The Effects of Acute Caloric Deprivation on Odour Identification and Food Reward
DEXDER
1 other identifier
interventional
10
0 countries
N/A
Brief Summary
The purpose of this study is to determine how the modality of energy depletion can differently impact appetite hormones, ad libitum food intake, food hedonics, and olfaction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Nov 2009
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2012
CompletedFirst Submitted
Initial submission to the registry
January 6, 2016
CompletedFirst Posted
Study publicly available on registry
January 12, 2016
CompletedJanuary 12, 2016
January 1, 2016
2.3 years
January 6, 2016
January 8, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Change in Ad Libitum Energy Intake at Buffet Lunch--total kcals consumed at lunch meal measured to nearest 0.5grams.
Ad libitum measure of energy intake at lunch time at Day 1 and Day 4 of study
Day 1 and Day 4 of each study arm (DIET and EX)
Secondary Outcomes (4)
Change in fasting measure of Leptin
Day 1 and Day 4 of each study arm (DIET and EX)
Change in fasting measure of Ghrelin
Day 1 and Day 4 of each study arm (DIET and EX)
Change in Relative-Reinforcing Value of Food as measured by food points earned during a computerized behavioral choice tast
Day 1 and Day 4 of each study arm (DIET and EX)
Olfaction--Odor Detection Threshold measured by Sniffin Sticks odorized pens
Day 1 and Day 4 of each study arm (DIET and EX)
Study Arms (2)
DIET ARM
ACTIVE COMPARATORA 25% energy depletion (daily for 3 days) induced by reducing the amount of energy intake that would otherwise keep the individual in energy balance.
EX ARM
ACTIVE COMPARATORA 25% energy depletion (daily for 3 days) induced by performing aerobic exercise at 50% of V02max.
Interventions
Eligibility Criteria
You may qualify if:
- Free from any illness that could influence outcome of the experiment
- Weight-stable for \>6months
- aged between 18-40 years
You may not qualify if:
- diabetic
- smoker
- medication
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
McNeil J, Lamothe G, Cameron JD, Riou ME, Cadieux S, Lafreniere J, Goldfield G, Willbond S, Prud'homme D, Doucet E. Investigating predictors of eating: is resting metabolic rate really the strongest proxy of energy intake? Am J Clin Nutr. 2017 Nov;106(5):1206-1212. doi: 10.3945/ajcn.117.153718. Epub 2017 Sep 6.
PMID: 28877891DERIVEDCameron JD, Goldfield GS, Riou ME, Finlayson GS, Blundell JE, Doucet E. Energy depletion by diet or aerobic exercise alone: impact of energy deficit modality on appetite parameters. Am J Clin Nutr. 2016 Apr;103(4):1008-16. doi: 10.3945/ajcn.115.115584. Epub 2016 Feb 17.
PMID: 26888712DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Eric Doucet, PhD
University of Ottawa
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Human Kinetics
Study Record Dates
First Submitted
January 6, 2016
First Posted
January 12, 2016
Study Start
November 1, 2009
Primary Completion
March 1, 2012
Study Completion
March 1, 2012
Last Updated
January 12, 2016
Record last verified: 2016-01
Data Sharing
- IPD Sharing
- Will not share