NCT02650258

Brief Summary

The purpose of this study is to determine and link cadence (the number of steps taken in a minute) to the intensity of physical activity (e.g. low-, moderate- and vigorous-intensity) in adults (21-85 years old). The investigators anticipate that cadence will be a good indicator of exercise intensity. Identifying how cadence relates to activity intensity will allow for physical activity guidelines to be communicated to the public in a manner that is more accessible to the lay person.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
260

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Dec 2015

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2015

Completed
23 days until next milestone

First Submitted

Initial submission to the registry

December 24, 2015

Completed
15 days until next milestone

First Posted

Study publicly available on registry

January 8, 2016

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 5, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 5, 2019

Completed
Last Updated

December 6, 2022

Status Verified

October 1, 2020

Enrollment Period

3.7 years

First QC Date

December 24, 2015

Last Update Submit

December 2, 2022

Conditions

Outcome Measures

Primary Outcomes (2)

  • Cadence (steps/min) as assessed by observation (hand tallied counts) of cadence

    The identification of cadence value cut-points associated with low, moderate and vigorous activity.

    Cross-sectional data; single time point, throughout study, up to 5 years

  • Monitor validation (difference in steps/min compared to observation/hand tallied counts)

    Compare the ability of different activity monitors to accurately measure cadence

    Cross-sectional data; single time point, throughout study, up to 5 years

Study Arms (3)

Young Adult

80 Adults 21-40 years of age: 10 Male and 10 Female in each 5 year increment (21-25, 26-30, 31-35, 36-40).

Behavioral: treadmill walking

Middle Aged Adults

80 Adults 41-60 years of age: 10 Male and 10 Female in each 5 year increment (41-45, 46-50, 51-55, 56-60).

Behavioral: treadmill walking

Older Adults

100 Adults 61-85 years of age: 10 Male and 10 Female in each 5 year increment (61-65, 66-69, 70-75, 76-80, 81-85).

Behavioral: treadmill walking

Interventions

all participants walking at increasing speeds on a treadmill

Middle Aged AdultsOlder AdultsYoung Adult

Eligibility Criteria

Age21 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

A convenience sample from the surrounding community of male and females 21-85 years will be recruited as participants. Specifically, 10 men and 10 women for each 5-year age-group category (21-25, 26-30, 31-35, etc.) will be collected.

You may qualify if:

  • Adults between ages 21-85 years, able to ambulate on a treadmill (self-report)

You may not qualify if:

  • BMI less than 18.5 or more than 40kg/m\^2
  • Having smoked tobacco within the past 6 months
  • wheelchair bound, or conditions that prevent normal ambulation
  • Resting systolic blood pressure \> 159 mm HG, or diastolic blood pressure \> 99 mm HG
  • Hospitalization for mental illness within the past 5 years (for the 41-60 and 61-85 year old cohorts this was change to "within the past 1 year").
  • Any condition/medication that may affect heart rate response to exercise testing.
  • Previous history of, or clinical symptoms or signs of, cardiovascular disease, stroke or transient ischemic attacks, chest pain, unusual dyspnea during physical activity/exercise, severe ankle swelling, or leg pain while walking.
  • Any significant medical condition that may interfere with the study.
  • Previous history of musculoskeletal injuries or problems causing severe pain during physical activity or exercise which interferes with daily activities.
  • Participant has a pacemaker or other implanted medical device (including metal joint replacements).
  • Participant is pregnant.
  • Participant is unable to complete all testing (1 or two sessions, based on risk factors) within a maximal two week period.
  • Individuals wearing a full beard may need to be excluded from the study, as large amounts of facial hair around the mouth and nose interfere with the seal of the device that measures the air you breath. Because of this we are seeking participants that are clean-shaven or with a beard where areas around the nose and mouth are clean-shaven (e.g. goatee).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Walking Research Laboratory, University of North Carolina at Charlotte

Charlotte, North Carolina, 28223, United States

Location

Related Publications (15)

  • Tudor-Locke C, Rowe DA. Using cadence to study free-living ambulatory behaviour. Sports Med. 2012 May 1;42(5):381-98. doi: 10.2165/11599170-000000000-00000.

    PMID: 22462794BACKGROUND
  • Tudor-Locke C, Sisson SB, Collova T, Lee SM, Swan PD. Pedometer-determined step count guidelines for classifying walking intensity in a young ostensibly healthy population. Can J Appl Physiol. 2005 Dec;30(6):666-76. doi: 10.1139/h05-147.

    PMID: 16485518BACKGROUND
  • Tudor-Locke C, Camhi SM, Leonardi C, Johnson WD, Katzmarzyk PT, Earnest CP, Church TS. Patterns of adult stepping cadence in the 2005-2006 NHANES. Prev Med. 2011 Sep;53(3):178-81. doi: 10.1016/j.ypmed.2011.06.004. Epub 2011 Jun 25.

    PMID: 21708187BACKGROUND
  • Tudor-Locke C, Han H, Aguiar EJ, Barreira TV, Schuna JM Jr, Kang M, Rowe DA. How fast is fast enough? Walking cadence (steps/min) as a practical estimate of intensity in adults: a narrative review. Br J Sports Med. 2018 Jun;52(12):776-788. doi: 10.1136/bjsports-2017-097628.

    PMID: 29858465BACKGROUND
  • Moore CC, McCullough AK, Aguiar EJ, Ducharme SW, Tudor-Locke C. Toward Harmonized Treadmill-Based Validation of Step-Counting Wearable Technologies: A Scoping Review. J Phys Act Health. 2020 Jul 11;17(8):840-852. doi: 10.1123/jpah.2019-0205. Print 2020 Aug 1.

    PMID: 32652514BACKGROUND
  • Tudor-Locke C, Aguiar EJ, Han H, Ducharme SW, Schuna JM Jr, Barreira TV, Moore CC, Busa MA, Lim J, Sirard JR, Chipkin SR, Staudenmayer J. Walking cadence (steps/min) and intensity in 21-40 year olds: CADENCE-adults. Int J Behav Nutr Phys Act. 2019 Jan 17;16(1):8. doi: 10.1186/s12966-019-0769-6.

  • Tudor-Locke C, Ducharme SW, Aguiar EJ, Schuna JM Jr, Barreira TV, Moore CC, Chase CJ, Gould ZR, Amalbert-Birriel MA, Mora-Gonzalez J, Chipkin SR, Staudenmayer J. Walking cadence (steps/min) and intensity in 41 to 60-year-old adults: the CADENCE-adults study. Int J Behav Nutr Phys Act. 2020 Nov 10;17(1):137. doi: 10.1186/s12966-020-01045-z.

  • Tudor-Locke C, Mora-Gonzalez J, Ducharme SW, Aguiar EJ, Schuna JM Jr, Barreira TV, Moore CC, Chase CJ, Gould ZR, Amalbert-Birriel MA, Chipkin SR, Staudenmayer J. Walking cadence (steps/min) and intensity in 61-85-year-old adults: the CADENCE-Adults study. Int J Behav Nutr Phys Act. 2021 Sep 23;18(1):129. doi: 10.1186/s12966-021-01199-4.

  • McAvoy CR, Moore CC, Aguiar EJ, Ducharme SW, Schuna JM Jr, Barreira TV, Chase CJ, Gould ZR, Amalbert-Birriel MA, Chipkin SR, Staudenmayer J, Tudor-Locke C, Mora-Gonzalez J. Correction: Cadence (steps/min) and relative intensity in 21 to 60-year-olds: the CADENCE-adults study. Int J Behav Nutr Phys Act. 2022 Jun 2;19(1):62. doi: 10.1186/s12966-022-01295-z. No abstract available.

  • Mora-Gonzalez J, Gould ZR, Moore CC, Aguiar EJ, Ducharme SW, Schuna JM Jr, Barreira TV, Staudenmayer J, McAvoy CR, Boikova M, Miller TA, Tudor-Locke C. A catalog of validity indices for step counting wearable technologies during treadmill walking: the CADENCE-adults study. Int J Behav Nutr Phys Act. 2022 Sep 8;19(1):117. doi: 10.1186/s12966-022-01350-9.

  • Moore CC, Aguiar EJ, Ducharme SW, Tudor-Locke C. Development of a Cadence-based Metabolic Equation for Walking. Med Sci Sports Exerc. 2021 Jan;53(1):165-173. doi: 10.1249/MSS.0000000000002430.

  • Aguiar EJ, Gould ZR, Ducharme SW, Moore CC, McCullough AK, Tudor-Locke C. Cadence-based Classification of Minimally Moderate Intensity During Overground Walking in 21- to 40-Year-Old Adults. J Phys Act Health. 2019 Dec 1;16(12):1092-1097. doi: 10.1123/jpah.2019-0261. Epub 2019 Nov 6.

  • Ducharme SW, Lim J, Busa MA, Aguiar EJ, Moore CC, Schuna JM Jr, Barreira TV, Staudenmayer J, Chipkin SR, Tudor-Locke C. A Transparent Method for Step Detection using an Acceleration Threshold. J Meas Phys Behav. 2021 Dec;4(4):311-320. doi: 10.1123/jmpb.2021-0011. Epub 2021 Oct 25.

  • McAvoy CR, Miller TA, Aguiar EJ, Ducharme SW, Moore CC, Schuna JM Jr, Barreira TV, Chase CJ, Gould ZR, Amalbert-Birriel MA, Chipkin SR, Staudenmayer J, Tudor-Locke C, Bucko A, Mora-Gonzalez J. Cadence (steps/min) and relative intensity in 61 to 85-year-olds: the CADENCE-Adults study. Int J Behav Nutr Phys Act. 2023 Nov 29;20(1):141. doi: 10.1186/s12966-023-01543-w.

  • McAvoy CR, Moore CC, Aguiar EJ, Ducharme SW, Schuna JM Jr, Barreira TV, Chase CJ, Gould ZR, Amalbert-Birriel MA, Chipkin SR, Staudenmayer J, Tudor-Locke C, Mora-Gonzalez J. Cadence (steps/min) and relative intensity in 21 to 60-year-olds: the CADENCE-adults study. Int J Behav Nutr Phys Act. 2021 Feb 10;18(1):27. doi: 10.1186/s12966-021-01096-w.

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

  • Catrine Tudor-Locke, PhD

    University of North Carolina at Charlotte

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 24, 2015

First Posted

January 8, 2016

Study Start

December 1, 2015

Primary Completion

August 5, 2019

Study Completion

August 5, 2019

Last Updated

December 6, 2022

Record last verified: 2020-10

Data Sharing

IPD Sharing
Will share

Requests for de-identified individual-level data (including descriptors) collected in CADENCE-Adults and used in publications will be considered and made available to qualified researchers within 2 years of publication of the associated paper. Data sharing agreements will be necessary for access.The CADENCE-Adults data base will be maintained and access ensured by the Physical Activity and Health Laboratory in the Department of Kinesiology at University of Massachusetts Amherst.

Shared Documents
STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
Time Frame
Researchers can request supporting information for two years post-publication
Access Criteria
Contact PI

Locations