Study Stopped
It was no longer possible to include patients due to logistic challanges occuring during the Covid-19 pandemic
Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain
WESTCOR
1 other identifier
observational
1,900
1 country
2
Brief Summary
The main aim of the WESTCOR study is to
- investigate the ability of two high sensitive cardiac troponin (hs-cTn) assays to diagnose acute coronary syndrome and predict prognosis in different patient populations (e.g. gender, age and co-morbidity)
- to validate the suggested 1 hour protocol for rule in and rule out of acute coronary syndrome for two hs-cTn assays in an unselected chest pain population
- to investigate different biomarkers ability to predict long term prognosis after hospitalization for chest pain
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2015
Longer than P75 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2015
CompletedFirst Submitted
Initial submission to the registry
October 12, 2015
CompletedFirst Posted
Study publicly available on registry
December 2, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2020
CompletedApril 28, 2021
July 1, 2020
4.7 years
October 12, 2015
April 26, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of patients with chest pain that are diagnosed with acute coronary syndrome based on troponin concentrations
Stratified according to gender, age and co-morbidities
1-3 hours
Other Outcomes (5)
Number of patients with chest pain that are diagnosed with NSTEMI based on troponin concentration
1-3 hours
Total mortality
5 years
The incidence of major cardiovascular events (MACE) defined as (composite endpoint including MI, UAP, stable angina (requiring hospitalization), revascularization, stroke, heart failure and cardiac arrhythmias)
5 years
- +2 more other outcomes
Eligibility Criteria
Patients admitted to the Emergency Department at Haukeland University Hospital or Stavanger University Hospital with symptoms indicative of acute coronary syndrome
You may qualify if:
- Patients admitted to the Emergency Department with a clinical suspicion of acute coronary syndrome i.e. chest pain or pain radiating down the arms, the back, into the jaw, throat or into the lower teeth. Chest pain must not be the most dominant symptom but may or may not be combined with e.g. dyspnea, nausea, anxiousness or palpitations.
- Age \>= 18 years
You may not qualify if:
- ST elevation MI
- Age \< 18 years
- Patients not able to give informed consent
- Patients suffering from terminal illness (life expectance \< 1 month)
- Patients already included in the study
- Patients who have been stabilized at local hospitals and are referred for second opinion e.g. coronary angiography
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Haukeland University Hospitallead
- Helse Stavanger HFcollaborator
- The Royal Norwegian Ministry of Healthcollaborator
Study Sites (2)
Haukeland University Hospital
Bergen, 5020, Norway
Stavanger University Hospital
Stavanger, 4011, Norway
Related Publications (4)
Saeed N, Restan IZ, Steiro OT, Tjora HL, Langorgen J, Skadberg O, Mjelva OR, Bonarjee VVS, Bjorneklett RO, Steinsvik T, Vikenes K, Omland T, Apple FS, Jaffe AS, Mills NL, Collinson PO, Kavsak PA, Aakre KM. Analytical Error of Cardiac Troponin and Impact on the Performance of Accelerated Diagnostic Protocols in Patients with Acute Chest Pain. Clin Chem. 2025 Dec 2;71(12):1243-1256. doi: 10.1093/clinchem/hvaf116.
PMID: 41092105DERIVEDSaeed N, Steiro OT, Langorgen J, Tjora HL, Bjorneklett RO, Skadberg O, Bonarjee VVS, Mjelva OR, Norekval TM, Steinsvik T, Vikenes K, Omland T, Aakre KM. Diagnosing Myocardial Injury in an Acute Chest Pain Cohort; Long-Term Prognostic Implications of Cardiac Troponin T and I. Clin Chem. 2024 Oct 3;70(10):1241-1255. doi: 10.1093/clinchem/hvae110.
PMID: 39119917DERIVEDSaeed N, Norekval TM, Steiro OT, Tjora HL, Langorgen J, Bjorneklett RO, Skadberg O, Bonarjee VVS, Mjelva OR, Omland T, Vikenes K, Aakre KM. Predictors of long-term symptom burden and quality of life in patients hospitalised with chest pain: a prospective observational study. BMJ Open. 2022 Jul 13;12(7):e062302. doi: 10.1136/bmjopen-2022-062302.
PMID: 35831040DERIVEDSteiro OT, Aakre KM, Tjora HL, Bjorneklett RO, Skadberg O, Bonarjee VVS, Mjelva OR, Omland T, Vikenes K, Langorgen J. Association between symptoms and risk of non-ST segment elevation myocardial infarction according to age and sex in patients admitted to the emergency department with suspected acute coronary syndrome: a single-centre retrospective cohort study. BMJ Open. 2022 May 12;12(5):e054185. doi: 10.1136/bmjopen-2021-054185.
PMID: 35551077DERIVED
Biospecimen
Full blood, Serum samples, EDTA plasma, Urine
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kristin M Aakre, MD, PhD
Laboratory of Clinical Biochemistry, Haukeland University Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 12, 2015
First Posted
December 2, 2015
Study Start
September 1, 2015
Primary Completion
May 1, 2020
Study Completion
May 1, 2020
Last Updated
April 28, 2021
Record last verified: 2020-07