NCT02596724

Brief Summary

Prospective observational registry that links results of the genomic and other molecular testing to treatment response and survival measures in patients who have been diagnosed with breast cancer and who are targeted for neo-adjuvant therapy. Analysis includes how tests impact treatment decisions and outcomes.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2015

Longer than P75 for all trials

Geographic Reach
1 country

4 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2015

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

November 2, 2015

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 4, 2015

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2018

Completed
4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2022

Completed
Last Updated

November 5, 2015

Status Verified

November 1, 2015

Enrollment Period

3 years

First QC Date

November 2, 2015

Last Update Submit

November 4, 2015

Conditions

Keywords

Breast CancerNeoadjuvant therapy for breast cancer

Outcome Measures

Primary Outcomes (1)

  • Pathologic response and/or endocrine sensitivity

    Post surgical treatment--usually within 4 months

Secondary Outcomes (1)

  • Metastasis-free/relapse-free survival in molecular subgroups

    5 years

Interventions

Genomic and/or molecular testing of blood or tissue

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with histologically proven invasive breast cancer who have started or are scheduled to start neo-adjuvant chemotherapy or endocrine therapy. Aged 18-90.

You may qualify if:

  • Patients with histologically proven invasive breast cancer who have started or are scheduled to start neo-adjuvant chemotherapy or endocrine therapy
  • Ages 18-90
  • Written informed consent

You may not qualify if:

  • Patients who have had excisional biopsy or axillary dissection
  • Patients with confirmed metastatic disease
  • Patients who have had recent chemotherapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Valley Medical Oncology Consultants

Los Gatos, California, 95032, United States

Location

Coordinated Health Breast Care Specialists

Allentown, Pennsylvania, 18104, United States

Location

Nashville Breast Center

Nashville, Tennessee, 37203, United States

Location

Dallas Surgical Group

Dallas, Texas, 75231, United States

Location

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Histocompatibility Testing

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Immunologic TestsClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisInvestigative TechniquesImmunologic Techniques

Study Officials

  • Pat Whitworth, M.D.

    Nashville Breast Center

    PRINCIPAL INVESTIGATOR
  • Peter Beitsch, M.D.

    Dallas Surgical Group

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
5 Years
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 2, 2015

First Posted

November 4, 2015

Study Start

July 1, 2015

Primary Completion

July 1, 2018

Study Completion

July 1, 2022

Last Updated

November 5, 2015

Record last verified: 2015-11

Locations