Effects of Acute Exercise on Various Parameters in Individuals With Alcohol Use Disorders

NCT02664727 | Completed

• 1 other identifier: UThessaly
• Study Type: interventional
• Target: 13
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this research is to examine the effects of exercise of different intensities on psychological, physiological, biochemical, physiological and alcohol-related parameters in individuals with alcohol use disorders (heavy drinkers and alcoholic patients) in order to investigate possible biochemical mechanisms by which exercise may be a healthy alternative to alcohol abuse. For that purpose, a control group of individuals that do not exceed the limits for moderate alcohol use will be included.

Conditions

Heavy Drinking; Alcohol Abuse; Alcohol Dependence; Alcohol Use Disorder

Keywords

alcohol; alcohol abuse; alcohol dependence; alcohol use disorder; heavy drinking; alcohol abuse cessation

Outcome Measures

Primary Outcomes (12)

• Changes in Urge to drink score

  According to questionnaire

  Before (0 min) and after exercise trial (30 min)

• Changes in Beta-endorphin levels

  Measured by radioimmunoassay (RIA)

  Before (0 min) and after exercise trial (30 min)

• Changes in Cortisol levels

  Measured by radioimmunoassay (RIA)

  Before (0 min) and after exercise trial (30 min)

• Changes in Adrenocorticotrophic hormone (ACTH) levels

  Measured by radioimmunoassay (RIA)

  Before (0 min) and after exercise trial (30 min)

• Changes in Catecholamines (epinephrine, norepinephrine, dopamine) levels

  Measured by radioimmunoassay (RIA)

  Before (0 min) and after exercise trial (30 min)

• Changes in C-reactive protein (CRP) levels

  Semi-quantitative estimation with CRP Latex test kit

  Before (0 min) and after exercise trial (30 min)

• Changes in Complete blood count values

  Autoanalyzer

  Before (0 min) and after exercise trial (30 min)

• Changes in Lactic acid levels

  Measured using photometry

  Before (0 min) and after exercise trial (30 min)

• Changes in Erythrocyte sedimentation rate (ESR) values

  Wintrobe Method

  Before (0 min) and after exercise trial (30 min)

• Changes in γ-Glutamyltransferase (GGT) levels

  Measured with commercial kit

  Before (0 min) and after exercise trial (30 min)

• Changes in Aspartate Aminotransferase (AST) levels

  Measured with commercial kit

  Before (0 min) and after exercise trial (30 min)

• Changes in Alanine Aminotransferase (ALT) levels

  Measured with commercial kit

  Before (0 min) and after exercise trial (30 min)

Secondary Outcomes (4)

• Sit and reach flexibility test for the hamstrings muscles and lower back

  Before trial (baseline)

• Grip strength

  Before trial (baseline)

• Number of push-ups performed in one minute

  Before trial (baseline)

• Number of sit-ups performed until exhaustion

  Before trial (baseline)

Study Arms (2)

Heavy drinkers

EXPERIMENTAL

The effects of acute exercise in heavy drinkers. Participants will cycle on ergometer for 30 min at 50-60% of Heart Rate Reserve (HRR).

Behavioral: The effects of acute exercise in heavy drinkers

Alcoholic patients

EXPERIMENTAL

The effects of acute exercise in alcoholic patients. Participants will cycle on ergometer for 30 min at 55-60% of Heart Rate maximal (HRmax).

Behavioral: The effects of acute exercise in alcoholic patients

Interventions

The effects of acute exercise in heavy drinkers BEHAVIORAL

A group of heavy drinkers and a group of healthy controls (individuals without alcohol use disorders) will cycle on a cycle ergometer for 30 min at 50-60% of HRR. Before and immediately after exercise blood will be drawn and psychological and physiological parameters will be measured.

Heavy drinkers

The effects of acute exercise in alcoholic patients BEHAVIORAL

A group of alcoholic patients (10-14 days after detoxification) and a group of healthy controls (individuals without alcohol use disorders) will cycle on a cycle ergometer for 30 min at 55-60% of HRmax. Before and immediately after exercise blood will be drawn and psychological and physiological parameters will be measured.

Alcoholic patients

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Confirmed alcohol addiction according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria in the past, after detoxification phase, lack of dependence on other substances
• Alcohol Use Disorders Identification Test (AUDIT) score\>20

You may not qualify if:

• Medical conditions or medication use that would preclude participation in aerobic exercise
• For heavy drinkers:
• Men drinking \>14 drinks/week or \>4 drinks/occasion; Women drinking \>7 drinks/week or \>4 drinks/occasion (1 drink = 14 grams of pure alcohol; definition of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) for drinking at low risk for developing an AUD; NIAAA, 2014)
• Individuals drinking 5 or more drinks on the same occasion on each of 5 or more days in the past 30 days (1 drink = 14 grams of pure alcohol; definition of the Substance Abuse and Mental Health Services Administration for heavy drinking; NIAAA, 2014)
• AUDIT score\>8
• Medical conditions or medication use that would preclude participation in aerobic exercise
• For healthy controls:
• Men drinking \<14 drinks/week or \<4 drinks/occasion; Women drinking \<7 drinks/week or \<4 drinks/occasion (1 drink = 14 grams of pure alcohol; definition of the NIAAA for drinking at low risk for developing an AUD; NIAAA, 2014)
• Individuals drinking \<5 drinks on the same occasion on each of 5 or more days in the past 30 days (1 drink = 14 grams of pure alcohol; definition of the Substance Abuse and Mental Health Services Administration for heavy drinking; NIAAA, 2014)
• AUDIT score\<8
• Medical conditions or medication use that would preclude participation in aerobic exercise

Sponsors & Collaborators

• University of Thessaly: lead
• European Social Fund: collaborator

Related Publications (1)

• Georgakouli K, Manthou E, Fatouros IG, Deli CK, Spandidos DA, Tsatsakis AM, Kouretas D, Koutedakis Y, Theodorakis Y, Jamurtas AZ. Effects of acute exercise on liver function and blood redox status in heavy drinkers. Exp Ther Med. 2015 Dec;10(6):2015-2022. doi: 10.3892/etm.2015.2792. Epub 2015 Oct 13.

  PMID: 26668589 RESULT

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Yannis Theodorakis, PhD

  University of Thessaly

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: January 15, 2016
• First Posted: January 27, 2016
• Study Start: January 1, 2014
• Primary Completion: March 1, 2014
• Study Completion: June 1, 2014
• Last Updated: January 28, 2016

Record last verified: 2016-01

Data Sharing

• IPD Sharing: Will not share