Anisakis Blastocystis Cryptosporidium Fish Prevalence
ABCFish1
Protists and Nematodes Fish Parasites: From Their Circulation in Ecosystems to Their Impact on Human Health - Prevalence of Fish Allergy in Occupational Settings.
2 other identifiers
observational
486
1 country
3
Brief Summary
Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic agents, and have a high impact on human health. Infestation results from the ingestion of living larvae from contaminated fishes. It can be asymptomatic or symptomatic, resulting in acute gastric, acute intestinal or chronic forms. Allergic manifestations are frequently encountered in gastric forms, but isolated allergic symptoms can occur after ingestion of Anisakidae antigens in raw or cooked fish. Cutaneous contact or Anisakis allergen inhalation have also been reported to induce allergy/anaphylactic reactions or sensitization in the occupational setting in Spain, Italy, Sicilia or South Africa. But no data is available in France. In this context, the investigators propose to determine and compare the frequency and characteristics of fish allergy in fish workers (fishermen and fish-processing factory workers) and a control population of workers without occupational exposure to fish, in Boulogne-sur-Mer, which is an important fishing port in France, and the first European center for fish processing.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2014
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2014
CompletedFirst Submitted
Initial submission to the registry
January 13, 2016
CompletedFirst Posted
Study publicly available on registry
January 22, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2016
CompletedOctober 27, 2016
October 1, 2016
1.9 years
January 13, 2016
October 26, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The prevalence of fish allergy
Difference in the prevalence of fish allergy between occupationally exposed (fishermen and fish-processing factory workers) and non-exposed subjects. the fish allergy is definied by clinical diagnosis based on the presence of clinical manifestations of allergy in contact with the fish ( APC)
contact by phone during 30 min at only visit (inclusion)
Secondary Outcomes (4)
Frequencies history of infections Anisakis spp.
contact by phone during 30 min at only visit (inclusion)
Frequency of fish allergies, history of infections Anisakis spp. (clinical diagnosis)
contact by phone during 30 min at only visit (inclusion)
history of infections Anisakis spp. (clinical diagnosis)
contact by phone during 30 min at only visit (inclusion)
Frequency of risk factors for occupational or domestic exposure to fish:
contact by phone during 30 min at only visit (inclusion)
Study Arms (3)
Fishermen
Fisherman followed by the "Service de Santé des Gens de Mer" of Boulogne-sur-Mer, France (occupational exposure to fish). A questionnaire will be completed.
Fish processing factories
Workers of fish processing factories who are followed by the "Service de Santé au Travail" (ASTIL) of Boulogne-sur-Mer, France (occupational exposure to fish). A questionnaire will be completed.
Control
Workers who are followed by the "Service de Santé au Travail" (ASTIL) of Boulogne-sur-Mer, France, but do not work in fish processing factories. A questionnaire will be completed.
Interventions
A questionnaire will be completed in order to collect data on: * Potential allergic manifestations after fish contact: asthma, allergic rhinitis, conjunctivitis, chronic or acute urticaria, dermatitis/eczema, or severe allergic manifestations (angioedema, bronchospasm, anaphylaxis), * Occupational and/or domestic exposure to fish.
Eligibility Criteria
Study population will include the following 3 groups: * Fishermen followed by the "Service de Santé des Gens de Mer" of Boulogne-sur-Mer, * Fish-processing factory workers followed by the "Service de Santé au Travail" of Boulogne-sur-Mer, * A control group composed of workers followed by the "Service de Santé au Travail" of Boulogne-sur-Mer, but not working in a fish-processing factory.
You may qualify if:
- Fisherman followed by the "Service de Santé des Gens de Mer" of Boulogne-sur-Mer, fish-processing factory worker followed by the "Service de Santé au Travail" of Boulogne-sur-Mer, or worker followed by the "Service de Santé au Travail" of Boulogne-sur-Mer, but not working in a fish-processing factory.
You may not qualify if:
- Pregnant or breast-feeding female
- Patient with no social insurance
- Patient unwilling to comply with the protocol
- Patient unable to understand the study and its objectives
- Patient under guardianship
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University Hospital, Lillelead
- Institut Pasteur de Lillecollaborator
- ANSEScollaborator
- Région Nord-Pas de Calais, Francecollaborator
Study Sites (3)
Centre ASTIL
Boulogne-sur-Mer, France
Service de Santé des Gens de Mer
Boulogne-sur-Mer, France
CHRU
Lille, France
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Emmanuel DUTOIT, MD
University Hospital, Lille
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 13, 2016
First Posted
January 22, 2016
Study Start
November 1, 2014
Primary Completion
October 1, 2016
Study Completion
October 1, 2016
Last Updated
October 27, 2016
Record last verified: 2016-10
Data Sharing
- IPD Sharing
- Will not share