2017
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 2015
Date type not reportedThis date has not been verified as actual or estimated.
January 25, 2016
Actual (reported)January 28, 2016
Actual (reported)January 2017
Actual (reported)January 2017
Actual (reported)the frequency of anti-Anisakis and/or anti-fish IgE by serum analysis
comparison between subjects with fish allergy and a matched control population, presenting no fish allergy.
contact by phone during 30 min at only visit (inclusion)
anti-Anisakis and/or anti-fish IgE level by serum analysis
contact by phone during 30 min at only visit (inclusion)
the frequency of anti-Anisakis and anti-fish IgE in patients with fish allergy by serum analysis
contact by phone during 30 min at only visit (inclusion)
nomber of subjects of previous Anisakidae infections
contact by phone during 30 min at only visit (inclusion)
Measure of the performances of serological tests
at work medical visit (inclusion)
The frequency of domestic exposure to fish parasites antigens by questionnaire
contact by phone during 30 min at only visit (inclusion)
51 subjects presenting allergic manifestations after digestive, cutaneous, or respiratory contact with fish will be recruited. Interventions will include: * A questionnaire on domestic exposure to fish, and on the characteristics of clinical manifestations * A detection of anti-Anisakis and anti-fish antibodies
51 subjects presenting no allergic manifestations after contact with fish. Interventions will include: * A questionnaire on domestic exposure to fish * A detection of anti-Anisakis and anti-fish antibodies
Questionnaire on domestic exposure to fish, and, for patients with fish allergy, on the characteristics of clinical manifestations)
Anti-fish IgE will be detected using ImmunoCAP. Anti-Anisakis antibodies will be detected using ImmunoCAP (IgE), immunoelectrophoresis (precipitins) and Western Blot.
The recruited population will include: * 51 patients with fish allergy * 51 matched control subjects (sex, age +/- 5 years)
CHRU
Lille, France
Serum samples
Emmanuel DUTOIT, MD
University Hospital, Lille
105 participants (actual enrollment reported by the registry).
First Submitted
January 25, 2016
First Posted
January 28, 2016
Study Start
February 2015
Date type not reportedThis date has not been verified as actual or estimated.
Perception of Risks Into Work During Pregnancy Among Post-partum Women in the Lille Metropolis
Assessment of the Impact of Thoracic Outlet Syndromes on the Performance at Work
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
January 2017
Actual (reported)Study Completion
January 2017
Actual (reported)Last Updated
January 18, 2017
Record last verified: 2017-01
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: