MR Urography vs CT Urography

NCT02606513 | Completed DMC

• 1 other identifier: MR_CT_URO
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Tumors of the UUT are rare and usually presenting as micro- or macrohematuria either symptomatic or asymptomatic. Rapid advances in CT technology accelerated the research into the application of this new technology in the evaluation of the UUT and readily proved to be superior to other imaging modalities. Nevertheless the increase in radiation dose is a major issue of concern. Initial research into the utility of MRI in the evaluation of the UUT was promising, yet the success of CT together with the cost, limited availability and the longer duration of MR urography (MRU) examination, nearly halted the investigations into the feasibility of MRU which is unfortunate as MRU is a safe alternative to CT.

Conditions

Neoplasms

Keywords

Computed Tomography Urography; Magnetic Resonance Urography

Outcome Measures

Primary Outcomes (1)

• Percentage opacification score of different UUT segments using a comprehensive 3T MRU protocol in comparison with 3-phase CTU protocol.

  The UUT will be devided into 6 regions: Upper calyces, lower calyces, pelvis, and upper, middle and lower ureter, and the percentage opacification of each segment will be scored visually using 6 percentage-categories. Results of the opacification scores will be compared between MRU and CTU.

  through study completion, an average of 1 year

Secondary Outcomes (1)

• Performance of MRU in comparison to CTU

  through study completion, an average of 1 year

Study Arms (1)

Comparison of CTU vs MRU

EXPERIMENTAL

CTU is the primary test of choice for the evaluation of the UUT. The performance of MRU will be compared to that of CTU in the same patient population

Other: MR Urography; CT Urography

Interventions

MR Urography; CT Urography OTHER

Comparison of CTU vs MRU

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients scheduled for CTU to rule out malignancy

You may not qualify if:

• GFR \>45; BEnign conditions; Contrast allergy; Contraindications to MRI

Sponsors & Collaborators

• Kuopio University Hospital: lead

Study Sites (1)

Kuopio University Hospital, Department of Clinical Radiology

Kuopio, 70029, Finland

Location

Related Publications (1)

• Sudah M, Masarwah A, Kainulainen S, Pitkanen M, Matikka H, Dabravolskaite V, Aaltomaa S, Vanninen R. Comprehensive MR Urography Protocol: Equally Good Diagnostic Performance and Enhanced Visibility of the Upper Urinary Tract Compared to Triple-Phase CT Urography. PLoS One. 2016 Jul 6;11(7):e0158673. doi: 10.1371/journal.pone.0158673. eCollection 2016.

  PMID: 27384417 DERIVED

MeSH Terms

Conditions

Neoplasms

Study Officials

• Ritva Vanninen, MD; PhD

  Kuopio University Hospital; University of Eastern Finland

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Radiology Consultant

Study Record Dates

• First Submitted: November 12, 2015
• First Posted: November 17, 2015
• Study Start: January 1, 2014
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: March 15, 2016

Record last verified: 2016-03

Locations

FI (1)