Food Frequency Questionnaires in Estimating Food Nutrient Intake in Healthy Young Adults

NCT02610023 | Active Not Recruiting DMC

• 2 other identifiers: OSU 14222NCI-2015-00069
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Fruits and vegetables are an important source of many different phytochemicals that may affect health and accurate dietary assessement tools to quantitate dietary intake are essential. This study will evaluate the correlation of dietary carotenoid intake estimated from two common and one novel food frequency questionnaire (FFQ) with estimated carotenoid intake from 3 day diet records as well as measured blood and skin concentrations of carotenoids. This study will be conducted in healthy adults. These tools may be effective in estimating the level of these compounds in an average diet.

Conditions

Healthy Subject

Outcome Measures

Primary Outcomes (3)

• FFQ estimated carotenoid intake

  The relationship between the carotenoid values from the FFQ, both the unadjusted and the energy-adjusted estimates, and averages of the 3-day diet records will be estimated using the Pearson correlation coefficients. Statistical analysis will be conducted using Stata version 11.

  Up to 3 months

• Levels of carotenoids in plasma

  Pearson correlations will be used to compare plasma levels of individual carotenoids with their respective dietary intake after adjustment for total energy, plasma cholesterol, plasma triglycerides, and BMI. Statistical analysis will be conducted using Stata version 11.

  Up to 3 months

• CCAT ability to estimate carotenoid intake

  CCAT carotenoid intake will be correlated with blood carotenoid profiles. Statistical analysis will be conducted using Stata version 11.

  Up to 3 months

Study Arms (1)

Observational (Willett FFQ, Fred Hutchinson FFQ, CCAT)

After consenting to participate in this study, participants will visit the Clinical Research Center (CRC) on 3 occasions. One of the three FFQ's will be completed at each visit and there will be 4 to 6 weeks between visits. Participants will also complete a blood draw and assessment of skin carotenoids at this CRC visit. Prior to each visit, participants will complete a 3-day diet record, a daily sun exposure diary, and a 3-day activity record.

Other: Questionnaire Administration; Other: Laboratory Biomarker Analysis; Device: Spectroscopy

Interventions

Questionnaire Administration OTHER

Complete the Willett FFQ, the Fred Hutchinson FFQ, and the CCAT

Observational (Willett FFQ, Fred Hutchinson FFQ, CCAT)

Laboratory Biomarker Analysis OTHER

Correlative studies

Observational (Willett FFQ, Fred Hutchinson FFQ, CCAT)

Spectroscopy DEVICE

Undergo resonance Raman spectroscopy

Observational (Willett FFQ, Fred Hutchinson FFQ, CCAT)

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from the Ohio State University Campus, Wexner Medical Center Hospitals, and surrounding greater Columbus area.

You may qualify if:

• Be literate and able to understand English
• Have a body mass index (BMI) between 18.5 and 30 kg/m\^2; this represents the lowest end of the healthy BMI range and the upper limit of the overweight BMI range for our target age range
• Be a non-smoker (defined as adults who have never smoked or who have not had a cigarette in the past ten years)
• Not currently be taking any vitamins, minerals, or dietary supplements (or agree to discontinue use for the duration of the study) and agree to consume a standardized daily multivitamin for the remainder of the study (CVS One Daily)
• Voluntarily agree to participate and sign an informed consent document
• Agree to three separate blood draws
• Agree to three separate spectroscopy scans to assess skin carotenoid levels
• Agree to complete three separate 3-day diet records, three separate 3-day activity records, and one habitual physical activity questionnaire

You may not qualify if:

• Have an active metabolic or digestive illness, including malabsorptive disorders, renal insufficiency, hepatic insufficiency, hyper- or hypothyroidism, cachexia, morbid obesity, or short bowel syndrome
• Have an active or a recent history of any condition that causes altered immunity, such as chronic inflammatory disease, autoimmune disorders, cancer, anemia, and blood dyscrasias
• Are heavy alcohol consumers (defined as an average consumption of greater than 2 drinks/day)

Sponsors & Collaborators

• Ohio State University Comprehensive Cancer Center: lead

Study Sites (1)

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center

Columbus, Ohio, 43210, United States

Location

MeSH Terms

Interventions

Spectrum Analysis

Intervention Hierarchy (Ancestors)

Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Steven Clinton, MD, PhD

  Ohio State University Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 18, 2015
• First Posted: November 20, 2015
• Study Start: January 1, 2015
• Primary Completion: July 1, 2015
• Study Completion (Estimated): August 1, 2026
• Last Updated: November 5, 2025

Record last verified: 2025-11

Locations

US (1)