NCT02638181

Brief Summary

This study was to assess the distinct expression of matrix metalloproteinase 13,tissue inhibitor of metalloproteinases 3, and calcium-sensing receptor, in human trabecular meshwork between normal and glaucomatous eyes.The expressions of matrix metalloproteinase 13, tissue inhibitor of metalloproteinases 3 and calcium-sensing receptor in the trabecular meshwork tissues were examined by streptavidin-peroxidase immunohistochemical staining method and western blot, and histological changes of trabecular meshwork were studied by Hematoxylin and Eosin staining.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jul 2013

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2013

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2015

Completed
13 days until next milestone

First Submitted

Initial submission to the registry

December 14, 2015

Completed
9 days until next milestone

First Posted

Study publicly available on registry

December 23, 2015

Completed
Last Updated

January 10, 2017

Status Verified

January 1, 2017

Enrollment Period

2.4 years

First QC Date

December 14, 2015

Last Update Submit

January 8, 2017

Conditions

Open-angle Glaucoma

Keywords

matrix metalloproteinase 13tissue inhibitor of metalloproteinases 3calcium-sensing receptortrabecular meshworkopen-angle glaucoma

Outcome Measures

Primary Outcomes (1)

  • the expressions of matrix metalloproteinase 13 and calcium-sensing receptor

    one hour after operation

Secondary Outcomes (1)

  • histological changes of trabecular meshwork

    one hour after operation

Study Arms (1)

trabeculectomy

EXPERIMENTAL
Procedure: trabeculectomy

Interventions

trabeculectomyPROCEDURE
trabeculectomy

Eligibility Criteria

Age50 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • intraocular pressure greater than 22 mmHg with two or more medications
  • wide anterior chamber angle
  • glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect
  • visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

You may not qualify if:

  • the presence of any secondary form of glaucoma including exfoliation syndrome or a history of ocular trauma, etc

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Tianjin Medical University Eye Hospital

Tianjin, Tianjin Municipality, 300384, China

Location

MeSH Terms

Conditions

Glaucoma, Open-Angle

Interventions

Trabeculectomy

Condition Hierarchy (Ancestors)

GlaucomaOcular HypertensionEye Diseases

Intervention Hierarchy (Ancestors)

Filtering SurgeryOphthalmologic Surgical ProceduresSurgical Procedures, Operative

Study Officials

  • xiaorong li

    Tianjin Medical University Eye Hospital

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
department of ophthamology

Study Record Dates

First Submitted

December 14, 2015

First Posted

December 23, 2015

Study Start

July 1, 2013

Primary Completion

December 1, 2015

Study Completion

December 1, 2015

Last Updated

January 10, 2017

Record last verified: 2017-01

Locations

CN(1)