NCT02596542

Brief Summary

Cold-water immersion (CWI) is a frequently applied strategy to accelerate post-exercise recovery in both recreational as well as professional athletes. However, the effect of repeated post-exercise CWI on other recovery strategies remains unclear.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2015

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2015

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

November 3, 2015

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 4, 2015

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2016

Completed
Last Updated

August 2, 2016

Status Verified

August 1, 2016

Enrollment Period

6 months

First QC Date

November 3, 2015

Last Update Submit

August 1, 2016

Conditions

Post-exercise Cold Water Immersion

Outcome Measures

Primary Outcomes (1)

  • Muscle protein synthesis (expressed as fractional synthetic rate (FSR in %/h)

    2 weeks

Secondary Outcomes (2)

  • Muscle temperature (expressed as degrees celsius)

    1 day

  • Glycogen concentration (expressed as micromol glycosol units*g dry wt)

    1 day

Study Arms (1)

Water temperature

EXPERIMENTAL
Other: Water immersion

Interventions

Water immersionOTHER

Different temperatures of cold water immersion will be assessed

Water temperature

Eligibility Criteria

Age18 Years - 35 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Males
  • Aged between 18-35 years
  • Healthy, recreationally active
  • BMI \< 25 kg/m2
  • The ability to comply with the protocol (i.e. the set-up for the CWI is designed for subjects that are at least 1.70 m or taller).

You may not qualify if:

  • Smoking
  • Allergies to milk proteins (whey or casein)
  • Female
  • Arthritic conditions
  • A history of neuromuscular problems
  • Recent (\<1 y) participation in amino acid tracer studies
  • Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
  • Individuals with GI diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Maastricht University

Maastricht, Limburg, 6200 MD, Netherlands

Location

Related Publications (1)

  • Gorissen SHM, Trommelen J, Kouw IWK, Holwerda AM, Pennings B, Groen BBL, Wall BT, Churchward-Venne TA, Horstman AMH, Koopman R, Burd NA, Fuchs CJ, Dirks ML, Res PT, Senden JMG, Steijns JMJM, de Groot LCPGM, Verdijk LB, van Loon LJC. Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. J Nutr. 2020 Aug 1;150(8):2041-2050. doi: 10.1093/jn/nxaa024.

    PMID: 32069356DERIVED

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

November 3, 2015

First Posted

November 4, 2015

Study Start

November 1, 2015

Primary Completion

May 1, 2016

Study Completion

May 1, 2016

Last Updated

August 2, 2016

Record last verified: 2016-08

Locations

NL(1)