NCT02610179

Brief Summary

The goal of this prospective study is to determine whether there is superiority of 10 Twizzlers to the 50 gram glucola beverage for screening for GDM in a population based study.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
617

participants targeted

Target at P75+ for not_applicable

Timeline
9mo left

Started Apr 2015

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress94%
Apr 2015Mar 2027

Study Start

First participant enrolled

April 1, 2015

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

November 13, 2015

Completed
7 days until next milestone

First Posted

Study publicly available on registry

November 20, 2015

Completed
9.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2025

Completed
2.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2027

Expected
Last Updated

May 11, 2023

Status Verified

May 1, 2023

Enrollment Period

9.8 years

First QC Date

November 13, 2015

Last Update Submit

May 9, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • The serum glucose levels will be measured in response to oral glucose challenge and compared between Twizzlers and glucola beverage.

    Each participant will have a blood draw to check the serum glucose level.

    24 to 28 weeks gestation

Secondary Outcomes (1)

  • Cost-effectiveness

    24 to 28 weeks gestation

Study Arms (2)

Standard Glucola GCT

ACTIVE COMPARATOR

A prospective cohort of 617 women who will undergo screening for gestational diabetes with the standard glucola GCT between 24 and 28 weeks gestational age.

Dietary Supplement: Standard Glucola GCT

Twizzlers challenge

EXPERIMENTAL

At a later date, the same prospective cohort of 617 women Participants will receive their Twizzlers challenge between 24 and 28 weeks gestational age.

Dietary Supplement: Twizzlers challenge

Interventions

Standard Glucola GCTDIETARY_SUPPLEMENT

Participants will be screened with the standard method of consumption of the glucola beverage followed by a 1 hour venous blood draw.

Standard Glucola GCT
Twizzlers challengeDIETARY_SUPPLEMENT

Participants will consume the Twizzlers equivalent (10 strawberry flavored Twizzlers) and have their venous blood glucose checked in 1 hour.

Twizzlers challenge

Eligibility Criteria

Age18 Years - 64 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Pregnant
  • to 28 weeks gestation
  • Singleton or twin or triplet gestation
  • Willing to participate in the study

You may not qualify if:

  • Known Type II DM
  • Known Type I DM
  • On oral or injectable corticosteroids
  • gram glucola beverage GCT of greater than or equal to 190 mg/dl

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ben Taub General Hospital

Houston, Texas, 77030, United States

RECRUITING

MeSH Terms

Conditions

Diabetes, Gestational

Condition Hierarchy (Ancestors)

Pregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Kjersti Aagaard, MD, PhD

    Baylor College of Medicine

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Kjersti Aagaard, MD, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

November 13, 2015

First Posted

November 20, 2015

Study Start

April 1, 2015

Primary Completion

January 1, 2025

Study Completion (Estimated)

March 1, 2027

Last Updated

May 11, 2023

Record last verified: 2023-05

Locations