Effects of Standing and Light-intensity Activity on Ambulatory Blood Pressure and Blood Glucose

NCT02616809 | Completed Phase 3

• 1 other identifier: 1306009298
• Study Type: interventional
• Target: 10
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to test the short-term effects of intermittent standing, slow cycling and slow walking, compared to sitting, on continuous blood glucose and ambulatory blood pressure among pre-hypertensive and pre-diabetic adults.

Conditions

Diabetes; Hypertension; Sleep

Outcome Measures

Primary Outcomes (2)

• Evidence of change in blood pressure following changes in posture and increasing energy expenditure

  single-day intervention

• Evidence of change in blood glucose following changes in posture and increasing energy expenditure

  single-day intervention

Study Arms (4)

Sitting

EXPERIMENTAL

Participants will sit continuously for 8 hours in a simulated office environment

Other: Maintaining posture and energy expenditure

slow cycling

EXPERIMENTAL

Participants will cycle at regular hourly intervals during an 8-hr simulated office environment

Other: Increasing energy expenditure

standing

EXPERIMENTAL

Participants will change posture (from sitting to standing) during hourly intervals for an 8-hr period in a simulated office environment

Other: Changing posture

slow walking

EXPERIMENTAL

Participants will transition from sitting to slow walking on a treadmill desk at regular hourly intervals during an 8-hr period in a simulated office environment

Other: Increasing energy expenditure and changing posture

Interventions

Maintaining posture and energy expenditure OTHER

Participants will sit continuously for 8-hrs during a simulated office environment

Sitting

Increasing energy expenditure OTHER

Participants will cycle slowly while seated in prescribed hourly intervals. This condition will increase energy expenditure while keeping a sitting posture

slow cycling

Changing posture OTHER

Participants will transition from sitting to standing in prescribed hourly intervals. This condition will change posture (sit to stand) while maintaining low energy expenditure

standing

Increasing energy expenditure and changing posture OTHER

Participants will transition from sitting to a walking workstation in prescribed hourly intervals. This condition will both increase energy expenditure and change posture.

slow walking

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• pre-hypertensive (systolic blood pressure 120-139 mmHg, or diastolic blood pressure 80-89 mmHg)
• impaired fasting glucose (5.6-6.9 mmil/L)
• not meeting the physical activity guidelines for adults (\>=150 min/wk of moderate-to-vigorous physical activity)

You may not qualify if:

• smoking, pregnancy, known coronary heart disease, orthopedic limitations for performing physical activity, taking medications to control high blood pressure or high blood glucose, special dietary requirements, and being advised by a doctor to avoid prolonged periods of sitting.

Sponsors & Collaborators

• Arizona State University: lead

MeSH Terms

Conditions

Diabetes Mellitus; Hypertension

Interventions

Energy Metabolism

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Metabolism

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 24, 2015
• First Posted: November 30, 2015
• Study Start: July 1, 2014
• Primary Completion: April 1, 2015
• Study Completion: April 1, 2015
• Last Updated: November 30, 2015

Record last verified: 2015-11